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biology"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"e0139179","DOI":"10.1371\/journal.pone.0139179","article-title":"The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-beta-Induced Epithelial to Mesenchymal Transition","volume":"10","author":"M Ruff","year":"2015","journal-title":"PLoS One"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1365-2443.2005.00902.x","article-title":"Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage","volume":"10","author":"M Naitoh","year":"2005","journal-title":"Genes Cells"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.ajpath.2011.06.034","article-title":"Identification and characterization of cartilage oligomeric matrix protein as a novel pathogenic factor in keloids","volume":"179","author":"S Inui","year":"2011","journal-title":"Am J Pathol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.matbio.2013.02.010","article-title":"Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies","volume":"32","author":"P Agarwal","year":"2013","journal-title":"Matrix Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1365-2133.2011.10215.x","article-title":"Collagen triple helix repeat containing-1 inhibits transforming growth factor-b1-induced collagen type I expression in keloid","volume":"164","author":"J Li","year":"2011","journal-title":"Br J Dermatol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1165\/rcmb.2013-0310OC","article-title":"A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis","volume":"52","author":"Y Bauer","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tcm.2007.05.004","article-title":"The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling","volume":"17","author":"R LeClair","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"ref94","article-title":"Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression","author":"J Eriksson","year":"2016","journal-title":"Oncotarget"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.3892\/mmr.2016.4833","article-title":"MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma","volume":"13","author":"CY Wang","year":"2016","journal-title":"Mol Med Rep"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.3892\/or.2015.3791","article-title":"Asporin participates in gastric cancer cell growth and migration by influencing EGF receptor signaling","volume":"33","author":"Q Ding","year":"2015","journal-title":"Oncol Rep"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/1078-0432.CCR-15-0256","article-title":"Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer","volume":"22","author":"PJ Hurley","year":"2016","journal-title":"Clin Cancer Res"},{"key":"ref98","first-page":"e24","article-title":"Identification of novel keloid biomarkers through profiling of tissue biopsies versus cell cultures in keloid margin specimens compared to adjacent normal skin","volume":"10","author":"B Shih","year":"2010","journal-title":"Eplasty"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.trsl.2015.09.006","article-title":"Wnt pathway in Dupuytren disease: connecting profibrotic signals","volume":"166","author":"MM van Beuge","year":"2015","journal-title":"Transl Res"},{"key":"ref100","first-page":"29","article-title":"Wnt-induced secreted protein 1\/CCN4 in liver fibrosis both in vitro and in vivo","volume":"60","author":"YC Jian","year":"2014","journal-title":"Clin Lab"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biocel.2014.06.011","article-title":"miR-92a regulates TGF-beta1-induced WISP1 expression in pulmonary fibrosis","volume":"53","author":"B Berschneider","year":"2014","journal-title":"The international journal of biochemistry & cell biology"},{"key":"ref102","article-title":"Keloids: The paradigm of skin fibrosis\u2014Pathomechanisms and treatment","author":"JP Andrews","year":"2016","journal-title":"Matrix Biol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2133.2012.11023.x","article-title":"FK506 inhibits the enhancing effects of transforming growth factor (TGF)-beta1 on collagen expression and TGF-beta\/Smad signalling in keloid fibroblasts: implication for new therapeutic approach","volume":"167","author":"CS Wu","year":"2012","journal-title":"Br J Dermatol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/CCO.0b013e32835b6371","article-title":"TGF-beta signaling and epithelial-mesenchymal transition in cancer progression","volume":"25","author":"Y Katsuno","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceb.2014.09.001","article-title":"Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition","volume":"31","author":"R Derynck","year":"2014","journal-title":"Curr Opin Cell Biol"},{"key":"ref106","article-title":"Cancer biology: TGF [beta] and EMT as double agents","author":"P Strzyz","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2016.01.009","article-title":"TGF-\u03b2 Tumor Suppression through a Lethal EMT","volume":"164","author":"CJ David","year":"2016","journal-title":"Cell"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4939-2966-5_9","article-title":"Analysis of Epithelial\u2013Mesenchymal Transition Induced by Transforming Growth Factor \u03b2","author":"U Valcourt","year":"2016","journal-title":"TGF-\u03b2 Signaling: Methods and Protocols"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.jid.5700701","article-title":"Inflammation in wound repair: molecular and cellular mechanisms","volume":"127","author":"SA Eming","year":"2007","journal-title":"The Journal of investigative dermatology"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/wrr.12381","article-title":"Exacerbated and prolonged inflammation impairs wound healing and increases scarring","volume":"24","author":"LW Qian","year":"2016","journal-title":"Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"e3082","DOI":"10.1097\/MD.0000000000003082","article-title":"Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals","volume":"95","author":"M Zhang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3892\/br.2013.169","article-title":"Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)","volume":"1","author":"X Dong","year":"2013","journal-title":"Biomed Rep"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40139-015-0091-1","article-title":"IL-13 and TGF-\u03b21: Core Mediators of Fibrosis","volume":"3","author":"LA Borthwick","year":"2015","journal-title":"Current Pathobiology Reports"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13075-015-0708-0","article-title":"Transforming growth factor-beta increases