{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:17:04Z","timestamp":1793222224976,"version":"4.5.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["5063519"],"award-info":[{"award-number":["5063519"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["5063519"],"award-info":[{"award-number":["5063519"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["5063519"],"award-info":[{"award-number":["5063519"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["5063519"],"award-info":[{"award-number":["5063519"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005432","name":"Pohjois-Savon Rahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005432","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Instrumentarium Science Foundation"},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Aarne Koskelo Foundation"},{"name":"Mauri and Sirkka Wiljasalo Fund"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0173703","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T13:57:05Z","timestamp":1489413425000},"page":"e0173703","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Morphological features of the left atrial appendage in consecutive coronary computed tomography angiography patients with and without atrial fibrillation"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-1772","authenticated-orcid":true,"given":"Miika","family":"Korhonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Parkkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"Hedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Muuronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Onatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Mustonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Vanninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Taina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-0404.2007.00953.x","article-title":"Distribution of etiologies in patients above and below age 45 with first-ever ischemic stroke","volume":"117","author":"G Telman","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","article-title":"Embolic strokes of undetermined source: the case for a new clinical construct","volume":"13","author":"RG Hart","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"DR Holmes","year":"2009","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrcardio.2014.77","article-title":"Cardiac imaging for assessment of left atrial appendage stasis and thrombosis","volume":"11","author":"J Romero","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham Study","volume":"22","author":"PA Wolf","year":"1991","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ijcard.2006.07.162","article-title":"Anatomical remodeling of left atria in subjects with chronic and paroxysmal atrial fibrillation evaluated by multislice computed tomography","volume":"119","author":"M Imada","year":"2007","journal-title":"Int J Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCIMAGING.113.001317","article-title":"Complex left atrial appendage morphology and left atrial appendage thrombus formation in patients with atrial fibrillation","volume":"7","author":"M Yamamoto","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.hrthm.2013.01.036","article-title":"Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores","volume":"10","author":"T Kimura","year":"2013","journal-title":"Heart Rhythm"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jacc.2012.04.032","article-title":"Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study","volume":"60","author":"L Di Biase","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref10","first-page":"1","article-title":"Relationship between body mass index and left atrial appendage thrombus in nonvalvular atrial fibrillation","volume":"141","author":"KP Cohoon","year":"2015","journal-title":"J Thromb Thrombolysis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0894-7317(96)90478-2","article-title":"Influence of left atrial pressure on left atrial appendage flow velocity patterns in patients in sinus rhythm","volume":"9","author":"T Tabata","year":"1996","journal-title":"J Am Soc Echocardiogr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.07-1769","article-title":"Aging dilates atrium and pulmonary veins: implications for the genesis of atrial fibrillation","volume":"133","author":"NH Pan","year":"2008","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1161\/01.CIR.96.9.3112","article-title":"Anatomy of the normal left atrial appendage: a quantitative study of age-related changes in 500 autopsy hearts: implications for echocardiographic examination","volume":"96","author":"JP Veinot","year":"1997","journal-title":"Circulation"},{"issue":"Suppl 2","key":"ref14","doi-asserted-by":"crossref","first-page":"s371","DOI":"10.2337\/dc11-s250","article-title":"Myocardial, perivascular, and epicardial fat","volume":"34","author":"P Iozzo","year":"2011","journal-title":"Diabetes Care"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4330\/wjc.v5.i12.459","article-title":"Radiation dose measurements in coronary CT angiography","volume":"5","author":"A Sabarudin","year":"2013","journal-title":"World J Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1540-8167.2010.01814.x","article-title":"Left atrial appendage studied by computed tomography to help plan for appendage closure device placement","volume":"21","author":"Y Wang","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body surface area","volume":"317","author":"RD Mosteller","year":"1987","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.hrthm.2014.08.016","article-title":"Left atrial appendage morphology and thromboembolic risk after catheter ablation for atrial fibrillation","volume":"11","author":"S Nedios","year":"2014","journal-title":"Heart Rhythm"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.hrthm.2013.09.065","article-title":"Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation","volume":"10","author":"IM Khurram","year":"2013","journal-title":"Heart Rhythm"},{"key":"ref20","first-page":"59","article-title":"Correlation between left atrial appendage morphology and flow velocity in patients with paroxysmal atrial fibrillation","volume":"17","author":"K Fukushima","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e0126818","DOI":"10.1371\/journal.pone.0126818","article-title":"Quantitative Evaluation