{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:13:33Z","timestamp":1783440813772,"version":"3.54.6"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA014089"],"award-info":[{"award-number":["P30CA014089"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["KWF RUG 2014-6698"],"award-info":[{"award-number":["KWF RUG 2014-6698"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["KWF RUG 2014-6698"],"award-info":[{"award-number":["KWF RUG 2014-6698"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["1R01CA206019-01"],"award-info":[{"award-number":["1R01CA206019-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0174457","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T02:04:30Z","timestamp":1490321070000},"page":"e0174457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["HLA expression and HLA type associations in relation to EBV status in Hispanic Hodgkin lymphoma patients"],"prefix":"10.1371","volume":"12","author":[{"given":"Luke B.","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne N.","family":"Veenstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y.","family":"Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amie E.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran N.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouke G.","family":"Hepkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilja M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Cozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Diepstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcancer.2013.07.002","article-title":"The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component","volume":"24","author":"Y Liu","year":"2014","journal-title":"Semin Cancer Biol"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/ijc.27314","article-title":"Tumor microenvironment composition in pediatric classical Hodgkin lymphoma is modulated by age and Epstein-Barr virus infection","volume":"131","author":"MHM Barros","year":"2012","journal-title":"Int J Cancer"},{"key":"ref3","first-page":"261","article-title":"Risk Patterns of Hodgkin\u2019s Disease in Los Angeles Vary by Cell Type","volume":"1","author":"W Cozen","year":"1992","journal-title":"Cancer Epidemiol Biomarkers Prevent"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2141.2004.04902.x","article-title":"Epstein-Barr virus-associated Hodgkin&apos;s lymphoma","volume":"125","author":"MK Gandhi","year":"2004","journal-title":"Br J Haematol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/ajh.23348","article-title":"Hodgkin lymphoma: 2012 update on diagnosis, risk-stratification, and management","volume":"87","author":"SM Ansell","year":"2012","journal-title":"Am J Hematol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T","article-title":"Epstein-Barr virus-associated Hodgkin&apos;s disease: epidemiologic characteristics in international data","volume":"70","author":"SL Glaser","year":"1997","journal-title":"Int J Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02592274","article-title":"Epstein-Barr virus and Hodgkin\u2019s disease","volume":"23","author":"H Herbst","year":"1993","journal-title":"Int J Clin Lab Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1532\/IJH97.05184","article-title":"Epidemiology and pathologic features of Hodgkin lymphoma","volume":"83","author":"S Nakatsuka","year":"2006","journal-title":"Int J Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1158\/1078-0432.CCR-07-1246","article-title":"Tumor infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells","volume":"14","author":"T Alvaro","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/(SICI)1097-0215(19970807)72:4<614::AID-IJC11>3.0.CO;2-B","article-title":"Determination of HLA-A*02 antigen status in Hodgkin\u2019s disease and analysis of an HLA-A*02-restricted epitope of the Epstein-Barr virus LMP-2 protein","volume":"72","author":"H Bryden","year":"1997","journal-title":"Int J Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.4049\/jimmunol.169.4.2172","article-title":"Inhibition of EBV induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope","volume":"169","author":"R Omiya","year":"2012","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/S0140-6736(05)66780-3","article-title":"Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin\u2019s lymphoma","volume":"365","author":"A Diepstra","year":"2005","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1158\/1055-9965.EPI-06-0476","article-title":"The human leukocyte antigen class I region is associated with EBV-positive Hodgkin&apos;s lymphoma: HLA-A and HLA complex group 9 are putative candidate genes","volume":"15","author":"M Niens","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prevent"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1182\/blood-2007-05-086934","article-title":"HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma","volume":"110","author":"M Niens","year":"2007","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/djr516","article-title":"Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein\u2013Barr Virus Status Defined Subgroups","volume":"104","author":"KY Urayama","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1182\/blood-2011-03-343921","article-title":"A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32","volume":"119","author":"W Cozen","year":"2012","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/ncomms4856","article-title":"A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus","volume":"5","author":"W Cozen","year":"2014","journal-title":"Nat Commun"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1182\/blood.V87.9.3844.bloodjournal8793844","article-title":"Analysis of major histocompatibility complex class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus-positive and -negative Hodgkin&apos;s disease","volume":"87","author":"JJ Oudejans","year":"1996","journal-title":"Blood"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood.V92.3.1020","article-title":"Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: analysis of the HLA class I processing pathway and the effects of interleukin-10 on epstein-barr virus-specific cytotoxic T-cell recognition","volume":"92","author":"SP Lee","year":"1998","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1200\/JCO.2006.10.0917","article-title":"HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin\u2019s lymphoma","volume":"25","author":"A Diepstra","year":"2007","journal-title":"J Clin Oncol"},{"issue":"5","key":"ref21","first-page":"e10865","article-title":"Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients","volume":"5","author":"X Huang","year":"2010"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"e31865","DOI":"10.1371\/journal.pone.0031865","article-title":"HLA-A*02:07 Is a Protective Allele for EBV Negative and a Susceptibility Allele for EBV Positive Classical Hodgkin Lymphoma in China","volume":"7","author":"X Huang","year":"2012","journal-title":"PLoS ONE"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2105\/AJPH.2005.068668","article-title":"Latino Populations: A Unique Opportunity for the Study of Race, Genetics, and Social Environment in Epidemiological Research","volume":"95","author":"E Gonz\u00e1lez Burchard","year":"2005","journal-title":"Am J Public Health"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/ijc.23741","article-title":"Racial\/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations","volume":"123","author":"SL Glaser","year":"2008","journal-title":"Int J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1399-0039.2008.01005.x","article-title":"HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin\u2019s lymphoma","volume":"71","author":"A Diepstra","year":"2008","journal-title":"Tissue Antigens"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1038\/leu.2014.201","article-title":"The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing","volume":"28","author":"Y Liu","year":"2014","journal-title":"Leukemia"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/blood-2014-11-610436","article-title":"Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells","volume":"125","author":"J Reichel","year":"2015","journal-title":"Blood"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/cei.12716","article-title":"The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma","volume":"183","author":"K Jones","year":"2016","journal-title":"Clin Exp Immunol"},{"issue":"23","key":"ref29","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/jnci\/94.23.1780","article-title":"Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan","volume":"94","author":"A Hildesheim","year":"2002","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1158\/1055-9965.EPI-14-0683","article-title":"Genetic associations in classical hodgkin lymphoma: a systematic review and insights into susceptibility mechanisms","volume":"23","author":"K Kushekhar","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"e39986","DOI":"10.1371\/journal.pone.0039986","article-title":"HLA associations in classical Hodgkin lymphoma: EBV status matters","volume":"7","author":"X Huang","year":"2012","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0174457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T08:57:50Z","timestamp":1601801870000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0174457"}},"subtitle":[],"editor":[{"given":"Joseph S","family":"Pagano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0174457","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}