{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:17:16Z","timestamp":1794014236047,"version":"4.8.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372816"],"award-info":[{"award-number":["81372816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JUSRP115A31"],"award-info":[{"award-number":["JUSRP115A31"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673033"],"award-info":[{"award-number":["81673033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172324","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T19:37:08Z","timestamp":1487965028000},"page":"e0172324","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["P53 and Ki-67 as prognostic markers in triple-negative breast cancer patients"],"prefix":"10.1371","volume":"12","author":[{"given":"Yunbao","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"issue":"2","key":"ref1","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"LA Torre","year":"2015","journal-title":"CA: a cancer journal for clinicians"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ejca.2011.06.028","article-title":"Management and treatment of triple-negative breast cancer patients from the NEMESI study: an Italian experience","volume":"48","author":"V Adamo","year":"2012","journal-title":"European journal of cancer"},{"key":"ref3","article-title":"Triple-negative breast cancer: is there a treatment on the horizon?","author":"H Yao","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10549-011-1619-7","article-title":"Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse","volume":"132","author":"JC Harrell","year":"2012","journal-title":"Breast cancer research and treatment"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrclinonc.2016.66","article-title":"Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease","volume":"13","author":"G Bianchini","year":"2016","journal-title":"Nature reviews Clinical oncology"},{"issue":"Suppl 1","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1634\/theoncologist.2011-S1-01","article-title":"Triple-negative breast cancer: an unmet medical need","volume":"16","author":"CA Hudis","year":"2011","journal-title":"The oncologist"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.4143\/crt.2015.463","article-title":"Identification of Prognostic Risk Factors for Transient and Persistent Lymphedema after Multimodal Treatment for Breast Cancer","volume":"48","author":"M Kim","year":"2016","journal-title":"Cancer research and treatment: official journal of Korean Cancer Association"},{"issue":"25","key":"ref8","doi-asserted-by":"crossref","first-page":"38864","DOI":"10.18632\/oncotarget.8778","article-title":"Prognosis of subtypes of the mucinous breast carcinoma in Chinese women: a population-based study of 32-year experience (1983\u20132014)","volume":"7","author":"B Pan","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e0163254","DOI":"10.1371\/journal.pone.0163254","article-title":"Clinicopathological Features and Prognostic Factors Affecting Survival Outcomes in Isolated Locoregional Recurrence of Breast Cancer: Single-Institutional Series","volume":"11","author":"MY Lee","year":"2016","journal-title":"PloS one"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.4143\/crt.2015.430","article-title":"Association between Mutation and Expression of TP53 as a Potential Prognostic Marker of Triple-Negative Breast Cancer","volume":"48","author":"JY Kim","year":"2016","journal-title":"Cancer research and treatment: official journal of Korean Cancer Association"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13058-016-0765-6","article-title":"Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups","volume":"18","author":"M Abubakar","year":"2016","journal-title":"Breast cancer research: BCR"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026070","article-title":"p53 in the DNA-Damage-Repair Process","volume":"6","author":"AB Williams","year":"2016","journal-title":"Cold Spring Harbor perspectives in medicine"},{"issue":"6250","key":"ref13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/342705a0","article-title":"Mutations in the p53 gene occur in diverse human tumour types","volume":"342","author":"JM Nigro","year":"1989","journal-title":"Nature"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/ijc.27767","article-title":"Distinct tumor protein p53 mutants in breast cancer subgroups","volume":"132","author":"A Dumay","year":"2013","journal-title":"International journal of cancer"},{"key":"ref15","article-title":"Low Ki67\/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer","author":"X Feng","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2217\/bmm-2015-0064","article-title":"A meta-analysis of biomarkers for the prognosis of triple-negative breast cancer patients","volume":"10","author":"Y Gui","year":"2016","journal-title":"Biomarkers in medicine"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/annonc\/mdt303","article-title":"Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013","volume":"24","author":"A Goldhirsch","year":"2013","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology \/ ESMO"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1200\/JCO.2009.24.9284","article-title":"Breast cancer subtypes and the risk of local and regional relapse","volume":"28","author":"KD Voduc","year":"2010","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"15","key":"ref19","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1200\/JCO.2006.10.3523","article-title":"Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system","volume":"25","author":"CA