{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:55:38Z","timestamp":1788184538035,"version":"build-2803163510"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072713"],"award-info":[{"award-number":["81072713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172339","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T18:54:33Z","timestamp":1487357673000},"page":"e0172339","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Depressive disorder and gastrointestinal dysfunction after myocardial infarct are associated with abnormal tryptophan-5-hydroxytryptamine metabolism in rats"],"prefix":"10.1371","volume":"12","author":[{"given":"Xiaofang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e2815","DOI":"10.1097\/MD.0000000000002815","article-title":"Depression and the risk of myocardial infarction and coronary death: a meta-analysis of prospective cohort studies","volume":"95","author":"Q Wu","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1017\/S0007114511005137","article-title":"Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model","volume":"107","author":"J Arseneault-Br\u00e9ard","year":"2012","journal-title":"Br J Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.neuropharm.2012.07.047","article-title":"Serotonin 1A receptor agonist increases species- and region-selective adult CNS proliferation, but not through CNTF","volume":"63","author":"SA Arnold","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/j.gastro.2011.11.022","article-title":"Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome","volume":"142","author":"MB Larsson","year":"2012","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.11569\/wcjd.v21.i13.1226","article-title":"Influence of Wuji Wan indifferent compatibilities on colonic motility and 5-hydroxytryptamine contents in rats with post-infectious irritable bowel syndrome","volume":"21","author":"Y-H Wang","year":"2013","journal-title":"WCJD"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/hh1001.090842","article-title":"Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin","volume":"88","author":"NA Trueblood","year":"2001","journal-title":"Circ Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ejcts.2006.11.057","article-title":"Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction","volume":"31","author":"X Hu","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0008-6363(02)00594-1","article-title":"Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats","volume":"56","author":"R Nakamura","year":"2002","journal-title":"Cardiovasc Res"},{"key":"ref9","first-page":"11","article-title":"Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression","volume":"32","author":"BP Wann","year":"2007","journal-title":"J Psychiatry Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.9758\/cpn.2012.10.3.155","article-title":"Effects of chronic mild stress in female Bax Inhibitor-1-Gene knockout mice","volume":"10","author":"ZY Sui","year":"2012","journal-title":"Clin Psychopharm and Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1741-7015-11-32","article-title":"The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction","volume":"11","author":"Y Wang","year":"2013","journal-title":"BMC Medicine"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"e72428","DOI":"10.1371\/journal.pone.0072428","article-title":"Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats","volume":"27","author":"S Chen","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"e85348","DOI":"10.1371\/journal.pone.0085348","article-title":"1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats","volume":"9","author":"E Castilla-Ortega","year":"2014","journal-title":"PLoS One"},{"key":"ref14","first-page":"790","article-title":"Concentration increase in Hcy and anti-CCP antibody in the serum of depression rat model induced by chronic unpredictable mild stress","volume":"37","author":"Y Tang","year":"2012","journal-title":"J Cent South Univ (Med Sci)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e56053","DOI":"10.1371\/journal.pone.0056053","article-title":"Long-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of mice","volume":"8","author":"XC Ma","year":"2013","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S1734-1140(12)70936-2","article-title":"Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test","volume":"64","author":"Z Rog\u00f3\u017c","year":"2012","journal-title":"Pharmacol Rep"},{"key":"ref17","first-page":"3151","article-title":"The effect of shenlingbaizhu powder on gastrointestinal motility","volume":"12","author":"Z Zhang","year":"2009","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3382\/ps.2011-01779","article-title":"Effects of selective serotonin antagonism on central neurotransmission","volume":"91","author":"RL Dennis","year":"2012","journal-title":"Poult Sci"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-2094-8-17","article-title":"The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment","volume":"16","author":"AB Gold","year":"2011","journal-title":"J Neuroinflammation"},{"key":"ref20","article-title":"Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression","author":"J Grandjean","year":"2016","journal-title":"Neuroimage"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(69)91140-4","article-title":"Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect","volume":"1","author":"IP Lapin","year":"1969","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2174\/1389450111314050002","article-title":"Serotonin-kynurenine hypothesis of depression: historical overview and recent developments","volume":"14","author":"G Oxenkrug","year":"2013","journal-title":"Curr Drug Targets"},{"key":"ref23","first-page":"1","article-title":"Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function","volume":"8","author":"E Dale","year":"2015","journal-title":"CNS Spectr"},{"key":"ref24","first-page":"444","article-title":"Effect of acupuncture stimulation of different acupoint groups on levels of stress hormones and serum brain-derived neurotrophic factor in depression rats","volume":"40","author":"RX Shi","year":"2015","journal-title":"Zhen Ci Yan Jiu"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00964611","article-title":"L-kynurenine: its synthesis and possible regulatory function in brain","volume":"5","author":"EM G\u00e1l","year":"1980","journal-title":"Neurochem Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1403.003","article-title":"Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging","volume":"1122","author":"GF