{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:53:44Z","timestamp":1790888024443,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0173775","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T14:23:58Z","timestamp":1489587838000},"page":"e0173775","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus)"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-2460","authenticated-orcid":true,"given":"Uwe","family":"Kierdorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl V.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Flohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Kierdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"ref1","article-title":"Handbuch der speziellen pathologischen Anatomie und Histologie","volume":"9","author":"G Herzog","year":"1944"},{"key":"ref2","first-page":"157","article-title":"Tumors in Domestic Animals","author":"RR Pool","year":"1990"},{"key":"ref3","first-page":"3628","article-title":"Diagnosis of Bone and Joint Disorders","volume":"6","author":"D Resnick","year":"1995"},{"key":"ref4","first-page":"633","article-title":"Osteochondromas: Review of the clinical, radiological and pathological features","volume":"22","author":"P Kitsoulis","year":"2008","journal-title":"In Vivo"},{"key":"ref5","article-title":"Dahlin\u2019s Bone Tumors","author":"KK Unni","year":"2010"},{"key":"ref6","article-title":"Dorfman and Czerniak\u2019s Bone Tumors","author":"B Czerniak","year":"2016"},{"key":"ref7","first-page":"16","article-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","volume":"1","author":"LE Craig","year":"2016"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1177\/1040638713495545","article-title":"Occurrence of osteochondromatosis (multiple cartilaginous exostoses) in a domestic pig (<italic>Sus scrofa domesticus<\/italic>)","volume":"25","author":"S de Brot","year":"2013","journal-title":"J Vet Diagn Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2013.11.003","article-title":"Heparan sulfate as a regulator of endochondral ossification and osteochondroma development","volume":"34","author":"K Jochmann","year":"2014","journal-title":"Matrix Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/jcp.55.3.226","article-title":"Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma. A case report of a patient with hereditary multiple exostoses","volume":"55","author":"JVMG Bov\u00e9e","year":"2002","journal-title":"J Clin Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0266-4356(85)90088-9","article-title":"Osteochondroma of the mandibular condyle. Report of a case and review of the literature","volume":"23","author":"H Forssell","year":"1985","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0030-4220(93)90224-R","article-title":"Osteochondroma of the coronoid process of the mandible. Report of a case and review of the literature","volume":"75","author":"A Kerscher","year":"1993","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1055\/s-0034-1387189","article-title":"Solitary osteochondroma of the skull base: a case report and literature review","volume":"76","author":"H Hongo","year":"2015","journal-title":"J Neurol Surg Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0973-029X.140912","article-title":"Osteochondroma of the palate: An interesting and an unusual case presentation","volume":"18","author":"KKR Ealla","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/dvdy.24010","article-title":"Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses","volume":"242","author":"J Huegel","year":"2013","journal-title":"Dev Dyn"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/oxfordjournals.jhered.a110351","article-title":"Hereditary multiple exostosis. A comparative human-equine-epidemiologic study","volume":"78","author":"NC Leone","year":"1987","journal-title":"J Hered"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"AG Knudson","year":"1971","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref18","first-page":"149","article-title":"Osteochondromatosis in a rhesus macaque (<italic>Macaca mulatta<\/italic>)","volume":"62","author":"KA Matthews","year":"2012","journal-title":"Comp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3354\/dao02538","article-title":"Severe soft tissue ossification in a southern right whale <italic>Eubalaena australis<\/italic>","volume":"102","author":"L La Sala","year":"2012","journal-title":"Dis Aquat Organ"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/02724634.1992.10011467","article-title":"Multiple hereditary osteochondroma in Oligocene <italic>Hesperocyon<\/italic> (Carnivora: Canidae)","volume":"12","author":"X Wang","year":"1992","journal-title":"J Vert Paleont"},{"key":"ref21","first-page":"148","article-title":"Ost\u00e9o-chondrome de la nuque chez un chevreuil","volume":"61","author":"M Douville","year":"1907","journal-title":"Bull Soc Gen Med