Hudis","year":"2007","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"15","key":"ref20","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/sj.onc.1210302","article-title":"TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes","volume":"26","author":"A Petitjean","year":"2007","journal-title":"Oncogene"},{"key":"ref21","article-title":"Association Between Mutation and Expression of TP53 as a Potential Prognostic Marker of Triple-Negative Breast Cancer","author":"JY Kim","year":"2016","journal-title":"Cancer research and treatment: official journal of Korean Cancer Association"},{"key":"ref22","article-title":"Coexistent Loss of the Expressions of BRCA1 and p53 Predicts Poor Prognosis in Triple-Negative Breast Cancer","author":"MC Kim","year":"2016","journal-title":"Annals of surgical oncology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jjco\/hyq227","article-title":"p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features","volume":"41","author":"E Biganzoli","year":"2011","journal-title":"Japanese journal of clinical oncology"},{"key":"ref24","article-title":"New insight on the biological role of p53 protein as a tumor suppressor: re-evaluation of its clinical significance in triple-negative breast cancer","author":"MS Jin","year":"2016","journal-title":"Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"e0124658","DOI":"10.1371\/journal.pone.0124658","article-title":"Distinguishing Low-Risk Luminal A Breast Cancer Subtypes with Ki-67 and p53 Is More Predictive of Long-Term Survival","volume":"10","author":"SK Lee","year":"2015","journal-title":"PloS one"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1038\/sj.bjc.6690628","article-title":"Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis","volume":"80","author":"PD Pharoah","year":"1999","journal-title":"British journal of cancer"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/humu.10174","article-title":"TP53 and breast cancer","volume":"21","author":"AL Borresen-Dale","year":"2003","journal-title":"Human mutation"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10549-015-3559-0","article-title":"Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients","volume":"153","author":"F Petrelli","year":"2015","journal-title":"Breast cancer research and treatment"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"e0119565","DOI":"10.1371\/journal.pone.0119565","article-title":"Evaluation of an Optimal Cut-Off Point for the Ki-67 Index as a Prognostic Factor in Primary Breast Cancer: A Retrospective Study","volume":"10","author":"R Tashima","year":"2015","journal-title":"PloS one"},{"issue":"Suppl 1","key":"ref30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1634\/theoncologist.2011-S1-71","article-title":"Directed therapy of subtypes of triple-negative breast cancer","volume":"16","author":"LA Carey","year":"2011","journal-title":"The oncologist"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1186\/s12885-016-2743-x","article-title":"MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy","volume":"16","author":"BC Calhoun","year":"2016","journal-title":"BMC cancer"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/bcr2834","article-title":"Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis","volume":"13","author":"B Keam","year":"2011","journal-title":"Breast cancer research: BCR"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00428-010-1009-2","article-title":"Histopathological subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates","volume":"458","author":"M Miyashita","year":"2011","journal-title":"Virchows Archiv: an international journal of pathology"},{"key":"ref34","article-title":"Prognostic and predictive value of Ki-67 in triple-negative breast cancer","author":"W Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1186\/bcr3084","article-title":"Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer","volume":"14","author":"MA Aleskandarany","year":"2012","journal-title":"Breast cancer research: BCR"},{"issue":"22","key":"ref36","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/jnci\/djr393","article-title":"Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group","volume":"103","author":"M Dowsett","year":"2011","journal-title":"Journal of the National Cancer Institute"},{"issue":"6178","key":"ref37","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1251827","article-title":"Two decades after BRCA: setting paradigms in personalized cancer care and prevention","volume":"343","author":"FJ Couch","year":"2014","journal-title":"Science"},{"issue":"9291","key":"ref38","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(01)06524-2","article-title":"Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease","volume":"358","year":"2001","journal-title":"Lancet"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12885-016-2369-z","article-title":"Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison study","volume":"16","author":"R Moslehi","year":"2016","journal-title":"BMC cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T02:43:38Z","timestamp":1601693018000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172324"}},"subtitle":[],"editor":[{"given":"William B.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,24]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172324","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,24]]}}}