{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:37:47Z","timestamp":1790653067412,"version":"4.1.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1 Z1A AI00931"],"award-info":[{"award-number":["1 Z1A AI00931"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0173528","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T14:05:46Z","timestamp":1489068346000},"page":"e0173528","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages"],"prefix":"10.1371","volume":"12","author":[{"given":"Diane C.","family":"Cockrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie M.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly J.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tregei","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Beare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-4619","authenticated-orcid":true,"given":"Robert A.","family":"Heinzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"issue":"3\u20134","key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.vetmic.2009.07.016","article-title":"Q Fever","volume":"140","author":"E Angelakis","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/MMBR.25.3.285-293.1961","article-title":"Airborne Q fever","volume":"25","author":"WD Tigertt","year":"1961","journal-title":"Bacteriol Rev"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/IAI.00406-10","article-title":"<italic>Coxiella burnetii<\/italic> phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages","volume":"78","author":"D Howe","year":"2010","journal-title":"Infect Immun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2217\/fmb-2016-0044","article-title":"Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions","volume":"11","author":"CL Larson","year":"2016","journal-title":"Future microbiology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2014.10.015","article-title":"The macrophage paradox","volume":"41","author":"JV Price","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/cmi.12573","article-title":"Macrophage cell death in microbial infections","volume":"18","author":"SH Chow","year":"2016","journal-title":"Cell Microbiol"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.4049\/jimmunol.177.8.4945","article-title":"Autophagy: eating for good health","volume":"177","author":"MS Swanson","year":"2006","journal-title":"J Immunol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1462-5822.2006.00838.x","article-title":"The autophagic pathway is actively modulated by phase II <italic>Coxiella burnetii<\/italic> to efficiently replicate in the host cell","volume":"9","author":"PS Romano","year":"2007","journal-title":"Cell Microbiol"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1128\/IAI.01236-13","article-title":"<italic>Coxiella burnetii<\/italic> type IV secretion-dependent recruitment of macrophage autophagosomes","volume":"82","author":"CG Winchell","year":"2014","journal-title":"Infect Immun"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"e1004286","DOI":"10.1371\/journal.ppat.1004286","article-title":"A screen of Coxiella burnetii mutants reveals important roles for Dot\/Icm effectors and host autophagy in vacuole biogenesis","volume":"10","author":"HJ Newton","year":"2014","journal-title":"PLoS pathogens"},{"issue":"23","key":"ref11","doi-asserted-by":"crossref","first-page":"E3260","DOI":"10.1073\/pnas.1522811113","article-title":"<italic>Coxiella burnetii<\/italic> effector CvpB modulates phosphoinositide metabolism for optimal vacuole development","volume":"113","author":"E Martinez","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"44","key":"ref12","doi-asserted-by":"crossref","first-page":"18997","DOI":"10.1073\/pnas.1004380107","article-title":"Inhibition of pathogen-induced apoptosis by a <italic>Coxiella burnetii<\/italic> type IV effector protein","volume":"107","author":"A Luhrmann","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/cmi.12066","article-title":"The <italic>Coxiella burnetii<\/italic> type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level","volume":"15","author":"L Klingenbeck","year":"2013","journal-title":"Cell Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1038\/ncomms10205","article-title":"Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA","volume":"6","author":"LD Cunha","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrmicro2295","article-title":"Bacterial manipulation of innate immunity to promote infection","volume":"8","author":"L Diacovich","year":"2010","journal-title":"Nat Rev Microbiol"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"e0145342","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 Macrophages","volume":"10","author":"KA Jablonski","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"M Benoit","year":"2008","journal-title":"J Immunol"},{"issue":"24","key":"ref18","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1073\/pnas.0501863102","article-title":"Virulent <italic>Coxiella burnetii<\/italic> does not activate human dendritic cells: role of lipopolysaccharide as a shielding molecule","volume":"102","author":"JG Shannon","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1196\/annals.1355.024","article-title":"Lack of dendritic cell maturation following infection by <italic>Coxiella burnetii<\/italic> synthesizing different lipopolysaccharide chemotypes","volume":"1063","author":"JG Shannon","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/IAI.48.2.359-365.1985","article-title":"Lipopolysaccharide variation in <italic>Coxiella burnetii<\/italic>: intrastrain heterogeneity in structure and antigenicity","volume":"48","author":"T Hackstadt","year":"1985","journal-title":"Infect Immun"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1128\/JB.188.7.2309-2324.2006","article-title":"Genetic diversity of the Q fever agent, <italic>Coxiella burnetii<\/italic>, assessed by microarray-based whole-genome comparisons","volume":"188","author":"PA Beare","year":"2006","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0008-6215(96)87610-5","article-title":"Structural study on a lipopolysaccharide from <italic>Coxiella burnetii<\/italic> strain Nine Mile in avirulent phase