Vet"},{"key":"ref22","first-page":"52","article-title":"Knochengeschwulst an Damhirschstange","volume":"31","author":"H Kierdorf","year":"1985","journal-title":"Z Jagdwiss"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.7589\/0090-3558-25.2.258","article-title":"Cranial osteochondroma in a white-tailed deer (<italic>Odocoileus virginianus<\/italic>)","volume":"25","author":"ES Williams","year":"1989","journal-title":"J Wildl Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/joa.12091","article-title":"The structure of pedicle and hard antler bone in the European roe deer (<italic>Capreolus capreolus<\/italic>): A light microscope and backscattered electron imaging study","volume":"223","author":"U Kierdorf","year":"2013","journal-title":"J Anat"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","article-title":"Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies","volume":"23","author":"P Roschger","year":"1998","journal-title":"Bone"},{"key":"ref26","article-title":"Deer antlers: Regeneration, Function, and Evolution","author":"RJ Goss","year":"1983"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12957-016-0777-9","article-title":"Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle","volume":"14","author":"SM Kim","year":"2016","journal-title":"World J Surg Oncol"},{"key":"ref28","first-page":"715","article-title":"Tumor-like growth of antlers in castrated fallow deer: an electron microscopic study","volume":"4","author":"RJ Goss","year":"1990","journal-title":"Scanning Microsc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ar.1092410302","article-title":"Future directions in antler research","volume":"241","author":"RJ Goss","year":"1995","journal-title":"Anat Rec"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0300985814528216","article-title":"Antleroma in a free-ranging white-tailed deer (<italic>Odocoileus virginianus<\/italic>)","volume":"52","author":"BA Munk","year":"2015","journal-title":"Vet Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1210\/endo-40-3-202","article-title":"The effects of gonadectomy and the administration of testosterone propionate on the growth of antlers in male and female deer","volume":"40","author":"GB Wislocki","year":"1947","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/ar.a.20127","article-title":"Histological structure of antlers in castrated male fallow deer (<italic>Dama dam<\/italic>a)","volume":"281A","author":"U Kierdorf","year":"2004","journal-title":"Anat Rec"},{"key":"ref33","article-title":"Tumors of Bone","author":"CF Geschickter","year":"1949"},{"key":"ref34","first-page":"9","article-title":"Morphobiologische Untersuchungen am Cerviden-Geweih. Werden, Wechsel und Wesen des Rehgeh\u00f6rns","volume":"3","author":"GB Gruber","year":"1937","journal-title":"Nachr Ges Wiss G\u00f6ttingen Math Physik Kl NF Fachgr VI"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF02060300","article-title":"The ossification process of the developing antler in the white-tailed deer (<italic>Odocoileus virginianus<\/italic>)","volume":"14","author":"WJ Banks","year":"1974","journal-title":"Calc Tiss Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0940-9602(11)80085-3","article-title":"A light microscopic study of primary antler development in fallow deer (<italic>Dama dama<\/italic>)","volume":"177","author":"H Kierdorf","year":"1995","journal-title":"Ann Anat"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bone.2012.09.015","article-title":"Labeling studies on cortical bone formation in the antlers of red deer (<italic>Cervus elaphus<\/italic>)","volume":"52","author":"S Gomez","year":"2013","journal-title":"Bone"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/BF02041151","article-title":"\u00dcber den Geweihwechsel der Hirsche, besonders \u00fcber den Knorpel- und Knochenbildungsprozess der Substantia spongiosa der Baststangen","volume":"51","author":"K von Korff","year":"1914","journal-title":"Anat Hefte I Abt"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bone.2011.10.026","article-title":"Does nutrition affect bone porosity and mineral tissue distribution in deer antlers? The relationship between histology, mechanical properties and mineral composition","volume":"50","author":"T Landete-Castillejos","year":"2012","journal-title":"Bone"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000300565","article-title":"Deer antlers\u2013A model of mammalian appendage regeneration: An extensive review","volume":"57","author":"U Kierdorf","year":"2011","journal-title":"Gerontology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0173775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:01:27Z","timestamp":1540339287000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0173775"}},"subtitle":[],"editor":[{"given":"Douglas","family":"Thamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0173775","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}