{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:46:38Z","timestamp":1759959998155,"version":"3.37.3"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["DINTER"],"award-info":[{"award-number":["DINTER"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (BR)"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172525","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T18:46:00Z","timestamp":1488393960000},"page":"e0172525","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety evaluation of a vaccine: Effect in maternal reproductive outcome and fetal anomaly frequency in rats using a leishmanial vaccine as a model"],"prefix":"10.1371","volume":"12","author":[{"given":"Rafaianne Q.","family":"Moraes-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Reinaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaigra S.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luiza T.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo C.","family":"Giunchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A. S.","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena A.","family":"Akamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via S.","family":"Kubrusly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"L\u00facio-Macarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaias","family":"Raw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitri","family":"Iourtov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Lee","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian L.","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo T.","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo T.","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"issue":"Suppl 1","key":"ref1","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1111\/trf.13344","article-title":"Transfusion-transmitted leishmaniasis: a practical review","volume":"56","author":"T Jimenez-Marco","year":"2016","journal-title":"Transfusion"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/1064744042000210384","article-title":"Visceral leishmaniasis (kala-azar) in pregnancy","volume":"12","author":"EA Figueir\u00f3-Filho","year":"2004","journal-title":"Infect Dis Obstet Gynecol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid1202.050449d","article-title":"Congenital visceral leishmaniasis","volume":"12","author":"CC Boehme","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"J Alvar","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0020-7519(00)00136-3","article-title":"The leishmaniases as emerging and reemerging zoonoses","volume":"30","author":"RW Ashford","year":"2000","journal-title":"Int J Parasitol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"P Desjeux","year":"2004","journal-title":"Com Immunol Microbiol Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1038\/nrmicro1766","article-title":"Evaluation of Rapid Diagnostic Tests: Visceral Leishmaniasis","volume":"1","author":"M Boelart","year":"2007","journal-title":"Nature Rev. Microbiol"},{"issue":"4","key":"ref8","first-page":"1063","article-title":"Vacinas e Gravidez","volume":"24","author":"MV Tavares","year":"2011","journal-title":"Acta Med Port"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0001-706X(03)00160-8","article-title":"Visceral leishmaniosis in pregnancy: a case report","volume":"88","author":"AJ Caldas","year":"2003","journal-title":"Acta Trop"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00404-007-0532-0","article-title":"Visceral leishmaniasis and pregnancy: analysis of cases reported in a central-western region of Brazil","volume":"278","author":"EA Figueir\u00f3-Filho","year":"2008","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/jac\/dkl342","article-title":"A comparison of liposomal amphotericin B with sodium stibogluconate for the treatment of visceral leishmaniasis in pregnancy in Sudan","volume":"58","author":"M Mueller","year":"2006","journal-title":"J Antimicrob Chemother"},{"issue":"52","key":"ref12","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1016\/j.vaccine.2014.09.052","article-title":"Safety of immunization during pregnancy: a review of the evidence of selected inactivated and live attenuated vaccines","volume":"32","author":"B Keller-Stanislawski","year":"2014","journal-title":"Vaccine"},{"key":"ref13","first-page":"1","article-title":"Ending preventable maternal and newborn deaths due to infection","volume":"16","author":"M Desale","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"894","key":"ref14","first-page":"1","article-title":"Dismantling the Taboo against Vaccines in Pregnancy","volume":"17","author":"M Martino","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"31","key":"ref15","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1016\/j.vaccine.2009.04.047","article-title":"Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice","volume":"27","author":"W Quintilio","year":"2009","journal-title":"Vaccine"},{"issue":"13","key":"ref16","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.vaccine.2010.01.044","article-title":"Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations","volume":"28","author":"C