{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:17:21Z","timestamp":1768432641973,"version":"3.49.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172956","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T18:10:29Z","timestamp":1489515029000},"page":"e0172956","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-2842","authenticated-orcid":false,"given":"Juan Carlos","family":"Ledesma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Gim\u00e9nez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mi\u00f1arro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rodr\u00edguez-Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e003015","DOI":"10.1136\/bmjopen-2013-003015","article-title":"The persistence of adolescent binge drinking into adulthood: findings from a 15-year prospective cohort study","volume":"3","author":"L Degenhardt","year":"2013","journal-title":"BMJ Open"},{"key":"ref2","article-title":"EMCDDA-European Monitoring Centre for Drugs and Drug Addiction, European Drug Report: Trends and Developments","year":"2015"},{"key":"ref3","article-title":"ESTUDES 2013 Informe de la encuesta estatal sobre el uso de drogas en estudiantes de ense\u00f1anzas secundarias. Delegaci\u00f3n el gobierno para el Plan Nacional sobre Drogas"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1530-0277.2010.01385.x","article-title":"Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice","volume":"35","author":"LG Coleman Jr","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.alcohol.2012.12.007","article-title":"Effects of intermittent binge alcohol exposure on long-term motor function in young rats","volume":"47","author":"A Forbes","year":"2013","journal-title":"Alcohol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1460-9568.2006.05298.x","article-title":"Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats","volume":"25","author":"M Pascual","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1744-9081-8-32","article-title":"Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice","volume":"8","author":"A Vidal-Infer","year":"2012","journal-title":"Behav Brain Funct"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0899-3289(97)90009-2","article-title":"Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey","volume":"9","author":"BF Grant","year":"1997","journal-title":"J Subst Abuse"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.15288\/jsa.1997.58.638","article-title":"Age of first use: its reliability and predictive utility","volume":"58","author":"E Labouvie","year":"1997","journal-title":"J Stud Alcohol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1360-0443.2006.01426.x","article-title":"Testing the Gateway Hypothesis","volume":"101","author":"DB Kandel","year":"2006","journal-title":"Addiction"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/apa.12851","article-title":"The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives","volume":"104","author":"D Kandel","year":"2015","journal-title":"Acta Paediatr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.phrs.2009.03.006","article-title":"Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids","volume":"60","author":"N Realini","year":"2009","journal-title":"Pharmacol Res"},{"key":"ref13","first-page":"121","article-title":"Cocaine abuse or dependency and other pyschiatric disorders. Madrid study on dual pathology","volume":"6","author":"F Arias","year":"2013","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"ref14","first-page":"122","article-title":"Abuse or dependence on cannabis and other psychiatric disorders. Madrid study on dual pathology prevalence","volume":"41","author":"F Arias","year":"2013","journal-title":"Actas Esp Psiquiatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.289.4.427","article-title":"Escalation of drug use in early-onset cannabis users vs co-twin controls","volume":"289","author":"MT Lynskey","year":"2003","journal-title":"JAMA"},{"issue":"Pt B","key":"ref16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuropharm.2013.07.014","article-title":"Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control","volume":"76","author":"V Deroche-Gamonet","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2015.01.021","article-title":"Dorsal raphe 5-HT<sub>2c<\/sub> receptor and GABA networks regulate anxiety produced by cocaine withdrawal","volume":"93","author":"CP Craige","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00213-005-0107-3","article-title":"Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin","volume":"182","author":"JW Dalley","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuropharm.2007.10.007","article-title":"Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat","volume":"54","author":"SA Perrine","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/15504263.2014.906133","article-title":"Cocaine-induced psychotic disorders: presentation, mechanism, and management","volume":"10","author":"Y Tang","year":"2014","journal-title":"J Dual Diagn"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1460-9568.2004.03274.x","article-title":"Cocaine-experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesions","volume":"19","author":"G Schoenbaum","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ntt.2011.07.011","article-title":"Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice","volume":"34","author":"C Roger-S\u00e1nchez","year":"2012","journal-title":"Neurotoxicol Teratol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00213-011-2329-x","article-title":"Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice","volume":"218","author":"M