{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:08:07Z","timestamp":1790834887905,"version":"4.1.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172821","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T18:57:45Z","timestamp":1488481065000},"page":"e0172821","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["Tissue-specific regulation of CXCL9\/10\/11 chemokines in keratinocytes: Implications for oral inflammatory disease"],"prefix":"10.1371","volume":"12","author":[{"given":"Alison","family":"Marshall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","article-title":"Cellular responses to interferon-gamma","volume":"15","author":"U Boehm","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12026-012-8362-y","article-title":"Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections","volume":"55","author":"S Kearney","year":"2013","journal-title":"Immunol Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411010120020301","article-title":"Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption","volume":"12","author":"MA Taubman","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1600-0714.2003.00077.x","article-title":"Th1 cytokines in oral lichen planus","volume":"32","author":"A Khan","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-2776(01)78002-9","article-title":"Chemokines in immunity","volume":"78","author":"O Yoshie","year":"2001","journal-title":"Adv immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1152\/ajpregu.00738.2001","article-title":"Chemokines and chemokine receptors in leukocyte trafficking","volume":"283","author":"TS Olsen","year":"2002","journal-title":"Am j Physiol reg int comp physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1073\/pnas.90.8.3574","article-title":"Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg","volume":"90","author":"I Clark-Lewis","year":"1993","journal-title":"Proceedings of the National Academy of Science USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3696::AID-IMMU3696>3.0.CO;2-W","article-title":"Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization","volume":"28","author":"M Loetscher","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1046\/j.1523-1747.1999.00581.x","article-title":"Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10\/Mig receptor (CXCR3)","volume":"112","author":"CP Tensen","year":"1999","journal-title":"J Invest Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1124\/mol.59.4.707","article-title":"Human interferon-inducible 10kDa protein and human interferon-inducible T cell \u03b1 chemoattractant are allotropic ligands for human CXCR3: differential binding to receptor states","volume":"59","author":"MA Cox","year":"2000","journal-title":"Mol Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.4049\/jimmunol.162.7.3840","article-title":"Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling","volume":"162","author":"RL Rabin","year":"1999","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nm0598-627","article-title":"B cells inhibit induction of T cell-dependent tumor immunity","volume":"4","author":"Z Qin","year":"1998","journal-title":"Nat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0167-5699(98)01346-2","article-title":"Chemokines and chemokine receptors in T-cell priming and Th1\/ Th2-mediated responses","volume":"19","author":"F Sallusto","year":"1998","journal-title":"Immunology Today"},{"key":"ref14","article-title":"CXCR3 ligands in disease and therapy","volume":"22","author":"K Van Raemdonck","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/1521-4141(200108)31:8<2521::AID-IMMU2521>3.0.CO;2-Q","article-title":"Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection","volume":"31","author":"M Meyer","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.162.8.4928","article-title":"Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils","volume":"162","author":"S Gasperini","year":"1999","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.4049\/jimmunol.164.10.5383","article-title":"Expression of IFN-inducible T cell alpha chemoattractant by human endothelial cells is cyclosporin A-resistant and promotes T cell adhesion: implications for cyclosporin A-resistant immune inflammation","volume":"164","author":"MM Mazanet","year":"2000","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1177\/154405910808701211","article-title":"Regulation of CXCL9\/10\/11 in oral keratinocytes and fibroblasts","volume":"87","author":"K Ohta","year":"2008","journal-title":"J Dent Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.4049\/jimmunol.162.6.3549","article-title":"T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells","volume":"162","author":"A Sauty","year":"1999","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0002-9440(10)64171-5","article-title":"Expression of IP-10\/CXCL10 and MIG\/CXCL9 in the thyroid and increased levels of IP-10\/CXCL10 in the serum of patients with recent-onset Graves&apos; disease","volume":"161","author":"P Romagnani","year":"2002","journal-title":"Am J Path"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2009.01.008","article-title":"Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-gamma-stimulated CXCL9-11 production in intestinal epithelial cells","volume":"123","author":"S Kawaguchi","year":"2009","journal-title":"Immunol Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1189\/jlb.70.4.617","article-title":"A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases","volume":"70","author":"C Albanesi","year":"2001","journal-title":"J Leukoc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/eji.200636420","article-title":"IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes","volume":"37","author":"N Kanda","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/bj20030842","article-title":"Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines","volume":"376","author":"M Hiroi","year":"2003","journal-title":"Biochem J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.4049\/jimmunol.167.6.3494","article-title":"Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection","volume":"167","author":"M Miura","year":"2001","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.cca.2012.02.009","article-title":"CXCL10: a candidate biomarker in transplantation","volume":"413","author":"P Romagnani","year":"2012","journal-title":"Clin Chim Acta"},{"key":"ref27","first-page":"1719","article-title":"T cell attractant chemokine expression initiates lacrimal gland destruction in non-obese diabetic mice","volume":"79","author":"J Tornwall","year":"1999","journal-title":"Laboratory Investigation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.autrev.2013.10.010","article-title":"Chemokine (C\u2013X\u2013C motif) ligand (CXCL)10 in autoimmune diseases","volume":"13","author":"A