{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:14:34Z","timestamp":1754194474522,"version":"3.37.3"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL067245"],"award-info":[{"award-number":["R01HL067245"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37HL091102"],"award-info":[{"award-number":["R37HL091102"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL105759"],"award-info":[{"award-number":["R01HL105759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL113647"],"award-info":[{"award-number":["R01HL113647"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL117163"],"award-info":[{"award-number":["R01HL117163"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL085577"],"award-info":[{"award-number":["P01HL085577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL122525"],"award-info":[{"award-number":["R01HL122525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0173963","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T22:31:29Z","timestamp":1490135489000},"page":"e0173963","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["PIM1-minicircle as a therapeutic treatment for myocardial infarction"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-2434","authenticated-orcid":true,"given":"Nan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyan J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Broughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sailay","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Loaiza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicky","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pearl","family":"Quijada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Gude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Sussman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.rec.2013.10.002","article-title":"The Epidemiology of Coronary Heart Disease","volume":"67","author":"I Ferreira-Gonz\u00e1lez","year":"2014","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"year":"2012","key":"ref2","article-title":"Disease statistics"},{"key":"ref3","first-page":"125","article-title":"Heart Disease and Stroke Statistics\u20142012 Update: A Report from the American Heart Association","author":"VL Roger","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrcardio.2012.178","article-title":"Devices in the management of advanced, chronic heart failure","volume":"10","author":"WT Abraham","year":"2012","journal-title":"Nature Reviews Cardiology"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2165\/00129784-200606020-00003","article-title":"Preventing Cardiovascular Disease in the 21st Century","volume":"6","author":"ML Daviglus","year":"2006","journal-title":"American Journal of Cardiovascular Drugs"},{"issue":"9806","key":"ref6","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0140-6736(11)61590-0","article-title":"Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial","volume":"378","author":"R Bolli","year":"2011","journal-title":"The Lancet"},{"key":"ref7","unstructured":"Cardiac stem cell therapies for congenital heart diseases. Stem Cell &amp; Translational Investigation Stem Cell TranslInvestig. 2015."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature05423","article-title":"Potential of stem-cell-based therapies for heart disease","volume":"444","author":"D Srivastava","year":"2006","journal-title":"Nature"},{"issue":"30","key":"ref9","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.2174\/138161211797904181","article-title":"Resident cardiac stem cells","volume":"17","author":"F C.","year":"2011","journal-title":"CPDCurrent Pharmaceutical Design"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","article-title":"Adult cardiac stem cells are multipotent and support myocardial regeneration","volume":"114","author":"AP Beltrami","year":"2003","journal-title":"Cell"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cjca.2014.03.021","article-title":"The rejuvenation of aged stem cells for cardiac repair","volume":"30","author":"A Ludke","year":"2014","journal-title":"Canadian Journal of Cardiology"},{"issue":"7288","key":"ref12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature08982","article-title":"Linking functional decline of telomeres, mitochondria and stem cells during ageing","volume":"464","author":"E Sahin","year":"2010","journal-title":"Nature"},{"issue":"15","key":"ref13","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/eurheartj\/ehs072","article-title":"Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrow-derived progenitor cells and prevents cardiac dysfunction after a myocardial infarction","volume":"34","author":"S-H Li","year":"2012","journal-title":"European Heart Journal"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajpath.2011.03.036","article-title":"Effects of age and heart failure on human cardiac stem cell function","volume":"179","author":"D Cesselli","year":"2011","journal-title":"The American Journal of Pathology"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/CIRCRESAHA.108.175943","article-title":"Aging and disease as modifiers of efficacy of cell therapy","volume":"102","author":"S Dimmeler","year":"2008","journal-title":"Circulation Research"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jtcvs.2009.08.052","article-title":"Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipients","volume":"139","author":"Y Zhuo","year":"2010","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"5","key":"ref17","first-page":"H2089","article-title":"Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy","volume":"289","author":"H Zhang","year":"2005","journal-title":"AJP: Heart and Circulatory Physiology"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/sj.onc.1203355","article-title":"Developmental expression of Pim kinases suggests functions also outside of the hematopoietic system","volume":"19","author":"A Eichmann","year":"2000","journal-title":"Oncogene"},{"issue":"14","key":"ref19","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jacc.2012.04.047","article-title":"Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair","volume":"60","author":"S