interleukin-13 synthesis via GATA-3 transcription factor in T-lymphocytes from patients with systemic sclerosis","volume":"17","author":"J Baraut","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0022-3565(24)35380-7","article-title":"Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts","volume":"292","author":"A Oriente","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2015.05.023","article-title":"Commentary: IL-4 and IL-13 receptors and signaling","volume":"75","author":"SM McCormick","year":"2015","journal-title":"Cytokine"},{"key":"ref117","first-page":"2015","article-title":"IL13RA2 gene polymorphisms are associated with systemic sclerosis","volume":"33","author":"B Granel","year":"2006","journal-title":"J Rheumatol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.20020903","article-title":"Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response","volume":"197","author":"MG Chiaramonte","year":"2003","journal-title":"J Exp Med"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20020906","article-title":"Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2","volume":"197","author":"N Wood","year":"2003","journal-title":"J Exp Med"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4049\/jimmunol.178.1.511","article-title":"IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome","volume":"178","author":"MP Keane","year":"2007","journal-title":"J Immunol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.4049\/jimmunol.172.7.4068","article-title":"Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts","volume":"172","author":"JE Kolodsick","year":"2004","journal-title":"J Immunol"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.imbio.2015.09.009","article-title":"Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-alpha, IL-beta, IL-6 and IL-17A","volume":"221","author":"R Charrad","year":"2016","journal-title":"Immunobiology"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/cei.12061","article-title":"Epithelial expression of interleukin-37b in inflammatory bowel disease","volume":"172","author":"H Imaeda","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cyto.2007.09.009","article-title":"Regulation of IL-17 production in human lymphocytes","volume":"41","author":"Z Chen","year":"2008","journal-title":"Cytokine"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1158\/0008-5472.CAN-15-0054","article-title":"IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment","volume":"75","author":"L Benevides","year":"2015","journal-title":"Cancer Res"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2015.04.006","article-title":"Interleukin-17 and innate immunity in infections and chronic inflammation","volume":"60","author":"N Isailovic","year":"2015","journal-title":"J Autoimmun"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"e81983","DOI":"10.1371\/journal.pone.0081983","article-title":"Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature","volume":"8","author":"L Loubaki","year":"2013","journal-title":"PloS one"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.mehy.2013.08.033","article-title":"Pathological niche environment transforms dermal stem cells to keloid stem cells: a hypothesis of keloid formation and development","volume":"81","author":"M Qu","year":"2013","journal-title":"Med Hypotheses"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1476-4598-10-150","article-title":"IL-17 induces AKT-dependent IL-6\/JAK2\/STAT3 activation and tumor progression in hepatocellular carcinoma","volume":"10","author":"FM Gu","year":"2011","journal-title":"Mol Cancer"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s13277-012-0628-4","article-title":"Downregulation of IL-17-producing T cells is associated with regulatory T cell expansion and disease progression in chronic lymphocytic leukemia","volume":"34","author":"F Jadidi-Niaragh","year":"2013","journal-title":"Tumour Biol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.08.003","article-title":"B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis","volume":"56","author":"A Francois","year":"2015","journal-title":"J Autoimmun"},{"key":"ref132","first-page":"385","article-title":"IL-17 expression is correlated with hepatitis Brelated liver diseases and fibrosis","volume":"27","author":"L Wang","year":"2011","journal-title":"Int J Mol Med"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1002\/art.34643","article-title":"Potential roles of interleukin-17A in the development of skin fibrosis in mice","volume":"64","author":"Y Okamoto","year":"2012","journal-title":"Arthritis & Rheumatism"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1038\/sj.onc.1208259","article-title":"The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis","volume":"23","author":"S Nittka","year":"2004","journal-title":"Oncogene"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cncr.21159","article-title":"Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma","volume":"104","author":"PV Cruz","year":"2005","journal-title":"Cancer"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1053\/hupa.2002.32218","article-title":"Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition","volume":"33","author":"C Busch","year":"2002","journal-title":"Hum Pathol"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1158\/0008-5472.CAN-04-0505","article-title":"Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer","volume":"64","author":"L Oliveira-Ferrer","year":"2004","journal-title":"Cancer Res"},{"key":"ref138","article-title":"SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells","author":"S Ashkenazi","year":"2016","journal-title":"Oncotarget"},{"key":"ref139","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1038\/onc.2008.331","article-title":"CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium","volume":"27","author":"H Zalzali","year":"2008","journal-title":"Oncogene"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/ibd.21023","article-title":"Defect in CEACAM family member expression in Crohn&apos;s disease IECs is regulated by the transcription factor SOX9","volume":"15","author":"G Roda","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"926","DOI":"10.4161\/cc.5.9.2714","article-title":"ATF3 regulates the stability of p53: a link to cancer","volume":"5","author":"C Yan","year":"2006","journal-title":"Cell Cycle"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/1471-2407-10-668","article-title":"Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition","volume":"10","author":"C