Antonelli","year":"2014","journal-title":"Autoimmun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/ibd.21312","article-title":"Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease","volume":"16","author":"S Schroepf","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.4049\/jimmunol.168.10.5278","article-title":"IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma","volume":"168","author":"BD Medoff","year":"2002","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/1096-9896(200108)194:4<397::AID-PATH899>3.0.CO;2-S","article-title":"Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation","volume":"194","author":"J Flier","year":"2001","journal-title":"J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9440(10)63986-7","article-title":"Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity","volume":"158","author":"M Goebeler","year":"2001","journal-title":"Am J Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0923-1811(01)00172-4","article-title":"Dominant expression of CXCR3 is associated with induced expression of IP-10 at hapten-challenged sites of murine contact hypersensitivity: a possible role for interferon-gamma-producing CD8(+) T cells in IP-10 expression","volume":"28","author":"A Tokuriki","year":"2002","journal-title":"J Dermatol Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1046\/j.1523-1747.2002.01771.x","article-title":"Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis","volume":"118","author":"S Sebastiani","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1038\/jid.2008.96","article-title":"An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in &quot;interface dermatitis&quot;","volume":"128","author":"J Wenzel","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1523-1747.1998.00426.x","article-title":"MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions","volume":"111","author":"U Spandau","year":"1998","journal-title":"J Invest Dermatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1600-0560.2006.00527.x","article-title":"Type I interferon-associated cytotoxic inflammation in lichen planus","volume":"33","author":"J Wenzel","year":"2006","journal-title":"J Cutan Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-0714.2006.00402.x","article-title":"Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus","volume":"35","author":"M Ichimura","year":"2006","journal-title":"J Oral Pathol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1365-2249.2001.01511.x","article-title":"Chemokines in human periodontal disease tissues","volume":"125","author":"E Gemmell","year":"2001","journal-title":"Clinic Experim Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/10454411980090010501","article-title":"Update on oral lichen planus: etiopathogenesis and management","volume":"9","author":"C Scully","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/path.1711600313","article-title":"The behaviour of human oral squamous cell carcinoma in cell culture","volume":"160","author":"SS Prime","year":"1990","journal-title":"J Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.4049\/jimmunol.162.7.4140","article-title":"Hess S. CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma","volume":"162","author":"A Altenburg","year":"1999","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jep.2008.11.024","article-title":"Effect of Pinus massoniana bark extract on IFN-gamma-induced ICAM-1 expression in HaCaT human keratinocytes","volume":"122","author":"C Wu","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/15419060009015003","article-title":"Combined interferon-gamma and tumor necrosis factor-alpha treatment differentially affects adhesion and migration of keratinocyte-derived cells to laminin-1","volume":"7","author":"FA van den Br\u00fble","year":"2000","journal-title":"Cell Adhes Commun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-0625.1998.tb00320.x","article-title":"CD24 expression on human keratinocytes","volume":"7","author":"P Redondo","year":"1998","journal-title":"Exp Dermatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/1348-0421.12022","article-title":"Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts viaToll-like receptors","volume":"57","author":"A Fukui","year":"2013","journal-title":"Microbiol Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.165.3.1395","article-title":"IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines","volume":"165","author":"C Albanesi","year":"2000","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/gast.2001.20914","article-title":"Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells","volume":"120","author":"MB Dwinell","year":"2001","journal-title":"Gastroenterology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1084\/jem.187.12.2009","article-title":"Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3","volume":"187","author":"KE Cole","year":"1998","journal-title":"J Exp Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s004030050314","article-title":"Chemokine IP-10 expression in cultured human keratinocytes","volume":"290","author":"DM Boorsma","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2010.158","article-title":"CXCR3 ligands: redundant, collaborative and antagonistic functions","volume":"89","author":"JR Groom","year":"2011","journal-title":"Immunol Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/jdv.12027","article-title":"Autoantibodies and decreased expression of the transcription factor ELF-3 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral mucosa","volume":"27","author":"K Danielsson","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/cyto.2002.1985","article-title":"The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues","volume":"20","author":"H Kabashima","year":"2002","journal-title":"Cytokine"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1074\/jbc.M005652200","article-title":"The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP-10, are natural antagonists for CCR3","volume":"276","author":"P Loetscher","year":"2001","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4049\/jimmunol.167.2.623","article-title":"Cutting Edge: IFN-Inducible ELR- CXC chemokines display defensin-like antimicrobial activity","volume":"167","author":"AM Cole","year":"2001","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/000163501750266774","article-title":"Immune mechanisms in oral lichen planus","volume":"59","author":"MH Thornhill","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0002-9440(10)65699-4","article-title":"Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing","volume":"153","author":"E Engelhardt","year":"1998","journal-title":"Am J Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:56:25Z","timestamp":1692708985000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172821"}},"subtitle":[],"editor":[{"given":"Paul","family":"Proost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172821","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}