{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T21:41:43Z","timestamp":1776634903875,"version":"3.51.2"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE023538"],"award-info":[{"award-number":["R01DE023538"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H05060"],"award-info":[{"award-number":["15H05060"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171912","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T19:19:58Z","timestamp":1487704798000},"page":"e0171912","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Morphological study of tooth development in podoplanin-deficient mice"],"prefix":"10.1371","volume":"12","author":[{"given":"Kenyo","family":"Takara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruhiko","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinari","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junro","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0167-4838(98)00231-3","article-title":"Purification and analysis of RT140, a type I alveolar epithelial cell apical membrane protein","volume":"1429","author":"RF Gonzalez","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"ref2","first-page":"1141","article-title":"Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regu- lated in puromycin nephrosis","volume":"151","author":"S Breiteneder-Geleff","year":"1997","journal-title":"Am J Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1242\/jcs.112.24.4601","article-title":"Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes","volume":"112","author":"FG Scholl","year":"1999","journal-title":"J Cell Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"51599","DOI":"10.1074\/jbc.M309935200","article-title":"Molecular identification of Aggrus\/T1\u03b1 as a platelet aggregation-inducing factor expressed in colorectal tumors","volume":"278","author":"Y Kato","year":"2003","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"38838","DOI":"10.1074\/jbc.M407210200","article-title":"Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha\/Podoplanin) molecules expressed in Chinese hamster ovary cells","volume":"279","author":"M Kaneko","year":"2004","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1349-7006.2007.00634.x","article-title":"Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2","volume":"99","author":"Y Kato","year":"2008","journal-title":"Cancer Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/40.5.1374092","article-title":"Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus","volume":"40","author":"A Farr","year":"1992","journal-title":"J Histochem Cytochem"},{"issue":"Pt 2","key":"ref8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/bj3410277","article-title":"Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium","volume":"341","author":"G Zimmer","year":"1999","journal-title":"Biochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdg342","article-title":"T1a\/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema","volume":"22","author":"V Schacht","year":"2003","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00018-007-7040-z","article-title":"Molecular mechanisms of lymphatic vascular development","volume":"64","author":"T M\u00e4kinen","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2009-04-216069","article-title":"Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation","volume":"115","author":"P Uhrin","year":"2010","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1242\/jcs.03218","article-title":"Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition","volume":"119","author":"E Mart\u00edn-Villar","year":"2006","journal-title":"J Cell Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature13814","article-title":"Dendritic cells control fibroblastic reticular network tension and lymph node expansion","volume":"514","author":"SE Acton","year":"2014","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/8756-3282(95)00457-2","article-title":"Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes","volume":"18","author":"A Wetterwald","year":"1996","journal-title":"Bone"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s004180050334","article-title":"Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17\/ 2.8","volume":"111","author":"E Schulze","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0065-1281(99)80043-9","article-title":"Immunohistochemical localization of the differentiation marker E11 in dental development of rats","volume":"101","author":"W Schwab","year":"1999","journal-title":"Acta Histochem"},{"key":"ref17","first-page":"511","article-title":"Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells","volume":"1","author":"K Nose","year":"1990","journal-title":"Cell Growth Differ"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/MCB.02120-05","article-title":"E11\/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation","volume":"26","author":"K Zhang","year":"2006","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0167-4889(88)90173-5","article-title":"Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells","volume":"970","author":"LG Dobbs","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/dbio.1995.1024","article-title":"Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives","volume":"167","author":"AK Rishi","year":"1995","journal-title":"Dev Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0012-1606(02)00098-2","article-title":"T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolous formation at birth","volume":"256","author":"MI Ramirez","year":"2003","journal-title":"Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1165\/ajrcmb.14.6.8652186","article-title":"T1alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus and ciliary epithelia of adult rats","volume":"14","author":"MC Williams","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1469-7580.2012.01484.x","article-title":"The