{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:30:15Z","timestamp":1791689415913,"version":"4.3.4"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0628.13"],"award-info":[{"award-number":["G.0628.13"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["12N0715"],"award-info":[{"award-number":["12N0715"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0173329","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T13:39:46Z","timestamp":1489066786000},"page":"e0173329","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["The role of platelet and endothelial GARP in thrombosis and hemostasis"],"prefix":"10.1371","volume":"12","author":[{"given":"Elien","family":"Vermeersch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Denorme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon F.","family":"De Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vanhoorelbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan M.","family":"Shevach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Unutmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodaka","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Deckmyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tersteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1182\/blood-2006-07-036269","article-title":"Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins","volume":"109","author":"IC Macaulay","year":"2007","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1182\/blood-2008-06-162958","article-title":"A HaemAtlas: characterizing gene expression in differentiated human blood cells","volume":"113","author":"N a Watkins","year":"2009","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1182\/blood-2008-06-162693","article-title":"Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins","volume":"113","author":"MN O\u2019Connor","year":"2009","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00302877","article-title":"New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions","volume":"2","author":"V Ollendorff","year":"1992","journal-title":"Mamm Genome"},{"key":"ref5","first-page":"545","article-title":"Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein","volume":"40","author":"R Roubin","year":"1996","journal-title":"Int J Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13445","DOI":"10.1073\/pnas.0901944106","article-title":"GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells","volume":"106","author":"DQ Tran","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e2705","DOI":"10.1371\/journal.pone.0002705","article-title":"Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression","volume":"3","author":"R Wang","year":"2008","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1002\/eji.200939684","article-title":"Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg","volume":"39","author":"J Stockis","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cancergen.2013.06.002","article-title":"Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13","volume":"206","author":"A Kehrmann","year":"2013","journal-title":"Cancer Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.4049\/jimmunol.1500139","article-title":"Hepatic Stellate Cells Inhibit T Cells through Active TGF- 1 from a Cell Surface-Bound Latent TGF- 1\/GARP Complex","volume":"195","author":"Y Li","year":"2015","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"284ra56","DOI":"10.1126\/scitranslmed.aaa1983","article-title":"Monoclonal antibodies against GARP\/TGF- 1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo","volume":"7","author":"J Cuende","year":"2015","journal-title":"Sci Transl Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1182\/blood-2006-04-020362","article-title":"Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo","volume":"109","author":"R Tiedt","year":"2007","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo","volume":"230","author":"YY Kisanuki","year":"2001","journal-title":"Dev Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.4049\/jimmunol.1300199","article-title":"Regulation of the expression of GARP\/latent TGF-\u03b21 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation","volume":"190","author":"JP Edwards","year":"2013","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1182\/blood-2013-10-534024","article-title":". Vessel wall BAMBI contributes to hemostasis and thrombus stability","volume":"123","author":"II Salles-Crawley","year":"2014","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/ATVBAHA.110.210252","article-title":"Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol","volume":"31","author":"SJA Korporaal","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jth.12765","article-title":"Hematopoietic \u03b17 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis","volume":"13","author":"S Kooijman","year":"2015","journal-title":"J Thromb Haemost"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e115306","DOI":"10.1371\/journal.pone.0115306","article-title":"Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis","volume":"9","author":"S Hofmann","year":"2014","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1161\/CIRCRESAHA.114.302361","article-title":"FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils","volume":"114","author":"C Tersteeg","year":"2014","journal-title":"Circ Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1182\/blood-2015-03-632901","article-title":"Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice","volume":"126","author":"S Verhenne","year":"2015","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/ATVBAHA.108.168369","article-title":"Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease","volume":"28","author":"SF De Meyer","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2040-7378-3-9","article-title":"Platelet glycoprotein Ib\u03b1 is an important mediator of ischemic stroke in mice","volume":"3","author":"SF De Meyer","year":"2011","journal-title":"Exp Transl Stroke Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1160\/TH16-01-0036","article-title":"The VWF-GPIb axis in ischaemic stroke: lessons from animal models","volume":"116","author":"F Denorme","year":"2016","journal-title":"Thromb Haemost"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1111\/j.1538-7836.2009.03606.x","article-title":"Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo","volume":"7","author":"TJ Stalker","year":"2009","journal-title":"J Thromb Haemost"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1182\/blood-2011-10-381715","article-title":"Model systems of genetically modified platelets","volume":"119","author":"T Thijs","year":"2012","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MOH.0000000000000075","article-title":"Zebrafish as a model system for the study of hemostasis and thrombosis","volume":"21","author":"AC Weyand","year":"2014","journal-title":"Curr Opin Hematol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1538-7836.2010.03815.x","article-title":"Hemostasis in Danio rerio: is the zebrafish a useful model for platelet research?","volume":"8","author":"MR Lang","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1172\/JCI1617","article-title":"Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease","volume":"101","author":"Q Wu","year":"1998","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1091\/mbc.E11-12-1018","article-title":"Springer T a. GARP regulates the bioavailability and activation of TGF\u03b2","volume":"23","author":"R Wang","year":"2012","journal-title":"Mol Biol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e0153290","DOI":"10.1371\/journal.pone.0153290","article-title":"How Soluble GARP Enhances TGF\u03b2 Activation. Unutmaz D, editor","volume":"11","author":"S Fridrich","year":"2016","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nm0995-932","article-title":"Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin","volume":"1","author":"DJ Grainger","year":"1995","journal-title":"Nat Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1182\/blood-2011-09-377648","article-title":"Platelet TGF-\u03b21 contributions to plasma TGF-\u03b21, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload","volume":"119","author":"A Meyer","year":"2012","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis","volume":"20","author":"M Labelle","year":"2011","journal-title":"Cancer Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09537100600800743","article-title":"Platelets possess functional TGF-beta receptors and Smad2 protein","volume":"18","author":"PR Lev","year":"2007","journal-title":"Platelets"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1006\/cyto.1996.0182","article-title":"Cytokine mRNA expression in human platelets and a megakaryocytic cell line and cytokine modulation of platelet function","volume":"9","author":"G Soslau","year":"1997","journal-title":"Cytokine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0173329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:25:41Z","timestamp":1540344341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0173329"}},"subtitle":[],"editor":[{"given":"Ingo","family":"Ahrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0173329","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,9]]}}}