Oxenkrug","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4615-0135-0_14","article-title":"Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety","volume":"527","author":"IP Lapin","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2174\/1389450111314050002","article-title":"Serotonin-kynurenine hypothesis of depression: historical overview and recent developments","volume":"14","author":"G Oxenkrug","year":"2013","journal-title":"Curr Drug Targets"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00406-008-2012-3","article-title":"A psychoneuroimmunological perspective to Emil Kraepelin\u2019s dichotomy: schizophrenia and major depression as inflammatory CNS disorders","volume":"258","author":"N M\u00fcller","year":"2008","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.expneurol.2013.08.007","article-title":"The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain","volume":"249","author":"G Mazarei","year":"2013","journal-title":"Exp Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-61779-458-2_7","article-title":"Modeling depression in animal models","volume":"829","author":"DH Overstreet","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1073\/pnas.94.10.5308","article-title":"Differences between males and females in rates of serotonin synthesis in human brain","volume":"94","author":"S Nishizawa","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/0269881113499209","article-title":"Tryptophan: The key to boosting brain serotonin synthesis in depressive illness","volume":"27","author":"AA Badawy","year":"2013","journal-title":"J Psychopharmacol"},{"key":"ref34","first-page":"697","article-title":"Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-\u03b1 and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats","volume":"9","author":"BM Mohamed","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2982.2010.01664.x","article-title":"The microbiome-gut-brain axis: from bowel to behavior","volume":"23","author":"JF Cryan","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"ref36","first-page":"268","article-title":"Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense","volume":"123","author":"MD Gershon","year":"2012","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e24928","DOI":"10.1371\/journal.pone.0024928","article-title":"Serotonin augments gut pacemaker activity via 5-HT3 receptors","volume":"6","author":"HN Liu","year":"2011","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/MOG.0b013e328334df4f","article-title":"Enteric nervous system: sensory physiology, diarrhea and constipation","volume":"26","author":"JD Wood","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00018-007-7377-3","article-title":"Role of serotonin in the hepato-gastrointestinal tract: an old molecule for new perspectives","volume":"65","author":"M Lesurtel","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/intimm\/14.1.65","article-title":"Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells","volume":"14","author":"F Fallarino","year":"2002","journal-title":"Int Immunol"},{"key":"ref41","first-page":"1","article-title":"Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression","volume":"14","author":"E Won","year":"2015","journal-title":"Curr Neuropharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/MEG.0b013e328351c1c2","article-title":"Indoleamine 2,3-dioxygenase expression in human inflammatory bowel disease","volume":"24","author":"L Zhou","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jpsychores.2013.01.008","article-title":"Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: relation to serotonin and psychological state","volume":"4","author":"D Keszthelyi","year":"2013","journal-title":"J Psychosom Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/all.12802","article-title":"Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms","volume":"71","author":"S Georgin-Lavialle","year":"2016","journal-title":"Allergy"},{"key":"ref45","first-page":"1010","article-title":"Effect of various methods of oxygenation in the isolated small intestine on the tryptophan and glycine accumulation","volume":"89","author":"NA Basova","year":"2003","journal-title":"Ross Fiziol Zh Im I M Sechenova"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.genhosppsych.2011.02.007","article-title":"Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research","volume":"33","author":"A Meijer","year":"2011","journal-title":"Gen Hosp Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1155\/2012\/841792","article-title":"Safety of esophagogastroduodenoscopy within 30 days of myocardial infarction: a retrospective cohort study from a Canadian tertiary centre","volume":"26","author":"F Al-Ebrahim","year":"2012","journal-title":"Can J Gastroenterol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.npep.2012.08.005","article-title":"Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis","volume":"46","author":"P Holzer","year":"2012","journal-title":"Neuropeptides"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/10253890903067418","article-title":"Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour","volume":"13","author":"D O'Malley","year":"2010","journal-title":"Stress"},{"issue":"S3","key":"ref50","first-page":"8","article-title":"The gut-brain relationship","volume":"21","author":"AW Campbell","year":"2015","journal-title":"Altern Ther Health Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2170\/jjphysiol.48.333","article-title":"Plasma levels of 5-HT and 5-HIAA increased after intestinal ischemia\/reperfusion in rats","volume":"48","author":"Y Teramoto","year":"1998","journal-title":"Jpn J Physiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0021-9258(18)57137-4","article-title":"Serum vasoconstrictor (serotonin). IV. Isolation and characterization","volume":"176","author":"MM Rapport","year":"1948","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1358\/mf.2010.32.7.1507854","article-title":"The use of in situ perfusion of the rat mesentery as a model to investigate vascular injury directly induced by drugs","volume":"32","author":"AD Knapton","year":"2010","journal-title":"Methods Find Exp Clin Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T11:21:16Z","timestamp":1658661676000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172339"}},"subtitle":[],"editor":[{"given":"Alexandra","family":"Kavushansky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172339","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}