Miyaki","year":"2010","journal-title":"Vaccine"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1128\/IAI.01169-13","article-title":"Invasion-inhibitory antibodies elicited by immunization with Plasmodium vivax apical membrane antigen-1 expressed in Pichia pastoris yeast","volume":"82","author":"EC Vicentin","year":"2014","journal-title":"Infect Immun"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"e3391","DOI":"10.1371\/journal.pntd.0003391","article-title":"DNA-Protein immunization using leishmania peroxidoxin-1 induces a strong CD4+ T cell response and partially protects mice from cutaneous leishmaniasis: Role of fusion murine granulocyte-macrophage colony-stimulating factor DNA adjuvant","volume":"8","author":"AG Bayih","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"348401","DOI":"10.1155\/2015\/348401","article-title":"Differential immune response against recombinant Leishmania donovani peroxidoxin 1 and peroxidoxin 2 proteins in BALB\/c mice","volume":"2015","author":"NS Daifalla","year":"2015","journal-title":"J Immunol Res"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"e99216","DOI":"10.1371\/journal.pone.0099216","article-title":"Mapping B-cell epitopes for the peroxidoxin of Leishmania (Viannia) braziliensis and its potential for the clinical diagnosis of tegumentary and visceral leishmaniasis","volume":"9","author":"D Menezes-Souza","year":"2014","journal-title":"PLoS One"},{"issue":"31","key":"ref21","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1016\/j.vaccine.2009.04.047","article-title":"Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice","volume":"27","author":"W Quintilio","year":"2009","journal-title":"Vaccine"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/bdrb.21152","article-title":"Effect of Himatanthus sucuuba in maternal reproductive outcome and fetal anomaly frequency in rats","volume":"104","author":"TS Soares","year":"2015","journal-title":"Birth Defects Res. B Dev. Reprod Toxicol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12192-015-0581-4","article-title":"Extracellular HSP70 levels in diabetic environment in rats","volume":"20","author":"TM Santos","year":"2015","journal-title":"Cell Stress Chaperones"},{"key":"ref24","first-page":"247","article-title":"Farbemethode zum markroskopishen nachweis von implantatconsstellen an uterus der ratter naunyn schmuderbergs","author":"E Salewski","year":"1964","journal-title":"N-S. Arch. Pharmacol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/0001-3765201520140354","article-title":"Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats","volume":"87","author":"GT Volpato","year":"2015","journal-title":"An Acad Bras Cienc"},{"first-page":"262","article-title":"Teratology: Principles and Techniques","author":"JG Wilson","key":"ref26"},{"key":"ref27","first-page":"61","article-title":"Refinements in rapid clearing technique in the KOH alizarin red S method for fetal bone","volume":"39","author":"RE Staples","year":"1964","journal-title":"Stain Technol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/tera.1420200208","article-title":"The extent of fetal ossification as an index of delayed development in teratogenic studies on the rat","volume":"20","author":"V Aliverti","year":"1979","journal-title":"Teratol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/261878","article-title":"Validation of the Friedewald Formula in Patients with Metabolic Syndrome","volume":"2014","author":"J Knopfholz","year":"2014","journal-title":"Cholesterol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1373\/clinchem.2012.182543","article-title":"Quantifying the accuracy of a diagnostic test or marker","volume":"58","author":"K Linnet","year":"2012","journal-title":"Clin Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1586\/14760584.2014.894467","article-title":"Identifying vaccine targets for anti-leishmanial vaccine development","volume":"13","author":"S Sundar","year":"2014","journal-title":"Expert Rev. Vaccines"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1590\/S0100-879X2012007500142","article-title":"Recombinant vaccines and the development of new vaccine strategies","volume":"45","author":"IP Nascimento","year":"2012","journal-title":"Braz. J. Med. Biol. Res"},{"key":"ref33","first-page":"42","article-title":"NEME, B. Obstetr\u00edcia b\u00e1sica","author":"MVC Rudge","year":"2000"},{"year":"1996","key":"ref34","article-title":"OPPTS Harmonized Test Guidelines"},{"key":"ref35","first-page":"989","article-title":"Principles and methods of toxicology","author":"JM Manson","year":"1994"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1078\/094471102321616508","article-title":"Effects of Annona squamosa extract on early pregnancy in rats","volume":"9","author":"DC Damasceno","year":"2002","journal-title":"Phytomed"},{"article-title":"Risk assessment of prenatally-induced advers healh effects","year":"1992","author":"D