{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:30:56Z","timestamp":1790242256474,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Province Natural Science Foundation","award":["no. LY15H090012"],"award-info":[{"award-number":["no. LY15H090012"]}]},{"name":"General Administration of Sport of China","award":["no. 2014B101"],"award-info":[{"award-number":["no. 2014B101"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0171976","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T14:59:10Z","timestamp":1487084350000},"page":"e0171976","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Moderate injury in motor-sensory cortex causes behavioral deficits accompanied by electrophysiological changes in mice adulthood"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-491X","authenticated-orcid":true,"given":"Wei","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0883073814544363","article-title":"The Epidemiology of Traumatic Brain Injury in Children and Youths: A Review of Research Since 1990","volume":"31","author":"DJ Thurman","year":"2016","journal-title":"Journal of child neurology"},{"key":"ref2","article-title":"Epidemiology of Global Pediatric Traumatic Brain Injury: Qualitative Review","author":"MC Dewan","year":"2016","journal-title":"World neurosurgery"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1080\/02699050903283239","article-title":"Cognitive outcome in children and young adults who sustained severe and moderate traumatic brain injury 10 years earlier","volume":"23","author":"G Horneman","year":"2009","journal-title":"Brain Inj"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.acn.2007.03.004","article-title":"Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study","volume":"22","author":"JR Wozniak","year":"2007","journal-title":"Archives of clinical neuropsychology: the official journal of the National Academy of Neuropsychologists"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.nicl.2015.02.002","article-title":"White matter disruption in moderate\/severe pediatric traumatic brain injury: advanced tract-based analyses","volume":"7","author":"EL Dennis","year":"2015","journal-title":"Neuroimage Clin"},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1089\/neu.2013.2934","article-title":"Working memory and corpus callosum microstructural integrity after pediatric traumatic brain injury: a diffusion tensor tractography study","volume":"30","author":"A Treble","year":"2013","journal-title":"Journal of neurotrauma"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1152\/jn.00970.2014","article-title":"Repetitive mild traumatic brain injury induces ventriculomegaly and cortical thinning in juvenile rats","volume":"113","author":"C Goddeyne","year":"2015","journal-title":"Journal of neurophysiology"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1089\/neu.2011.1883","article-title":"Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthood","volume":"29","author":"DO Ajao","year":"2012","journal-title":"Journal of neurotrauma"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2005.01.052","article-title":"Regional hippocampal alteration associated with cognitive deficit following experimental brain injury: a systems, network and cellular evaluation","volume":"133","author":"BM Witgen","year":"2005","journal-title":"Neuroscience"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"e24566","DOI":"10.1371\/journal.pone.0024566","article-title":"Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus","volume":"6","author":"X Gao","year":"2011","journal-title":"PloS one"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1523\/JNEUROSCI.12-12-04846.1992","article-title":"Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus","volume":"12","author":"DH Lowenstein","year":"1992","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.brainres.2014.07.036","article-title":"Decreased bursting and novel object-specific cell firing in the hippocampus after mild traumatic brain injury","volume":"1582","author":"C Munyon","year":"2014","journal-title":"Brain research"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hipo.450030307","article-title":"Phase relationship between hippocampal place units and the EEG theta rhythm","volume":"3","author":"J O'Keefe","year":"1993","journal-title":"Hippocampus"},{"issue":"2","key":"ref14","first-page":"461","article-title":"Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral correlates and firing repertoires","volume":"41","author":"JB Ranck Jr","year":"1973","journal-title":"Experimental neurology"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"011010","DOI":"10.1115\/1.4000164","article-title":"Age-dependent regional mechanical properties of the rat hippocampus and cortex","volume":"132","author":"BS Elkin","year":"2010","journal-title":"J Biomech Eng"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.bjp.0707273","article-title":"The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats","volume":"151","author":"L Robinson","year":"2007","journal-title":"British journal of pharmacology"},{"key":"ref17","article-title":"Enhancement of Working Memory and Task-Related Oscillatory Activity Following Intermittent Theta Burst Stimulation in Healthy Controls","author":"KE Hoy","year":"2015","journal-title":"Cerebral cortex"},{"issue":"Pt 7","key":"ref18","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/brain\/awv095","article-title":"Visual-spatial memory may be enhanced with theta burst deep brain stimulation of the fornix: a preliminary investigation with four cases","volume":"138","author":"JP