{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:48:09Z","timestamp":1773280089037,"version":"3.50.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571431"],"award-info":[{"award-number":["81571431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY15H040010"],"award-info":[{"award-number":["LY15H040010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172191","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T01:16:28Z","timestamp":1488330988000},"page":"e0172191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The platelet-derived growth factor receptor\/STAT3 signaling pathway regulates the phenotypic transition of corpus cavernosum smooth muscle in rats"],"prefix":"10.1371","volume":"12","author":[{"given":"Jun-Feng","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Feng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao-Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Dong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.ijir.3900328","article-title":"Is there a role of hypoxemia in penile fibrosis: a view point presented to the Society for the Study of Impotence","volume":"10","author":"RB Moreland","year":"1998","journal-title":"Int J Impot Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0022-5347(01)65578-2","article-title":"Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure","volume":"156","author":"A Nehra","year":"1996","journal-title":"J Urol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/j.1464-410X.2008.08251.x","article-title":"Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction","volume":"103","author":"I Kovanecz","year":"2009","journal-title":"BJU Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"GK Owens","year":"2004","journal-title":"Physiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/ATVBAHA.108.178749","article-title":"Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype","volume":"29","author":"AW Orr","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref6","first-page":"47","article-title":"Molecular syudies of human corporal smooth muscle:Implications for the understanding, diagnosis, and treatment of erectile dysfunction","volume":"1","author":"GJ Christ","year":"1997","journal-title":"Mol Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ijir.2012.16","article-title":"Characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction","volume":"24","author":"AY Wei","year":"2012","journal-title":"Int J Impot Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00441-014-1902-0","article-title":"Phenotypic transition of corpus cavernosum smooth muscle cells subjected to hypoxia","volume":"357","author":"BD Lv","year":"2014","journal-title":"Cell Tissue Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e105186","DOI":"10.1371\/journal.pone.0105186","article-title":"Phenotypic modulation of corpus cavernosum smooth cells in a rat model of cavernous neurectomy","volume":"9","author":"F Yang","year":"2014","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"27406","DOI":"10.1074\/jbc.M101056200","article-title":"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor","volume":"276","author":"DG Gilbertson","year":"2001","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/35074593","article-title":"PDGF-D, a new protease-activated growth factor","volume":"3","author":"WJ LaRochelle","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/abbi.2001.2707","article-title":"New members of the platelet-derived growth factor family of mitogens","volume":"398","author":"CH Heldin","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1742-7843.2008.00231.x","article-title":"Caffeine inhibits the proliferation of liver cancer cells and activates the MEK\/ERK\/EGFR signalling pathway","volume":"102","author":"J Okano","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"37815","DOI":"10.1074\/jbc.M707461200","article-title":"Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology","volume":"282","author":"S Nakata","year":"2007","journal-title":"J Biol Chem"},{"key":"ref15","first-page":"279","article-title":"A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells","volume":"45","author":"AM Doanes","year":"1998","journal-title":"Biochem Mol Biol Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0021-9150(01)00662-1","article-title":"Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits","volume":"161","author":"K Inoue","year":"2002","journal-title":"Atherosclerosis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1465-9921-11-145","article-title":"DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1","volume":"11","author":"P Seidel","year":"2010","journal-title":"Respir Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BJ20121344","article-title":"PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress","volume":"451","author":"JK Salabei","year":"2013","journal-title":"Biochem J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/j.1939-4640.1996.tb01757.x","article-title":"Ultrastructural and immunohistochemical characterization of the tunica albuginea in Peyronie&apos;s disease and veno-occlusive dysfunction","volume":"17","author":"V Gentile","year":"1996","journal-title":"J Androl"},{"key":"ref20","first-page":"593","article-title":"Platelet-derived growth factor-BB induces phenotypic transformation of corpus cavernosum smooth muscle cells in SD rats","volume":"21","author":"JT Luo","year":"2015","journal-title":"Zhonghua Nan Ke Xue"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.eururo.2005.01.008","article-title":"Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering","volume":"47","author":"A Plaits","year":"2005","journal-title":"Eur Urol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1743-6109.2008.01105.x","article-title":"Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat","volume":"6","author":"MG Ferrini","year":"2009","journal-title":"J Sex Med"},{"key":"ref23","first-page":"54","article-title":"Isolation of human adult stem cells from muscle biopsy for future treatment of urinary