{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:51:18Z","timestamp":1775245878348,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"key Program of National Natural Science Foundation of China","award":["30930088"],"award-info":[{"award-number":["30930088"]}]},{"name":"key Program of National Natural Science Foundation of China","award":["81370824"],"award-info":[{"award-number":["81370824"]}]},{"name":"National Program for High Technology Research and Development of China","award":["2012AA020702"],"award-info":[{"award-number":["2012AA020702"]}]},{"name":"National Key Clinical Project"},{"name":"Young scientist fund of NSFC","award":["81400676"],"award-info":[{"award-number":["81400676"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0174505","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T22:29:01Z","timestamp":1490912941000},"page":"e0174505","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A preclinical evaluation of alternative site for islet allotransplantation"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-4109","authenticated-orcid":true,"given":"Chengshi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bole","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shounan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqiu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanrong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"issue":"9374","key":"ref1","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/S0140-6736(03)13680-X","article-title":"Edmonton&apos;s islet success tough to duplicate elsewhere","volume":"361","author":"A Ault","year":"2003","journal-title":"Lancet"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1097\/01.ASN.0000077339.20759.A3","article-title":"Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants","volume":"14","author":"P Fiorina","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1600-6143.2008.02353.x","article-title":"The clinical impact of islet transplantation","volume":"8","author":"P Fiorina","year":"2008","journal-title":"Am J Transplant"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1432-2277.2003.tb00284.x","article-title":"Laparoscopic approach for human islet transplantation into a defined liver segment in type-1 diabetic patients","volume":"16","author":"B Movahedi","year":"2003","journal-title":"Transplant international: official journal of the European Society for Organ Transplantation"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00125-010-1745-5","article-title":"In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver","volume":"53","author":"M Shimoda","year":"2010","journal-title":"Diabetologia"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/TP.0b013e318199c7d2","article-title":"MRI assessment of ischemic liver after intraportal islet transplantation","volume":"87","author":"N Sakata","year":"2009","journal-title":"Transplantation"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/diabetes.48.10.1907","article-title":"Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?","volume":"48","author":"W Bennet","year":"1999","journal-title":"Diabetes"},{"issue":"9350","key":"ref8","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(02)12020-4","article-title":"Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation","volume":"360","author":"L Moberg","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1399-3089.2004.00145.x","article-title":"MyD88-dependent toll-like receptor signalling is not a requirement for fetal islet xenograft rejection in mice","volume":"11","author":"P Schmidt","year":"2004","journal-title":"Xenotransplantation"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1399-3089.2005.00220.x","article-title":"Effect of glucose toxicity on intraportal tilapia islet xenotransplantation in nude mice","volume":"12","author":"A Al-Jazaeri","year":"2005","journal-title":"Xenotransplantation"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2337\/diabetes.55.01.06.db05-0692","article-title":"Natural killer T-cells participate in rejection of islet allografts in the liver of mice","volume":"55","author":"A Toyofuku","year":"2006","journal-title":"Diabetes"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.20050448","article-title":"Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets","volume":"202","author":"Y Yasunami","year":"2005","journal-title":"The Journal of experimental medicine"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00125-011-2091-y","article-title":"The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes","volume":"54","author":"VL Perez","year":"2011","journal-title":"Diabetologia"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-6143.2007.02060.x","article-title":"Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-up","volume":"8","author":"E Rafael","year":"2008","journal-title":"Am J Transplant"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.2337\/db10-0205","article-title":"Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets","volume":"59","author":"G Christoffersson","year":"2010","journal-title":"Diabetes"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3727\/096368910X536527","article-title":"High vascular density and oxygenation of pancreatic islets transplanted in clusters into striated muscle","volume":"20","author":"J Svensson","year":"2011","journal-title":"Cell Transplant"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3727\/096368910X514279","article-title":"Bone marrow and pancreatic islets: an old story with new