of the Substantially Variable Morphology and Function of the Left Atrial Appendage and Its Relation with Adjacent Structures","volume":"10","author":"CY Li","year":"2015","journal-title":"PLoS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jcmg.2014.08.009","article-title":"The left atrial appendage: anatomy, function, and noninvasive evaluation","volume":"7","author":"R Beigel","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","article-title":"Heart disease and stroke statistics\u20142016 update: a report from the American Heart Association","volume":"133","author":"D Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s00330-015-3962-2","article-title":"Assessment of normal left atrial appendage anatomy and function over gender and ages by dynamic cardiac CT","volume":"26","author":"S Boucebci","year":"2016","journal-title":"Eur Radiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/clc.4960240107","article-title":"Influence of age on left atrial appendage function in patients with nonvalvular atrial fibrillation","volume":"24","author":"A Ilercil","year":"2001","journal-title":"Clin Cardiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e3260","DOI":"10.1097\/MD.0000000000003260","article-title":"The Abundance of Epicardial Adipose Tissue Surrounding Left Atrium Is Associated With the Occurrence of Stroke in Patients With Atrial Fibrillation","volume":"95","author":"HM Tsao","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0002-9149(82)90274-0","article-title":"Left atrial volume overload in mitral regurgitation: A two dimensional echocardiographic study","volume":"49","author":"LG Gehl","year":"1982","journal-title":"Am J Cardiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ahj.2012.03.017","article-title":"From pressure overload to volume overload: aortic regurgitation after transcatheter aortic valve implantation","volume":"163","author":"M Gotzmann","year":"2012","journal-title":"Am Heart J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1054-8807(00)00030-2","article-title":"Structural remodeling of the left atrial appendage in patients with chronic non-valvular atrial fibrillation: Implications for thrombus formation, systemic embolism, and assessment by transesophageal echocardiography","volume":"9","author":"J Shirani","year":"2000","journal-title":"Cardiovasc Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/hrt.82.5.555","article-title":"Left atrial appendage anatomy and function: short term response to sustained atrial fibrillation","volume":"82","author":"MJ Weigner","year":"1999","journal-title":"Heart"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF03091770","article-title":"Age is an independent risk factor for left atrial dysfunction: results from an observational study","volume":"18","author":"MA Ploumen","year":"2010","journal-title":"Neth Heart J"},{"key":"ref32","first-page":"89","article-title":"Obesity is associated with left atrial enlargement, E\/A reversal and left ventricular hypertrophy","volume":"13","author":"MR Movahed","year":"2008","journal-title":"Exp Clin Cardiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1532-429X-12-65","article-title":"Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance","volume":"12","author":"AM Maceira","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/CIRCIMAGING.108.826602","article-title":"Left atrial volume and geometry in healthy aging: the Cardiovascular Health Study","volume":"2","author":"GP Aurigemma","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1476-7120-12-28","article-title":"Which method of left atrium size quantification is the most accurate to recognize thromboembolic risk in patients with non-valvular atrial fibrillation?","volume":"12","author":"A Faustino","year":"2014","journal-title":"Cardiovasc Ultrasound"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2007.09.026","article-title":"Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation","volume":"51","author":"G Casaclang-Verzosa","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.CIR.82.3.792","article-title":"Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study","volume":"82","author":"AJ Sanfilippo","year":"1990","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/clc.20449","article-title":"Factors to Predict Recurrence of Atrial Fibrillation in Patients with Hypertension","volume":"32","author":"X Ma","year":"2009","journal-title":"Clin Cardiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.41.5.817","article-title":"Quantitative angiography, IV: relationships of left atrial and ventricular pressure and volume in mitral valve disease","volume":"41","author":"JW Kennedy","year":"1970","journal-title":"Circulation"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.amjcard.2004.01.046","article-title":"Left atrium remodeling after acute myocardial infarction (results of the GISSI-3 Echo Substudy)","volume":"93","author":"BA Popescu","year":"2004","journal-title":"Am J Cardiol"},{"key":"ref41","first-page":"191","article-title":"Clinical Implications of Left Atrial Enlargement: A Review","volume":"9","author":"DA Patel","year":"2009","journal-title":"Ochsner J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.109.928903","article-title":"Left atrial appendage: an underrecognized trigger site of atrial fibrillation","volume":"122","author":"L Di Biase","year":"2010","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e79519","DOI":"10.1371\/journal.pone.0079519","article-title":"Left Atrial Appendage Volume Increased in More Than Half of Patients with Cryptogenic Stroke","volume":"8","author":"M Taina","year":"2013","journal-title":"PLoS ONE"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e0118822","DOI":"10.1371\/journal.pone.0118822","article-title":"Left atrial appendage morphology in patients with suspected cardiogenic stroke without known atrial fibrillation","volume":"10","author":"M Korhonen","year":"2015","journal-title":"PLoS ONE"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0173703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T13:33:55Z","timestamp":1568900035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0173703"}},"subtitle":[],"editor":[{"given":"Carmine","family":"Pizzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0173703","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]}}}