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Reiber","year":"1994","journal-title":"J Neurol Sci"},{"issue":"3","key":"ref78","first-page":"99","article-title":"Cerebrospinal fluid\u2014physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases","volume":"4","author":"H Reiber","year":"1998","journal-title":"Mult Scler"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(01)00573-3","article-title":"Dynamics of brain-derived proteins in cerebrospinal fluid","volume":"310","author":"H Reiber","year":"2001","journal-title":"Clin Chim Acta"},{"issue":"3\u20134","key":"ref80","first-page":"79","article-title":"Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics","volume":"21","author":"H Reiber","year":"2003","journal-title":"Restor Neurol Neurosci"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3940(01)01556-7","article-title":"Tau protein in 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