Mohsin","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2004.11.005","article-title":"The serine\/threonine kinase Pim-1","volume":"37","author":"M Bachmann","year":"2005","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"ref21","article-title":"Pim1 kinase overexpression enhances ckit+ cardiac stem cell cardiac repair following myocardial infarction in swine","author":"S Kulandavelu","year":"2016","journal-title":"Journalof the American College of Cardiology"},{"issue":"21","key":"ref22","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1161\/CIRCULATIONAHA.109.884403","article-title":"Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase","volume":"120","author":"KM Fischer","year":"2009","journal-title":"Circulation"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/nm1671","article-title":"Pim-1 regulates cardiomyocyte survival downstream of Akt","volume":"13","author":"JA Muraski","year":"2007","journal-title":"Nature Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4142\/jvs.2001.2.3.167","article-title":"Pim-1: a serine\/threonine kinase with a role in cell survival, proliferation, differentiation and tumor genesis","volume":"2","author":"Z Wang","year":"2001","journal-title":"Journal of Veterinary Science"},{"issue":"52","key":"ref25","doi-asserted-by":"crossref","first-page":"54742","DOI":"10.1074\/jbc.M409140200","article-title":"Role of Pim-1 in smooth muscle cell proliferation","volume":"279","author":"N Katakami","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"46","key":"ref26","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1073\/pnas.0608138103","article-title":"Gene transfer in humans using a conditionally replicating lentiviral vector","volume":"103","author":"BL Levine","year":"2006","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1089\/scd.2013.0621","article-title":"Vectorology and factor delivery in induced pluripotent stem cell reprogramming","volume":"23","author":"K Hu","year":"2014","journal-title":"Stem Cells and Development"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nri1713","article-title":"Molecular defects in T- and B-cell primary immunodeficiency diseases","volume":"5","author":"P Cunningham-Rundles CPonda","year":"2005","journal-title":"Nature Reviews Immunology"},{"issue":"5644","key":"ref29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1","volume":"302","author":"S Hacein-Bey-Abina","year":"2003","journal-title":"Science"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMra032207","article-title":"Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency","volume":"350","author":"T McCormack MRabbitts","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1525-0016(03)00168-0","article-title":"Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo","volume":"8","author":"Z Chen","year":"2003","journal-title":"Molecular Therapy"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.gt.3300816","article-title":"Minicircle: an improved DNA molecule for in vitro and in vivo gene transfer","volume":"6","author":"A Darquet","year":"1999","journal-title":"Gene Therapy"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nprot.2010.173","article-title":"Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors","volume":"6","author":"K Narsinh","year":"2010","journal-title":"Nature Protocol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/FJC.0b013e318194234e","article-title":"Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor","volume":"53","author":"S Stenler","year":"2009","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.1161\/CIRCULATIONAHA.108.841155","article-title":"Novel minicircle vector for gene therapy in murine myocardial infarction","volume":"120","author":"M Huang","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/hum.1993.4.4-419","article-title":"Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice","volume":"4","author":"M Manthorpe","year":"1993","journal-title":"Human Gene Therapy"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1172\/JCI118750","article-title":"Expression of naked DNA in human, pig, and mouse skin","volume":"97","author":"U Hengge","year":"1996","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1006\/jmcc.1997.0389","article-title":"Direct gene transfer into the mouse heart","volume":"29","author":"K Li","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1089\/hum.1994.5.7-837","article-title":"In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection","volume":"5","author":"M Sikes","year":"1994","journal-title":"Human Gene Therapy"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/hmg\/1.6.363","article-title":"Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle","volume":"1","author":"J Wolff","year":"1992","journal-title":"Human Molecular Genetics"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.20192","article-title":"An uncomfortable silence \u2026 while we all search for a better reporter gene in adult stem cell biology","volume":"39","author":"R Mctaggart","year":"2004","journal-title":"Hepatology"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1634\/stemcells.2007-0241","article-title":"Limitations of green fluorescent protein as a cell lineage marker","volume":"25","author":"E Swenson","year":"2007","journal-title":"Stem Cells"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/A:1004014211408","article-title":"Rapid and sensitive detection of enhanced green fluorescent protein expression in paraffin sections by confocal laser scanning microscopy","volume":"32","author":"I Walter","year":"2000","journal-title":"The Histochemical Journal"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/14760584.5.6.803","article-title":"Optimization and delivery of plasmid DNA for vaccination","volume":"5","author":"W Jechlinger","year":"2006","journal-title":"Expert Review of Vaccines"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0173963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:23:01Z","timestamp":1588987381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0173963"}},"subtitle":[],"editor":[{"given":"Patrick C.H.","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0173963","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}