Hackl","year":"2010","journal-title":"BMC Cancer"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijcard.2016.01.143","article-title":"Pleiotropic and puzzling effects of ATF3 in maladaptive cardiac remodeling","volume":"206","author":"H Zhou","year":"2016","journal-title":"Int J Cardiol"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"29795","DOI":"10.1074\/jbc.M802515200","article-title":"KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3","volume":"283","author":"X Huang","year":"2008","journal-title":"The Journal of biological chemistry"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.18632\/oncotarget.2322","article-title":"ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma","volume":"5","author":"JJ Xie","year":"2014","journal-title":"Oncotarget"},{"key":"ref146","first-page":"14","article-title":"In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells","author":"HJ Eo","year":"2016","journal-title":"Mar Drugs"},{"key":"ref147","article-title":"TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth","author":"S Jiliang","year":"2016","journal-title":"Oncotarget"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4062\/biomolther.2015.109","article-title":"Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer","volume":"24","author":"HM Song","year":"2016","journal-title":"Biomol Ther (Seoul)"},{"key":"ref149","doi-asserted-by":"crossref","first-page":"24122","DOI":"10.1074\/jbc.M112.343608","article-title":"Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes","volume":"287","author":"R Meech","year":"2012","journal-title":"The Journal of biological chemistry"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1124\/mol.110.069336","article-title":"The novel UDP glycosyltransferase 3A2: cloning, catalytic properties, and tissue distribution","volume":"79","author":"PI MacKenzie","year":"2011","journal-title":"Mol Pharmacol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cbi.2015.02.005","article-title":"Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo-keto reductase 1B10","volume":"230","author":"Y Morikawa","year":"2015","journal-title":"Chem Biol Interact"},{"key":"ref152","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.biopha.2013.04.005","article-title":"The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance","volume":"67","author":"R Januchowski","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/bcj.2012.17","article-title":"Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy","volume":"2","author":"AH Nwabo Kamdje","year":"2012","journal-title":"Blood Cancer J"},{"key":"ref154","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.celrep.2015.08.050","article-title":"Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity","volume":"12","author":"BM Simoes","year":"2015","journal-title":"Cell Rep"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3892\/or_00000885","article-title":"Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance","volume":"24","author":"K Honoki","year":"2010","journal-title":"Oncol Rep"},{"key":"ref156","unstructured":"Whitman M, Hunter DG, Engle EC. Congenital Fibrosis of the Extraocular Muscles. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, et al., editors. GeneReviews(R). Seattle (WA)1993."},{"key":"ref157","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/cm.20436","article-title":"Tumoral and tissue-specific expression of the major human beta-tubulin isotypes","volume":"67","author":"LJ Leandro-Garcia","year":"2010","journal-title":"Cytoskeleton (Hoboken)"},{"key":"ref158","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3892\/ol.2016.4206","article-title":"High levels of class III beta-tubulin expression are associated with aggressive tumor features in breast cancer","volume":"11","author":"P Lebok","year":"2016","journal-title":"Oncol Lett"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/DAD.0b013e3181cd35e0","article-title":"Immunohistochemical study of HER2 and TUBB3 proteins in extramammary Paget disease","volume":"32","author":"A Miyamoto","year":"2010","journal-title":"Am J Dermatopathol"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1158\/0008-5472.CAN-14-2740","article-title":"TUBB3\/betaIII-tubulin acts through the PTEN\/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer","volume":"75","author":"JA McCarroll","year":"2015","journal-title":"Cancer Res"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ajpath.2013.11.007","article-title":"betaIII-tubulin overexpression is an independent predictor of prostate cancer progression tightly linked to ERG fusion status and PTEN deletion","volume":"184","author":"MC Tsourlakis","year":"2014","journal-title":"Am J Pathol"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.gene.2014.03.037","article-title":"Sox9 and Hif-2\u03b1 regulate TUBB3 gene expression and affect ovarian cancer aggressiveness","volume":"542","author":"G Raspaglio","year":"2014","journal-title":"Gene"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/1535-7163.MCT-14-0155","article-title":"Mechanisms of resistance to cabazitaxel","volume":"14","author":"GE Duran","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"ref164","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1158\/1078-0432.CCR-05-2715","article-title":"Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients","volume":"12","author":"G Ferrandina","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2174\/156652411798062368","article-title":"Class III \u03b2-tubulin (TUBB3): more than a biomarker in solid tumors?","volume":"11","author":"M Mariani","year":"2011","journal-title":"Current molecular medicine"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3892\/ijmm.2014.1760","article-title":"Increased periostin expression affects the proliferation, collagen synthesis, migration and invasion of keloid fibroblasts under hypoxic conditions","volume":"34","author":"Z Zhang","year":"2014","journal-title":"Int J Mol Med"},{"key":"ref167","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.bjps.2015.11.006","article-title":"Central regions of keloids are severely ischaemic","volume":"69","author":"R Touchi","year":"2016","journal-title":"Journal of plastic, reconstructive & aesthetic surgery: JPRAS"},{"key":"ref168","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.4081\/dr.2015.5880","article-title":"The Use of Chemotherapeutics for the Treatment of Keloid Scars","volume":"7","author":"CD Jones","year":"2015","journal-title":"Dermatol 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