II","volume":"283","author":"R Toman","year":"1996","journal-title":"Carbohydr Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-94-007-4315-1_8","article-title":"The <italic>Coxiella burnetii<\/italic> parasitophorous vacuole","volume":"984","author":"E Ghigo","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1128\/IAI.56.4.802-807.1988","article-title":"Steric hindrance of antibody binding to surface proteins of <italic>Coxiella burnetti<\/italic> by phase I lipopolysaccharide","volume":"56","author":"T Hackstadt","year":"1988","journal-title":"Infect Immun"},{"issue":"52","key":"ref25","doi-asserted-by":"crossref","first-page":"54405","DOI":"10.1074\/jbc.M410340200","article-title":"Stimulation of toll-like receptor 2 by <italic>Coxiella burnetii<\/italic> is required for macrophage production of pro-inflammatory cytokines and resistance to infection","volume":"279","author":"DS Zamboni","year":"2004","journal-title":"J Biol Chem"},{"issue":"1\u20133","key":"ref26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12026-008-8059-4","article-title":"Adaptive immunity to the obligate intracellular pathogen <italic>Coxiella burnetii<\/italic>","volume":"43","author":"JG Shannon","year":"2009","journal-title":"Immunol Res"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1128\/IAI.01536-15","article-title":"Primary role for Toll-like receptor-driven tumor necrosis factor rather than cytosolic immune detection in restricting <italic>Coxiella burnetii<\/italic> phase II replication within mouse macrophages","volume":"84","author":"WP Bradley","year":"2016","journal-title":"Infect Immun"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/cmi.12096","article-title":"Virulent <italic>Coxiella burnetii<\/italic> pathotypes productively infect primary human alveolar macrophages","volume":"15","author":"JG Graham","year":"2013","journal-title":"Cell Microbiol"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1128\/IAI.73.8.4494-4504.2005","article-title":"Specificity of <italic>Legionella pneumophila<\/italic> and <italic>Coxiella burnetii<\/italic> vacuoles and versatility of <italic>Legionella pneumophila<\/italic> revealed by coinfection","volume":"73","author":"JD Sauer","year":"2005","journal-title":"Infect Immun"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/IAI.72.4.2395-2399.2004","article-title":"Genetic control of natural resistance of mouse macrophages to <italic>Coxiella burnetii<\/italic> Infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation","volume":"72","author":"DS Zamboni","year":"2004","journal-title":"Infect Immun"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1128\/IAI.72.4.2075-2080.2004","article-title":"Phagocytosis of apoptotic cells increases the susceptibility of macrophages to infection with <italic>Coxiella burnetii<\/italic> Phase II through down-modulation of nitric oxide production","volume":"72","author":"DS Zamboni","year":"2004","journal-title":"Infect Immun"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1128\/IAI.71.3.1225-1233.2003","article-title":"Nitric oxide partially controls <italic>Coxiella burnetii<\/italic> phase II infection in mouse primary macrophages","volume":"71","author":"DS Zamboni","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.chom.2012.10.015","article-title":"Impaired stimulation of p38alpha-MAPK\/Vps41-HOPS by LPS from pathogenic <italic>Coxiella burnetii<\/italic> prevents trafficking to microbicidal phagolysosomes","volume":"12","author":"AO Barry","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1128\/IAI.00411-16","article-title":"Murine alveolar macrophages are highly susceptible to replication of <italic>Coxiella burnetii<\/italic> phase II in vitro","volume":"84","author":"TD Fernandes","year":"2016","journal-title":"Infect Immun"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"e54566","DOI":"10.1371\/journal.pone.0054566","article-title":"Effector protein translocation by the Coxiella burnetii Dot\/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole","volume":"8","author":"HJ Newton","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1128\/IAI.00901-07","article-title":"Attenuated <italic>Coxiella burnetii<\/italic> phase II causes a febrile response in gamma interferon knockout and Toll-like receptor 2 knockout mice and protects against reinfection","volume":"75","author":"J Ochoa-Reparaz","year":"2007","journal-title":"Infect Immun"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1128\/IAI.70.9.5140-5147.2002","article-title":"Nitric oxide inhibits <italic>Coxiella burnetii<\/italic> replication and parasitophorous vacuole maturation","volume":"70","author":"D Howe","year":"2002","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1128\/AEM.02826-10","article-title":"Isolation from animal tissue and genetic transformation of <italic>Coxiella burnetii<\/italic> are facilitated by an improved axenic growth medium","volume":"77","author":"A Omsland","year":"2011","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1128\/IAI.00033-15","article-title":"Replication of <italic>Salmonella enterica<\/italic> serovar Typhimurium in human monocyte-derived macrophages","volume":"83","author":"SK Lathrop","year":"2015","journal-title":"Infect Immun"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1128\/CVI.00319-13","article-title":"Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor alpha","volume":"20","author":"DD Crane","year":"2013","journal-title":"Clin Vaccine Immunol"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1128\/IAI.64.8.2923-2929.1996","article-title":"The <italic>Bcg\/Ity\/Lsh<\/italic> locus: genetic transfer of resistance to infections in C57BL\/6J mice transgenic for the <italic>Nramp1 Gly169<\/italic> allele","volume":"64","author":"G Govoni","year":"1996","journal-title":"Infect Immun"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nmeth865","article-title":"Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8","volume":"3","author":"GG Wang","year":"2006","journal-title":"Nat Methods"},{"issue":"21","key":"ref43","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JB.186.21.7344-7352.2004","article-title":"Temporal analysis of <italic>Coxiella burnetii<\/italic> morphological differentiation","volume":"186","author":"SA Coleman","year":"2004","journal-title":"J Bacteriol"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"PJ Murray","year":"2014","journal-title":"Immunity"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1538\/expanim.58.141","article-title":"Genetic differences among C57BL\/6 substrains","volume":"58","author":"K Mekada","year":"2009","journal-title":"Exp Anim"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/eji.201040962","article-title":"Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells","volume":"41","author":"M Rosas","year":"2011","journal-title":"Eur J Immunol"},{"issue":"31","key":"ref47","doi-asserted-by":"crossref","first-page":"18984","DOI":"10.1074\/jbc.R115.643973","article-title":"Nramp1 and other transporters involved in metal withholding during Infection","volume":"290","author":"M Wessling-Resnick","year":"2015","journal-title":"J Biol Chem"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1189\/jlb.0206079","article-title":"Macrophage nutriprive antimicrobial mechanisms","volume":"79","author":"R Appelberg","year":"2006","journal-title":"J Leukoc Biol"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0966-842X(01)02098-4","article-title":"Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions","volume":"9","author":"JR Forbes","year":"2001","journal-title":"Trends Microbiol"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.182.3.655","article-title":"The <italic>Ity\/Lsh\/Bcg<\/italic> locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene","volume":"182","author":"S Vidal","year":"1995","journal-title":"J Exp Med"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"e111763","DOI":"10.1371\/journal.pone.0111763","article-title":"Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background","volume":"9","author":"WP Loomis","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0300985813478213","article-title":"<italic>Salmonella enterica<\/italic> causes more severe inflammatory disease in C57\/BL6 <italic>Nramp1G169<\/italic> mice than Sv129S6 mice","volume":"50","author":"DE Brown","year":"2013","journal-title":"Vet Pathol"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"e00175","DOI":"10.1128\/mBio.00175-11","article-title":"Dot\/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages","volume":"2","author":"PA Beare","year":"2011","journal-title":"MBio"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1128\/JB.01532-14","article-title":"Essential role for the response regulator PmrA in <italic>Coxiella burnetii<\/italic> type 4B secretion and colonization of mammalian host cells","volume":"196","author":"PA Beare","year":"2014","journal-title":"J Bacteriol"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/IAI.02763-14","article-title":"<italic>Coxiella burnetii<\/italic> effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication","volume":"83","author":"CL Larson","year":"2015","journal-title":"Infect Immun"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1073\/pnas.78.5.3240","article-title":"Biochemical stratagem for obligate parasitism of eukaryotic cells by <italic>Coxiella burnetii<\/italic>","volume":"78","author":"T Hackstadt","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2045-3701-3-30","article-title":"Cell density during differentiation can alter the phenotype of bone marrow-derived macrophages","volume":"3","author":"CM Lee","year":"2013","journal-title":"Cell Biosci"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.134.2.982","article-title":"Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons","volume":"134","author":"MK Warren","year":"1985","journal-title":"J Immunol"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"T Hussell","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"14","key":"ref60","first-page":"1.1","article-title":"The isolation and characterization of muring macrophages","volume":"111","author":"R Goncalves","year":"2015","journal-title":"Curr Protoc Immun"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1128\/IAI.73.4.2469-2477.2005","article-title":"Q fever pneumonia: virulence of <italic>Coxiella burnetii<\/italic> pathovars in a murine model of aerosol infection","volume":"73","author":"A Stein","year":"2005","journal-title":"Infect Immun"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1128\/IAI.67.5.2225-2232.1999","article-title":"Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7","volume":"67","author":"G Govoni","year":"1999","journal-title":"Infect Immun"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/sj.gene.6363912","article-title":"Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome","volume":"4","author":"KJ Helbig","year":"2003","journal-title":"Genes Immun"},{"issue":"Pt 3","key":"ref64","first-page":"691","article-title":"Animal models in Q fever: pathological responses of inbred mice to phase I <italic>Coxiella burnetii<\/italic>","volume":"133","author":"GH Scott","year":"1987","journal-title":"J Gen Microbiol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/IAI.01141-08","article-title":"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus <italic>Coxiella<\/italic>","volume":"77","author":"PA Beare","year":"2009","journal-title":"Infect Immun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1099\/mic.0.046649-0","article-title":"A unique Coxiella burnetii lipoprotein involved in metal binding (LimB)","volume":"157","author":"JM Battisti","year":"2011","journal-title":"Microbiology"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1128\/IAI.01609-07","article-title":"Limited role for iron regulation in <italic>Coxiella burnetii<\/italic> pathogenesis","volume":"76","author":"HL Briggs","year":"2008","journal-title":"Infect Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0173528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:26:54Z","timestamp":1692703614000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0173528"}},"subtitle":[],"editor":[{"given":"James E","family":"Samuel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0173528","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,9]]}}}