expression of podoplanin and classic cadherins in the mouse brain","volume":"220","author":"C Kaji","year":"2012","journal-title":"J Anat"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/modpathol.3800259","article-title":"Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma","volume":"18","author":"AY Chu","year":"2005","journal-title":"Mod Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1440-1827.2005.01791.x","article-title":"Podoplanin as a marker for mesothelioma","volume":"55","author":"N Kimura","year":"2005","journal-title":"Pathol Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.archoralbio.2008.02.006","article-title":"Expression of podoplanin in the mouse salivary glands","volume":"53","author":"M Hata","year":"2008","journal-title":"Arch Oral Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1267\/ahc.08019","article-title":"Expression of podoplanin in the mouse tooth germ and apical bud cells","volume":"41","author":"Y Sawa","year":"2008","journal-title":"Acta Histochem Cytochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1267\/ahc.10011","article-title":"Immunoelectron microscopic study of podoplanin localization in mouse salivary gland myoepithelium","volume":"43","author":"M Hata","year":"2010","journal-title":"Acta Histochem Cytochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1267\/ahc.10023","article-title":"Immunohistochemical examination for the distribution of podoplanin-expressing cells in developing mouse molar tooth germs","volume":"43","author":"Y Imaizumi","year":"2010","journal-title":"Acta Histochem Cytochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1267\/ahc.11037","article-title":"Expression of podoplanin and classical cadherins in salivary gland epithelial cells of klotho-deficient mice","volume":"44","author":"I Amano","year":"2011","journal-title":"Acta Histochem Cytochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9440(10)62311-5","article-title":"Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors","volume":"166","author":"V Schacht","year":"2005","journal-title":"Am J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00428-006-0223-4","article-title":"Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours","volume":"449","author":"SB Sonne","year":"2006","journal-title":"Virchows Arch"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1309\/7P8U659JBJCV6EEU","article-title":"Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors","volume":"128","author":"H Yu","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/PAI.0b013e318183a8e2","article-title":"Podoplanin (D2-40) is a highly effective marker of follicular dendritic cells","volume":"17","author":"DK Marsee","year":"2009","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1267\/ahc.10008","article-title":"Immunohistochemical examination of the distribution of cells expressed lymphatic endothelial marker podoplanin and LYVE-1 in the mouse tongue tissue","volume":"43","author":"Y Noda","year":"2010","journal-title":"Acta Histochem Cytochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1267\/ahc.13035","article-title":"Distribution of podoplanin-expressing cells in the mouse nervous systems","volume":"46","author":"M Tomooka","year":"2013","journal-title":"Acta Histochem Cytochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00401-006-0063-y","article-title":"Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression","volume":"111","author":"K Mishima","year":"2006","journal-title":"Acta Neuropathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00428-005-0133-x","article-title":"Podoplanin is expressed in subsets of tumors of the central nervous system","volume":"448","author":"J Shibahara","year":"2006","journal-title":"Virchows Arch"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1309\/M7D5KTVYYE51XYQA","article-title":"Diagnostic implications of podoplanin expression in peripheral nerve sheath neoplasms","volume":"129","author":"CH Jokinen","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"ref40","first-page":"373","article-title":"Podoplanin is a potential marker for the diagnosis of ependymoma: a comparative study with epithelial membrane antigen (EMA)","volume":"28","author":"K Ishizawa","year":"2009","journal-title":"Clin Neuropathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ydbio.2006.11.025","article-title":"The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development","volume":"303","author":"K Oka","year":"2007","journal-title":"Dev Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fendo.2015.00105","article-title":"Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study","volume":"6","author":"JL Coleman","year":"2015","journal-title":"Front Endocrinol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1679\/aohc.66.123","article-title":"Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects and plants","volume":"66","author":"T Kawamoto","year":"2003","journal-title":"Arch Histol Cytol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"27","author":"Y Chai","year":"2000","journal-title":"Development"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/stem.2","article-title":"Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development","volume":"27","author":"IH Chung","year":"2009","journal-title":"Stem Cells"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1634\/stemcells.2006-0360","article-title":"Potential of dental mesenchymal cells in developing teeth","volume":"25","author":"H Yamazaki","year":"2007","journal-title":"Stem Cells"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T16:11:23Z","timestamp":1719072683000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171912"}},"subtitle":[],"editor":[{"given":"Jung-Eun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171912","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}