{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:59:56Z","timestamp":1787021996881,"version":"build-2736575974"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","award":["CASPAC"],"award-info":[{"award-number":["CASPAC"]}],"id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172407","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T13:53:40Z","timestamp":1487339620000},"page":"e0172407","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients \u2013 Data from the German Calciphylaxis Registry"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6576","authenticated-orcid":true,"given":"Hansj\u00f6rg","family":"Rothe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Brandenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Haun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kollerits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ketteler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/ndt\/gfs015","article-title":"Calciphylaxis in CKD and beyond","volume":"27","author":"VM Brandenburg","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2141.2011.08751.x","article-title":"Calciphylaxis, occurring 10 weeks after hypercalcaemia, in a patient with multiple myeloma","volume":"155","author":"E Sullivan","year":"2011","journal-title":"Br J Haematol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/00003072-199812000-00007","article-title":"Metastatic pulmonary, gastric, and renal calcification demonstrated on bone scintigraphy in a patient with malignant melanoma and renal failure","volume":"23","author":"D Wheat","year":"1998","journal-title":"Clin Nucl Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/DAD.0b013e3180ddb535","article-title":"Unusual case of calciphylaxis associated with metastatic breast carcinoma","volume":"29","author":"DS Bosler","year":"2007","journal-title":"Am J Dermatopathol"},{"key":"ref5","first-page":"1139","article-title":"CUA from non-uremic causes","volume":"3","author":"SU Nigwekar","year":"2008","journal-title":"A systematic review\u201d CJASN"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"080501","DOI":"10.1117\/1.JBO.20.8.080501","article-title":"Raman spectroscopy for label-free identification of CUA","volume":"20","author":"WR Lloyd","year":"2015","journal-title":"J Biomed. Opt"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.14309\/crj.2015.60","article-title":"CUA in a patient with alcoholic liver cirrhosis","volume":"9","author":"E Akhtar","year":"2015","journal-title":"ACG Case Rep J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1610-0387.2012.07947.x","article-title":"Calciphylaxis induced by acquired protein S deficiency in a patient with multiple myeloma\u2014effective treatment with low-molecular-weight heparin","volume":"10","author":"N Kerk","year":"2012","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2015.05.049","article-title":"Rapidly progressive non-uremic calciphyaxis in the setting of warfarin","volume":"128","author":"GH Bae","year":"2015","journal-title":"Am J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00467-003-1276-0","article-title":"CUA and vascular calcification: a continuum of extra-skeletal osteogenesis","volume":"18","author":"S Moe","year":"2003","journal-title":"Pediatr.Nephrol"},{"key":"ref11","article-title":"Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry","author":"VM Brandenburg","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00003086-197003000-00003","article-title":"The present status of calciphylaxis and calcergy","volume":"69","author":"H Selye","year":"1970","journal-title":"Clin Orthop Relat Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMoa0912923","article-title":"NT5E mutations and arterial calcifications","volume":"364","author":"C St. Hilaire","year":"2011","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","article-title":"Medial vascular calcification revisited: review and perspectives","volume":"35","author":"P Lanzer","year":"2014","journal-title":"European Heart Journal"},{"key":"ref15","first-page":"460654","article-title":"The roles of CD73 in cancer","author":"ZW Gao","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"97380","DOI":"10.1371\/journal.pone.0097380","article-title":"Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart","volume":"9","author":"TT Koopmann","year":"2014","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1073\/pnas.1519292113","article-title":": Dual function of C\/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing","volume":"113","author":"M Falaleeva","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/exd.12868","article-title":"Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma","volume":"25","author":"Y Ichigozaki","year":"2016","journal-title":"Exp Dermatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/0880010390158621","article-title":"Malignant melanoma of the soft parts showing calciphylaxis","volume":"20","author":"NO Kutlu","year":"2003","journal-title":"Pediatr Hematol Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1755-3768.2008.01231.x","article-title":"Spontaneous calcification of a choroidal melanoma","volume":"87","author":"B Cs\u00e1k\u00e1ny","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1148\/116.3.627","article-title":"Metastatic melanoma of the adrenal: an unusual cause of adrenal calcification","volume":"116","author":"J Twersky","year":"1975","journal-title":"Radiology"},{"key":"ref22","first-page":"339","article-title":"Extensive metastatic calcification in a case of malignant melanoma","volume":"4","author":"W Escovitz","year":"1950","journal-title":"Ann West Med Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1128\/IAI.00418-15","article-title":"Ecto-5&apos; -nucleotidase (CD73) deficiency in Mycobacterium tuberculosis-infected mice enhances neutrophil recruitment","volume":"83","author":"L Petit-Jentreau","year":"2015","journal-title":"Infect. Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1523\/JNEUROSCI.5324-09.2010","article-title":"Ecto-5&apos;-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits","volume":"30","author":"NA Sowa","year":"2010","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.4161\/15384101.2014.943567","article-title":"Juxta-articular joint-capsule mineralization in CD73 deficient mice: similarities to patients with NT5E mutations","volume":"13","author":"Q Li","year":"2014","journal-title":"Cell Cycle"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ymgme.2011.01.018","article-title":"Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum","volume":"103","author":"TC Markello","year":"2011","journal-title":"Mol Genet Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000211640","article-title":"Effect of vitamin D 3 and induced calciphylaxis on atherosclerosis of rabbits treated with cholesterol and calcium gluconate","volume":"14","author":"J Kudejko","year":"1968","journal-title":"Gerontologia"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/bju.12396","article-title":"Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk","volume":"114","author":"HJ Kim","year":"2014","journal-title":"BJU Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/opo.12131","article-title":"When to use the Bonferroni correction","volume":"34","author":"RA Armstrong","year":"2014","journal-title":"Ophthalmic Physiol Opt"},{"key":"ref30","article-title":"GeneReviews","author":"C Ferreira","year":"2014"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrneph.2011.91","article-title":"Mechanisms and treatment of extraosseous calcification in chronic kidney disease","volume":"19","author":"M Ketteler","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"10006","DOI":"10.1038\/ncomms10006","article-title":"ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy","volume":"6","author":"RA Albright","year":"2015","journal-title":"Nat Commun"},{"key":"ref33","article-title":"MicroRNAs in nociceptive circuits as predictors of future clinical applications","author":"M Kress","year":"2013","journal-title":"Front Mol Neurosci"},{"key":"ref34","first-page":"452","article-title":"Calciphylaxis. A call for interdisciplinary cooperation","volume":"62","author":"VM Brandenburg","year":"2011","journal-title":"Hautarzt"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.2146\/ajhp070546","article-title":"Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis","volume":"65","author":"CB Raymond","year":"2008","journal-title":"Am J Health Syst Pharm"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s00467-013-2746-7","article-title":"Ketteler M: Calcific uraemic arteriolopathy: a rare disease with a potentially high impact on chronic kidney disease\u2013mineral and bone disorder","volume":"29","author":"VM Brandenburg","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.semnephrol.2014.02.007","article-title":"Laboratory abnormalities in CKD-MBD: markers, predictors, or mediators of disease?","volume":"34","author":"P Evenepoel","year":"2014","journal-title":"Semin Nephrol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng.568","article-title":"Fox CS: New loci associated with kidney function and chronic kidney disease","volume":"42","author":"A K\u00f6ttgen","year":"2010","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.a.30680","article-title":"A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome","volume":"135","author":"DJ Hur","year":"2005","journal-title":"Am I Med Genet A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(03)12710-9","article-title":"Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study","volume":"361","author":"M Ketteler","year":"2003","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/ATVBAHA.111.230904","article-title":"Bone Gla protein increases HIF-1alpha-dependent glucose metabolism and induces cartilage and vascular calcification","volume":"31","author":"A Idelevich","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.3390\/nu7115443","article-title":"Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol","volume":"7","author":"LM Vossen","year":"2015","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bib\/bbl021","article-title":"Navigating the HapMap","volume":"7","author":"MR Barnes","year":"2006","journal-title":"Brief Bioinform"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/ije\/dyi169","article-title":"The choice of e genetic model in the meta-analysis of molecular association studies","volume":"34","author":"C Minelli","year":"2005","journal-title":"Int J Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T16:56:55Z","timestamp":1568825815000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172407"}},"subtitle":[],"editor":[{"given":"Rosa Maria Affonso","family":"Moys\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172407","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}