Miller","year":"2015","journal-title":"Brain: a journal of neurology"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1089\/neu.2011.2192","article-title":"Mild traumatic brain injury is associated with impaired hippocampal spatiotemporal representation in the absence of histological changes","volume":"29","author":"K Eakin","year":"2012","journal-title":"Journal of neurotrauma"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11920-016-0719-9","article-title":"The Impact of Traumatic Brain Injury on the Aging Brain","volume":"18","author":"JS Young","year":"2016","journal-title":"Current psychiatry reports"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1037\/bne0000046","article-title":"Traumatic brain injury in late adolescent rats: effects on adulthood memory and anxiety","volume":"129","author":"L Amoros-Aguilar","year":"2015","journal-title":"Behavioral neuroscience"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1089\/neu.2014.3502","article-title":"Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis, and neuroprotection after traumatic brain injury in rats","volume":"32","author":"A Jacotte-Simancas","year":"2015","journal-title":"Journal of neurotrauma"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1089\/neu.2007.0452","article-title":"Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions","volume":"25","author":"J Tsenter","year":"2008","journal-title":"Journal of neurotrauma"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/nprot.2010.112","article-title":"Fluid-percussion-induced traumatic brain injury model in rats","volume":"5","author":"SV Kabadi","year":"2010","journal-title":"Nature protocols"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/neu.2006.23.97","article-title":"Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats","volume":"23","author":"KD Statler","year":"2006","journal-title":"Journal of neurotrauma"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2003.09.010","article-title":"Effects of stress and etifoxine on pentobarbital-induced loss of righting reflex in Balb\/cByJ and C57BL\/6J mice","volume":"353","author":"M Verleye","year":"2003","journal-title":"Neuroscience letters"},{"key":"ref27","article-title":"The Mouse Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"2007"},{"issue":"49","key":"ref28","doi-asserted-by":"crossref","DOI":"10.3791\/2376","article-title":"Assessment of motor balance and coordination in mice using the balance beam","author":"TN Luong","year":"2011","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nn.3626","article-title":"Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality","volume":"17","author":"TN Huang","year":"2014","journal-title":"Nature neuroscience"},{"issue":"6890","key":"ref30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nature00807","article-title":"Role of experience and oscillations in transforming a rate code into a temporal code","volume":"417","author":"MR Mehta","year":"2002","journal-title":"Nature"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1523\/JNEUROSCI.10-04-01110.1990","article-title":"Spatial firing properties of hippocampal theta cells","volume":"10","author":"JL Kubie","year":"1990","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1152\/jn.1985.53.4.926","article-title":"Bursts and recurrences of bursts in the spike trains of spontaneously active striate cortex neurons","volume":"53","author":"CR Legendy","year":"1985","journal-title":"Journal of neurophysiology"},{"key":"ref33","article-title":"Mouse behavioral testing: how to Use Mice in Behavioral Neuroscience","author":"D W","year":"2011"},{"issue":"40","key":"ref34","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1073\/pnas.0406344101","article-title":"Spatial memory, recognition memory, and the hippocampus","volume":"101","author":"NJ Broadbent","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Pt 1","key":"ref35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/brain\/awp264","article-title":"Stereology of cerebral cortex after traumatic brain injury matched to the Glasgow outcome score","volume":"133","author":"WL Maxwell","year":"2010","journal-title":"Brain: a journal of neurology"},{"key":"ref36","article-title":"The Mouse Nervous System: Chapter 4-Neocortex","author":"MTK Kirkcaldie","year":"2011"},{"issue":"6008","key":"ref37","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1126\/science.1195797","article-title":"Motor control by sensory cortex","volume":"330","author":"F Matyas","year":"2010","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12974-015-0386-5","article-title":"Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury","volume":"12","author":"HY Febinger","year":"2015","journal-title":"Journal of neuroinflammation"},{"issue":"4562","key":"ref39","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1126\/science.7100929","article-title":"Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury","volume":"217","author":"DM Feeney","year":"1982","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbr.2014.09.050","article-title":"Neural circuitry for rat recognition memory","volume":"285","author":"EC Warburton","year":"2015","journal-title":"Behavioural brain research"},{"issue":"39","key":"ref41","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1523\/JNEUROSCI.2278-15.2015","article-title":"Bidirectional Modulation of Recognition Memory","volume":"35","author":"JW Ho","year":"2015","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1523\/JNEUROSCI.17-05-01880.1997","article-title":"Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay","volume":"17","author":"SB