Neubert","key":"ref37"},{"article-title":"Anomalias Cong\u00eanitas: Estudos Experimentais","year":"2008","author":"DC Damasceno","key":"ref38"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.151.9.4562","article-title":"Synthesis of T helper 2-type cytokines at the maternal-fetal interface","volume":"151","author":"H Lin","year":"1993","journal-title":"J Immunol"},{"issue":"2","key":"ref40","first-page":"145","article-title":"Imunologia da Gesta\u00e7\u00e3o","volume":"50","author":"T Michelon","year":"2006","journal-title":"Revista da AMRIGS"},{"key":"ref41","first-page":"355","article-title":"Aspectos da imunologia da gravidez","volume":"20","author":"S Sarafana","year":"2007","journal-title":"Acta Med Port"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000245927","article-title":"Endocrine regulation of feto-placental growth","volume":"72","author":"AL Fowden","year":"2009","journal-title":"Horm Res"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1590\/S0100-879X2005000400010","article-title":"Relationships between fetal body weight of Wistar rats at term and the extent of skeletal ossification","volume":"38","author":"I Chahoud","year":"2005","journal-title":"Braz J Med Biol Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0890-6238(99)00035-0","article-title":"Correlation between maternal toxicity and embryo\/fetal effects","volume":"13","author":"I Chahoud","year":"1999","journal-title":"Reprod Toxicol"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Solecki R, Barbellion S, Bergmann B, B\u00fcrgin H, Buschmann J, Clark R, et al. Harmonization of description and classification of fetal observations: Achievements and still standing problems. Report of the 7th Workshop on the Terminology in Developmental Toxicology Berlin, 4\u20136 May 2011. Reprod Toxicol. 2013; 35: 48\u201355.","DOI":"10.1016\/j.reprotox.2012.06.006"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Solecki R, Bergmann B, B\u00fcrgin H, Buschmann J, Clark R, Druga A, et al. Harmonization of rat fetal external and visceral terminology and classification Report of the Fourth Workshop on the Terminology in Developmental Toxicology, Berlin, 18\u201320 April 2002. Reprod Toxicol. 2003; 17: 625\u201337.","DOI":"10.1016\/S0890-6238(03)00092-3"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.siny.2008.11.001","article-title":"Congenital anomalies in diabetic pregnancy","volume":"14","author":"UJ Eriksson","year":"2009","journal-title":"Semin Fetal Neonatal Med"},{"issue":"10","key":"ref48","first-page":"541","article-title":"Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol","volume":"26","author":"M Hod","year":"1990","journal-title":"Isr J Med Sci"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2337\/diab.35.12.1356","article-title":"Increased accumulation of sorbitol in offspring of manifest diabetic rats","volume":"35","author":"UJ Eriksson","year":"1986","journal-title":"Diabetes"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/tera.1420330110","article-title":"Yolk sac failure in embryopathy due to hyperglycemia. Ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic condition","volume":"33","author":"E Pinter","year":"1986","journal-title":"Teratology"},{"issue":"8","key":"ref51","first-page":"469","article-title":"Biochemical basis of the diabetic embryophaty","volume":"27","author":"AS Goldman","year":"1991","journal-title":"Isr J Med Sci"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/0002-9378(95)91323-8","article-title":"Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos","volume":"173","author":"ZJ Hagay","year":"1995","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-4320(02)00094-5","article-title":"Oxidative stress and diabetes in pregnant rats","volume":"72","author":"DC Damasceno","year":"2002","journal-title":"Anim Reprod Sci"},{"issue":"36","key":"ref54","doi-asserted-by":"crossref","first-page":"34279","DOI":"10.1074\/jbc.M104406200","article-title":"Cloning and characterization of three differentially expressed peroxidoxin genes from Leishmania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals","volume":"276","author":"SD Barr","year":"2001","journal-title":"J Biol Chem"},{"issue":"12","key":"ref55","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1074\/jbc.M212990200","article-title":"Role of peroxidoxins in Leishmania chagasi survival. Evidence of an enzymatic defense against nitrosative stress","volume":"278","author":"SD Barr","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/1381612043452866","article-title":"The role of ROS and RNS in regulating life and death of blood monocytes","volume":"10","author":"CP Baran","year":"2004","journal-title":"Curr Pharm Des"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:25:27Z","timestamp":1692707127000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172525"}},"subtitle":[],"editor":[{"given":"Henk D. F. H.","family":"Schallig","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172525","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}