Rodr\u00edguez-Arias","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e43535","DOI":"10.1371\/journal.pone.0043535","article-title":"Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex","volume":"7","author":"CE Hage","year":"2012","journal-title":"Plos One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e78317","DOI":"10.1371\/journal.pone.0078317","article-title":"Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence","volume":"8","author":"MC Valzachi","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1590\/1516-4446-2013-1139","article-title":"Animal models of anxiety disorders and stress","volume":"35","author":"AC Campos","year":"2013","journal-title":"Rev Bras Psiquiatr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00441-013-1599-5","article-title":"Translational value of startle modulations","volume":"354","author":"M Fendt","year":"2013","journal-title":"Cell Tissue Res"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1590\/1516-4446-2013-1164","article-title":"Animal models for predicting the efficacy and side effects of antipsychotic drugs","volume":"35","author":"PH Gobira","year":"2013","journal-title":"Rev Bras Psiquiatr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/7854_2011_195","article-title":"Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders","volume":"12","author":"SB Powell","year":"2012","journal-title":"Curr Top Behav Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/sj.mp.4001159","article-title":"Mouse genetic models for prepulse inhibition: an early review","volume":"7","author":"MA Geyer","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neubiorev.2009.02.001","article-title":"Top-down modulation of prepulse inhibition of the startle reflex in humans and rats","volume":"33","author":"L Li","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/schbul\/sbp132","article-title":"Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects","volume":"36","author":"M van den Buuse","year":"2010","journal-title":"Schizophr Bull"},{"key":"ref33","first-page":"e3446","article-title":"Habituation and prepulse inhibition of acoustic startle in rodents","author":"B Valsamis","year":"2011","journal-title":"J Vis Exp"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/07853891003769957","article-title":"Rodent models in depression research: Classical strategies and new directions","volume":"42","author":"DD Pollak","year":"2010","journal-title":"Ann Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"JF Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S1734-1140(13)71514-7","article-title":"Preclinical studies on comorbidity between depression and psychostimulant addiction","volume":"65","author":"M Filip","year":"2013","journal-title":"Pharmacol Rep"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s002130050475","article-title":"Individual differences in response to imipramine in the mouse tail suspension test","volume":"134","author":"JM Vaugeois","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31","author":"A Ennaceur","year":"1988","journal-title":"Behav Brain Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1073\/pnas.0406344101","article-title":"Spatial memory, recognition memory, and the hippocampus","volume":"101","author":"NJ Broadbent","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2014.11.015","article-title":"TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment","volume":"45","author":"J Montesinos","year":"2015","journal-title":"Brain Behav Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0149-7634(03)00006-X","article-title":"Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence","volume":"27","author":"G Laviola","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e92576","DOI":"10.1371\/journal.pone.0092576","article-title":"The novelty-seeking phenotype modulates the long-lasting effects of intermittent ethanol administration during adolescence","volume":"9","author":"S Montagud-Romero","year":"2014","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuropharm.2013.08.039","article-title":"Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB\/c mice","volume":"81","author":"FF Sweeney","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1523\/JNEUROSCI.2391-06.2006","article-title":"Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence","volume":"26","author":"YD Black","year":"2006","journal-title":"J Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00213-014-3642-y","article-title":"Higher sensitivity to the conditioned rewarding effects of cocaine and MDMA in High-Novelty-Seekers mice exposed to a cocaine binge during adolescence","volume":"232","author":"A Mateos-Garc\u00eda","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/ejn.13348","article-title":"Cocaine abstinence induces emotional impairment and brain region-specific upregulation of the oxytocin receptor binding","volume":"44","author":"P Georgiou","year":"2016","journal-title":"Eur J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.ps.38.020187.000333","article-title":"New desings in analysis of variance","volume":"38","author":"RR Wilcox","year":"1987","journal-title":"Annu Rev Psychol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00213-003-1427-9","article-title":"Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats","volume":"167","author":"MD Escarabajal","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00213-012-2831-9","article-title":"Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H\u2082O\u2082 scavenger alpha lipoic acid","volume":"226","author":"JC