incontinence","volume":"8","author":"F Sharifiaghdas","year":"2011","journal-title":"Urol J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e35435","DOI":"10.1371\/journal.pone.0035435","article-title":"MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells","volume":"7","author":"F Tang","year":"2012","journal-title":"PLoS One"},{"key":"ref25","first-page":"32","article-title":"Inhibition of glucocorticoid-induced alteration of vimentin by a glucocorticoid receptor antagonist RU486 in the organ-cultured rat lens","volume":"17","author":"GL Xie","year":"2011","journal-title":"Mol Vis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e70528","DOI":"10.1371\/journal.pone.0070528","article-title":"Pirfenidone nanoparticles improve corneal wound healing and prevent scarring following alkali burn","volume":"8","author":"S Chowdhury","year":"2013","journal-title":"PLoS One"},{"key":"ref27","first-page":"44","article-title":"Changes of large molecular weight hyaluronan and versican in the mouse pubic symphysis through pregnancy","volume":"86","author":"RG Rosa","year":"2012","journal-title":"Biol Reprod"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1465-9921-7-117","article-title":"Endogenous laminin is required for human airway smooth muscle cell maturation","volume":"7","author":"T Tran","year":"2006","journal-title":"Respir Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/path.1945","article-title":"PDGFRalpha, PDGFRbeta and KIT expression\/activation in conventional chondrosarcoma","volume":"208","author":"MS Lagonigro","year":"2006","journal-title":"J Pathol"},{"key":"ref30","first-page":"559","article-title":"Phenotypic and cytogenetic characterization of a human corpus cavernosum cell line (DS-1)","volume":"30","author":"R Dahiya","year":"1993","journal-title":"Biochem Mol Biol Int"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/01.ju.0000048974.47461.50","article-title":"Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction","volume":"169","author":"HM User","year":"2003","journal-title":"J Urol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1464-410X.2011.10162.x","article-title":"Cavernous smooth muscle hyperplasia in a rat model of hyperlipidaemia-associated erectile dysfunction","volume":"108","author":"X Qiu","year":"2011","journal-title":"BJU Int"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/01.ATV.16.6.815","article-title":"Phenotypic heterogeneity of rat arterial smooth muscle cell clones. Implications for the development of experimental intimal thickening","volume":"16","author":"ML Bochaton-Piallat","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0021-9150(87)90109-2","article-title":"A review of the proliferative behaviour, morphology and phenotypes of vascular smooth muscle","volume":"63","author":"RJ Dilley","year":"1987","journal-title":"Atherosclerosis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1016\/j.bpj.2008.11.074","article-title":"Cell-shape regulation of smooth muscle cell proliferation","volume":"96","author":"RG Thakar","year":"2009","journal-title":"Biophys J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1979.59.1.1","article-title":"The smooth muscle cell in culture","volume":"59","author":"J Chamley-Campbell","year":"1979","journal-title":"Physiol Rev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1432-0436.1987.tb01563.x","article-title":"Plasma fibronectin promotes modulation of arterial smooth-muscle cells from contractile to synthetic phenotype","volume":"33","author":"U Hedin","year":"1987","journal-title":"Differentiation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"GK Owens","year":"2004","journal-title":"Physiol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2741\/1803","article-title":"Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase","volume":"11","author":"TM Lincoln","year":"2006","journal-title":"Front Biosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"P Carmeliet","year":"2011","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"H2042","DOI":"10.1152\/ajpheart.00625.2003","article-title":"Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes","volume":"286","author":"F Dandre","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.4161\/cbt.6.12.4976","article-title":"PDGF BB induces VEGF secretion in ovarian cancer","volume":"6","author":"D Matei","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.devcel.2011.04.019","article-title":"PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development","volume":"20","author":"LE Olson","year":"2011","journal-title":"Dev Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1677\/joe.0.1700395","article-title":"Platelet-derived growth factor (PDGF) and PDGF receptors in rat corpus cavernosum: changes in expression after transient in vivo hypoxia","volume":"170","author":"A Aversa","year":"2001","journal-title":"J Endocrinol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"C1307","DOI":"10.1152\/ajpcell.00608.2008","article-title":"Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients","volume":"297","author":"HA Madi","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1158\/0008-5472.CAN-10-2350","article-title":"The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers","volume":"71","author":"JF Lo","year":"2011","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/cvr\/cvv103","article-title":"Emerging translational approaches to target STAT3 signalling and its impact on vascular disease","volume":"106","author":"J Dutzmann","year":"2015","journal-title":"Cardiovasc Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"19641","DOI":"10.1074\/jbc.M114.630111","article-title":"STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin","volume":"290","author":"XH Liao","year":"2015","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T19:09:09Z","timestamp":1719083349000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172191"}},"subtitle":[],"editor":[{"given":"Gianfranco","family":"Pintus","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]}}}