Floresco","year":"1997","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"29","key":"ref43","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","article-title":"When is the hippocampus involved in recognition memory?","volume":"31","author":"GR Barker","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0028-3932(94)90067-1","article-title":"Impairment of memory following discrete thalamic infarction","volume":"32","author":"AJ Parkin","year":"1994","journal-title":"Neuropsychologia"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1111\/j.1460-9568.1997.tb01659.x","article-title":"The recognition memory deficit caused by mediodorsal thalamic lesion in non-human primates: a comparison with rhinal cortex lesion","volume":"9","author":"A Parker","year":"1997","journal-title":"The European journal of neuroscience"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nn.3788","article-title":"Hippocampal-neocortical functional reorganization underlies children&apos;s cognitive development","volume":"17","author":"S Qin","year":"2014","journal-title":"Nature neuroscience"},{"issue":"42","key":"ref47","doi-asserted-by":"crossref","first-page":"14123","DOI":"10.1523\/JNEUROSCI.0801-15.2015","article-title":"Hippocampal Volume Reduction in Humans Predicts Impaired Allocentric Spatial Memory in Virtual-Reality Navigation","volume":"35","author":"S Guderian","year":"2015","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnagi.2013.00041","article-title":"History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life","volume":"5","author":"JM Monti","year":"2013","journal-title":"Frontiers in aging neuroscience"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fnhum.2013.00395","article-title":"Traumatic brain injury, neuroimaging, and neurodegeneration","volume":"7","author":"ED Bigler","year":"2013","journal-title":"Frontiers in human neuroscience"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cortex.2012.02.011","article-title":"Long-term declarative memory deficits in diffuse TBI: correlations with cortical thickness, white matter integrity and hippocampal volume","volume":"49","author":"EM Palacios","year":"2013","journal-title":"Cortex; a journal devoted to the study of the nervous system and behavior"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3171\/jns.1990.73.6.0889","article-title":"Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury","volume":"73","author":"Y Katayama","year":"1990","journal-title":"Journal of neurosurgery"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/jcbfm.1992.3","article-title":"Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury","volume":"12","author":"T Kawamata","year":"1992","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/08977150150502587","article-title":"Age-dependency of 45calcium accumulation following lateral fluid percussion: acute and delayed patterns","volume":"18","author":"CL Osteen","year":"2001","journal-title":"Journal of neurotrauma"},{"issue":"7","key":"ref54","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1111\/j.1460-9568.2008.06156.x","article-title":"Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal neurons surviving brain injury","volume":"27","author":"DA Sun","year":"2008","journal-title":"The European journal of neuroscience"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neulet.2008.05.113","article-title":"Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury","volume":"441","author":"LS Deshpande","year":"2008","journal-title":"Neuroscience letters"},{"issue":"7","key":"ref56","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/ph6070788","article-title":"Voltage-gated calcium channel antagonists and traumatic brain injury","volume":"6","author":"G Gurkoff","year":"2013","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1089\/neu.2010.1370","article-title":"Hippocampal theta dysfunction after lateral fluid percussion injury","volume":"27","author":"M Fedor","year":"2010","journal-title":"Journal of neurotrauma"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.biosystems.2015.08.004","article-title":"Phase-locking of bursting neuronal firing to dominant LFP frequency components","volume":"136","author":"M Constantinou","year":"2015","journal-title":"Bio Systems"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/hipo.22338","article-title":"Improved learning and memory with theta-burst stimulation of the fornix in rat model of traumatic brain injury","volume":"24","author":"JA Sweet","year":"2014","journal-title":"Hippocampus"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/neu.2012.2646","article-title":"Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury","volume":"30","author":"DJ Lee","year":"2013","journal-title":"Journal of neurotrauma"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(86)90579-2","article-title":"Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation","volume":"368","author":"J Larson","year":"1986","journal-title":"Brain research"},{"issue":"18","key":"ref62","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1523\/JNEUROSCI.18-18-07118.1998","article-title":"Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation","volume":"18","author":"MJ Thomas","year":"1998","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0171976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T13:44:28Z","timestamp":1568814268000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0171976"}},"subtitle":[],"editor":[{"given":"Michelle M.","family":"Adams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0171976","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}