Ledesma","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1038\/npp.2009.125","article-title":"Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition","volume":"34","author":"C Sanchis-Segura","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fnins.2016.00222","article-title":"Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology","volume":"10","author":"EJ Kyzar","year":"2016","journal-title":"Front Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.nbd.2015.03.019","article-title":"Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood","volume":"82","author":"SC Pandey","year":"2015","journal-title":"Neurobiol Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.neuroscience.2013.09.031","article-title":"Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis","volume":"254","author":"TL Briones","year":"2013","journal-title":"Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S1734-1140(13)71530-5","article-title":"Ethanol withdrawal-induced depressive symptoms in animals and therapeutic potential of sigma1 receptor ligands","volume":"65","author":"G Skuza","year":"2013","journal-title":"Pharmacol Rep"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.alcohol.2012.08.001","article-title":"Acute and chronic ethanol intake: effects on spatial and non-spatial memory in rats","volume":"46","author":"LM Garc\u00eda-Moreno","year":"2012","journal-title":"Alcohol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbi.2015.12.006","article-title":"Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence","volume":"53","author":"J Montesinos","year":"2016","journal-title":"Brain Behav Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3922\/j.psns.2009.1.11","article-title":"Intermittent ethanol binge exposure impairs object recognition but spares contextual and tone fear memory in adolescent rats","volume":"2","author":"NT Schaaffhausen","year":"2009","journal-title":"Psychol Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2008.06.004","article-title":"Impaired object recognition following prolonged withdrawal from extended-access cocaine self-administration","volume":"155","author":"LA Briand","year":"2008","journal-title":"Neuroscience"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1017\/S1461145714000625","article-title":"CRF\u2082 receptor-deficiency reduces recognition memory deficits and vulnerability to stress induced by cocaine withdrawal","volume":"17","author":"N Morisot","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"issue":"277","key":"ref60","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuroscience.2014.07.008","article-title":"Long-term effects of chronic cocaine exposure throughout adolescence on anxiety and stress responsivity in a Wistar rat model","volume":"26","author":"CJ Alves","year":"2014","journal-title":"Neuroscience"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2012.01.056","article-title":"Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol","volume":"231","author":"C de Oliveira Cit\u00f3 Mdo","year":"2012","journal-title":"Behav Brain Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e43535","DOI":"10.1371\/journal.pone.0043535","article-title":"Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex","volume":"7","author":"C El Hage","year":"2012","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2010.03.011","article-title":"Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats","volume":"474","author":"BJ Hall","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2011.07.022","article-title":"Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal","volume":"204","author":"DA Kupferschmidt","year":"2012","journal-title":"Neuroscience"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0091-3057(01)00478-6","article-title":"Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats","volume":"68","author":"JU Adams","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s002130050887","article-title":"Effects of sustained cocaine exposure on sensorimotor gating of startle in rats","volume":"142","author":"ZA Martinez","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s002130100759","article-title":"Effects of psychostimulant withdrawal on latent inhibition of conditioned active avoidance and prepulse inhibition of the acoustic startle response","volume":"156","author":"CA Murphy","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2011.06.014","article-title":"Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats","volume":"62","author":"E Chartoff","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/jnc.12753","article-title":"Induction of depressive-like effects by subchronic exposure to cocaine or heroin in laboratory rats","volume":"130","author":"N Zilkha","year":"2014","journal-title":"J Neurochem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.brat.2008.03.010","article-title":"Anxiety sensitivity: a unique predictor of dropout among inner-city heroin and crack\/cocaine users in residential substance use treatment","volume":"46","author":"CW Lejuez","year":"2008","journal-title":"Behav Res Ther"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/acer.13072","article-title":"Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies","volume":"40","author":"M Guizzetti","year":"2016","journal-title":"Alcohol Clin Exp Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:11:43Z","timestamp":1588972303000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172956"}},"subtitle":[],"editor":[{"given":"Yael","family":"Abreu-Villa\u00e7a","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":71,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172956","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]}}}