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Global incidence and prevalence of selected curable sexually transmitted infections. 2008."},{"key":"ref2","unstructured":"National Notifiable Diseases Surveillance System. Number of notifications of Chlamydial infections, Australia, by age group and sex. 2015; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www9.health.gov.au\/cda\/source\/cda-index.cfm\" xlink:type=\"simple\">http:\/\/www9.health.gov.au\/cda\/source\/cda-index.cfm<\/ext-link>. accessed May 2016."},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2334-12-113","article-title":"The prevalence of Chlamydia trachomatis infection in Australia: a systematic review and meta-analysis","volume":"12","author":"D Lewis","year":"2012","journal-title":"BMC Infect Dis"},{"issue":"RR-3","key":"ref4","first-page":"1","article-title":"Sexually Transmitted Diseases Treatment Guidelines, 2015","volume":"64","year":"2015","journal-title":"Morb Mortal Wkly Rep"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/jac\/dku574","article-title":"The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis","volume":"70","author":"FYS Kong","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/0956462415618837","article-title":"2015 European guideline on the management of Chlamydia trachomatis infections","volume":"27","author":"E Lanjouw","year":"2016","journal-title":"Int J STD AIDS"},{"key":"ref7","unstructured":"Australian Sexual Health Alliance. Australian STI management guidelines for use in primary care 2014 [20 October 2014]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sti.guidelines.org.au\/sexually-transmissible-infections\/chlamydia#management\" xlink:type=\"simple\">http:\/\/www.sti.guidelines.org.au\/sexually-transmissible-infections\/chlamydia#management<\/ext-link>. Accessed June 2016"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/OLQ.0000000000000092","article-title":"Azithromycin for Rectal Chlamydia: Is it Time to Leave Azithromycin on the Shelf?","volume":"41","author":"SJ Jordan","year":"2014","journal-title":"Not Yet. Sex Transm Dis"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/jac\/dku493","article-title":"Treatment of rectal chlamydia infection may be more complicated than we originally thought","volume":"70","author":"JS Hocking","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl A","key":"ref10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jac\/25.suppl_A.73","article-title":"The pharmacokinetics of azithromycin in human serum and tissues","volume":"25","author":"G Foulds","year":"1990","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"ref11","first-page":"244","article-title":"Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis","volume":"71","author":"AM Worm","year":"1995","journal-title":"Genitourin Med"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/BF01975844","article-title":"Gynecological tissue-levels of azithromycin","volume":"10","author":"K Krohn","year":"1991","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/BF01975843","article-title":"Azithromycin levels in plasma and gastric tissue, juice and mucus","volume":"10","author":"JD Harrison","year":"1991","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"7","key":"ref14","first-page":"361","article-title":"Determination of azithromycin in gastric biopsy samples","volume":"37","author":"RM Kirchhoff","year":"1999","journal-title":"Int J Clin Pharm Ther"},{"key":"ref15","unstructured":"Pfizer Canada. Zithromax product information. Canada, 2013."},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.33.3.277","article-title":"In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection","volume":"33","author":"RP Gladue","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"ref17","unstructured":"Pfizer Australia. Zithromax product information. Australia, 2008."},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0009-9236(97)90098-9","article-title":"Disposition of oral azithromycin in humans","volume":"61","author":"DR Luke","year":"1997","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"ref19","first-page":"265","article-title":"Safety and effectiveness of large-volume enema solutions","volume":"17","author":"M Schmelzer","year":"2004","journal-title":"Appl Nurs Res"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1086\/511279","article-title":"Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission","volume":"195","author":"EJ Fuchs","year":"2007","journal-title":"J Infect Dis"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF01967591","article-title":"Effect of pH variation on the susceptibility of Helicobacter pylori to three macrolide antimicrobial agents and temafloxacin","volume":"12","author":"GJ Malanoski","year":"1993","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.trac.2007.09.004","article-title":"Determination of pKa values of active pharmaceutical ingredients","volume":"26","author":"S Babi\u0107","year":"2007","journal-title":"Trends Anal Chem"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/AAC.47.2.636-642.2003","article-title":"Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp","volume":"47","author":"RJ Suchland","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"issue":"112","key":"ref24","doi-asserted-by":"crossref","first-page":"112re4","DOI":"10.1126\/scitranslmed.3003174","article-title":"Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission","volume":"3","author":"KB Patterson","year":"2011","journal-title":"Sci Transl Med"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"Improving the Reporting Quality of Nonrandomized Evaluations of Behavioral and Public Health Interventions: The TREND Statement","volume":"94","author":"DC Des Jarlais","year":"2004","journal-title":"American Journal of Public Health"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40262-015-0236-8","article-title":"Reporting Guidelines for Clinical Pharmacokinetic Studies: The ClinPK Statement","volume":"54","author":"S Kanji","year":"2015","journal-title":"Clin Pharmacokinet"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Vodstrcil L, Rupasinghe T, F K, Tull D, Worthington K, Chen M, et al. Post-treatment detection of azithromycin in high-vaginal material using liquid chromatography and tandem mass spectrometry (LC-MS\/MS). 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Bitterman","year":"1969","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2165\/00044011-199816020-00009","article-title":"A Phase I Determination of Azithromycin in Plasma during a 6-Week Period in Normal Volunteers after a Standard Dose of 500mg Once Daily for 3 Days","volume":"16","author":"F Crokaert","year":"1998","journal-title":"Clin Drug Investig"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jac\/dkm476","article-title":"Tissue concentrations: do we ever learn?","volume":"61","author":"JW Mouton","year":"2008","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1128\/AAC.50.3.841-851.2006","article-title":"Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages","volume":"50","author":"M 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