{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:50:24Z","timestamp":1790214624476,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0172995","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T14:17:06Z","timestamp":1489587426000},"page":"e0172995","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":108,"title":["Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy"],"prefix":"10.1371","volume":"12","author":[{"given":"Ulrike","family":"Esslinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Korniat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Proust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kararigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"M\u00fcller-Nurasyid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Empana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Perret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Bick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kriebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Tiret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan P.","family":"O'Regan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Marguiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boutouyrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lacolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jouven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakon","family":"Hakonarson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Isnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Arbustini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Grallert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Regitz-Zagrosek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Cappola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cambien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Villard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","article-title":"Dilated cardiomyopathy: the complexity of a diverse genetic architecture","volume":"10","author":"RE Hershberger","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"EM McNally","year":"2013","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/eurheartj\/ehr105","article-title":"A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy","volume":"32","author":"E Villard","year":"2011","journal-title":"Eur Heart J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/CIRCGENETICS.109.898395","article-title":"Common variants in HSPB7 and FRMD4B associated with advanced heart failure","volume":"3","author":"TP Cappola","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1073\/pnas.1017494108","article-title":"Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation","volume":"108","author":"TP Cappola","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"CC Chang","year":"2015","journal-title":"GigaScience"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-62703-447-0_9","article-title":"Genome wide complex trait analysis (GCTA): methods, data analyses, and interpretations","volume":"1019","author":"J Yang","year":"2013","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ajhg.2013.04.015","article-title":"Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants","volume":"92","author":"I Ionita-Laza","year":"2013","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000529","article-title":"A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies","volume":"5","author":"BN Howie","year":"2009","journal-title":"PLoS Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"M Kircher","year":"2014","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"GTEx Consortium","year":"2013","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng815","article-title":"Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy","volume":"30","author":"B Gerull","year":"2002","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yjmcc.2007.11.008","article-title":"Lamin A\/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease","volume":"44","author":"CM Wolf","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0300985811402841","article-title":"Cardiomyopathy in \u03b1-kinase 3 (ALPK3)-deficient mice","volume":"49","author":"I Van Sligtenhorst","year":"2012","journal-title":"Vet Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/hmg\/ddq398","article-title":"HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones","volume":"19","author":"MJ Vos","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ana.21553","article-title":"Mutation in BAG3 causes severe dominant childhood muscular dystrophy","volume":"65","author":"D Selcen","year":"2009","journal-title":"Ann Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10534-012-9526-x","article-title":"Physiologic implications of metal-ion transport by ZIP14 and ZIP8","volume":"25","author":"S Jenkitkasemwong","year":"2012","journal-title":"Biometals Int J Role Met Ions Biol Biochem Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/15376516.2012.735277","article-title":"The role of zinc in the prevention of diabetic cardiomyopathy and nephropathy","volume":"23","author":"B Li","year":"2013","journal-title":"Toxicol Mech Methods"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"19702","DOI":"10.1074\/jbc.M110.165548","article-title":"Identification of a novel muscle A-type lamin-interacting protein (MLIP)","volume":"286","author":"E Ahmady","year":"2011","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00047.2005","article-title":"Nuclear lamins: laminopathies and their role in premature ageing","volume":"86","author":"JLV Broers","year":"2006","journal-title":"Physiol Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1161\/CIRCRESAHA.111.259663","article-title":"CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy","volume":"110","author":"Z-P Huang","year":"2012","journal-title":"Circ Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1172\/JCI82423","article-title":"Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis","volume":"125","author":"Z-P Huang","year":"2015","journal-title":"J Clin Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1038\/ncomms6326","article-title":"Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy","volume":"5","author":"R Vald\u00e9s-Mas","year":"2014","journal-title":"Nat Commun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/auto.22921","article-title":"Impairment of protein degradation in myofibrillar myopathy caused by FLNC\/filamin C mutations","volume":"9","author":"RA Kley","year":"2013","journal-title":"Autophagy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.nmd.2010.12.007","article-title":"Myofibrillar myopathies","volume":"21","author":"D Selcen","year":"2011","journal-title":"Neuromuscul Disord NMD"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cub.2009.11.022","article-title":"Chaperone-assisted selective autophagy is essential for muscle maintenance","volume":"20","author":"V Arndt","year":"2010","journal-title":"Curr Biol CB"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1242\/jcs.179887","article-title":"HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles","volume":"129","author":"L-Y Juo","year":"2016","journal-title":"J Cell Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1242\/bio.20121370","article-title":"Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis","volume":"1","author":"M Kan-O","year":"2012","journal-title":"Biol Open"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.201005060","article-title":"Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance","volume":"191","author":"T Iskratsch","year":"2010","journal-title":"J Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0092-8674(04)00210-7","article-title":"Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture","volume":"116","author":"Y Xu","year":"2004","journal-title":"Cell"},{"key":"ref31","first-page":"2990","article-title":"Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor","volume":"77","author":"T Arimura","year":"2013","journal-title":"Circ J Off J Jpn Circ Soc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"35978","DOI":"10.1074\/jbc.M100485200","article-title":"A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes","volume":"276","author":"T Hosoda","year":"2001","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"23639","DOI":"10.1074\/jbc.M110.101063","article-title":"Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells","volume":"285","author":"M Snyder","year":"2010","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jacc.2015.10.093","article-title":"Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy","volume":"67","author":"R Almomani","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/CIRCGENETICS.109.912345","article-title":"Coding Sequence Rare Variants Identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 From 312 Patients With Familial or Idiopathic Dilated Cardiomyopathy","volume":"3","author":"RE Hershberger","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1126\/science.1223602","article-title":"Molecular mechanics of cardiac myosin-binding protein C in native thick filaments","volume":"337","author":"MJ Previs","year":"2012","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00395-011-0235-3","article-title":"Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy","volume":"107","author":"S Schlossarek","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-0169(200002)45:2<149::AID-CM6>3.0.CO;2-G","article-title":"Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin\/ABP-L in sarcomeric Z-disc formation","volume":"45","author":"PF van der Ven","year":"2000","journal-title":"Cell Motil Cytoskeleton"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1126\/science.1110463","article-title":"The kinase domain of titin controls muscle gene expression and protein turnover","volume":"308","author":"S Lange","year":"2005","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ydbio.2011.10.008","article-title":"Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro","volume":"361","author":"M Fujita","year":"2012","journal-title":"Dev Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/15548627.2015.1017186","article-title":"Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle","volume":"11","author":"A Ulbricht","year":"2015","journal-title":"Autophagy"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0229472","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0172995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T06:25:51Z","timestamp":1540275951000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0172995"}},"subtitle":[],"editor":[{"given":"Amanda Ewart","family":"Toland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0172995","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0229472","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}