perspectives","volume":"19","author":"F Ciceri","year":"2010","journal-title":"Cell Transplant"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.2337\/db13-0465","article-title":"Autologous pancreatic islet transplantation in human bone marrow","volume":"62","author":"P Maffi","year":"2013","journal-title":"Diabetes"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1470-2045(08)70180-3","article-title":"Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I\/II study","volume":"9","author":"F Frassoni","year":"2008","journal-title":"Lancet Oncol"},{"issue":"20","key":"ref20","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1182\/blood-2009-03-209973","article-title":"Bone marrow as an alternative site for islet transplantation","volume":"114","author":"E Cantarelli","year":"2009","journal-title":"Blood"},{"issue":"17","key":"ref21","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1182\/blood-2009-12-256826","article-title":"Bone marrow as a site for pancreatic islet transplantation","volume":"115","author":"A Salazar-Banuelos","year":"2010","journal-title":"Blood"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.amjsurg.2007.12.040","article-title":"Pancreatic islet transplantation into the bone marrow of the rat","volume":"195","author":"A Salazar-Banuelos","year":"2008","journal-title":"Am J Surg"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00592-015-0735-y","article-title":"Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site","volume":"52","author":"M Ben Nasr","year":"2015","journal-title":"Acta Diabetol"},{"key":"ref24","article-title":"Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow vs Liver","author":"E Cantarelli","year":"2016","journal-title":"Transplantation"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"e91268","DOI":"10.1371\/journal.pone.0091268","article-title":"Survival of free and encapsulated human and rat islet xenografts transplanted into the mouse bone marrow","volume":"9","author":"RP Meier","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/isl.3.3.15567","article-title":"Bone marrow cavity: a supportive environment for islet engraftment","volume":"3","author":"K Kover","year":"2011","journal-title":"Islets"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00125-008-1030-z","article-title":"Pancreatic islet isolation variables in non-human primates (rhesus macaques)","volume":"51","author":"P Andrades","year":"2008","journal-title":"Diabetologia"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1258\/ebm.2010.009361","article-title":"Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys","volume":"235","author":"X Jin","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI5857","article-title":"CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris","volume":"103","author":"JR Abrams","year":"1999","journal-title":"J Clin Invest"},{"key":"ref30","first-page":"147","article-title":"Implementation of a simplified and cost-effective method for rhesus monkeys islet isolation","volume":"159","author":"C Wang","year":"2015","journal-title":"Sylwan"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/01.tp.0000275401.80187.1e","article-title":"Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model","volume":"84","author":"DM Berman","year":"2007","journal-title":"Transplantation"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.beha.2010.06.003","article-title":"The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases","volume":"23","author":"F Frassoni","year":"2010","journal-title":"Best practice & research Clinical haematology"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1158\/0008-5472.CAN-05-2787","article-title":"Hepatocellular neoplasms induced by low-number pancreatic islet transplants in autoimmune diabetic BB\/Pfd rats","volume":"66","author":"F Dombrowski","year":"2006","journal-title":"Cancer Res"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1097\/TP.0b013e3181bc06b0","article-title":"Histologic graft assessment after clinical islet transplantation","volume":"88","author":"C Toso","year":"2009","journal-title":"Transplantation"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.2337\/diabetes.48.12.2340","article-title":"A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts","volume":"48","author":"T Friedman","year":"1999","journal-title":"Diabetes"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.4049\/jimmunol.170.5.2750","article-title":"T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts","volume":"170","author":"S Yi","year":"2003","journal-title":"J Immunol"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/00007890-200211150-00007","article-title":"Role of CD4+ and CD8+ T cells in the rejection of concordant pancreas xenografts","volume":"74","author":"DP Yin","year":"2002","journal-title":"Transplantation"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1399-3089.2008.00482.x","article-title":"Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation","volume":"15","author":"M Goto","year":"2008","journal-title":"Xenotransplantation"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"M Krampera","year":"2006","journal-title":"Stem Cells"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1634\/stemcells.2004-0359","article-title":"Interactions between human mesenchymal stem cells and natural killer cells","volume":"24","author":"PA Sotiropoulou","year":"2006","journal-title":"Stem Cells"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.2337\/db09-0317","article-title":"Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9","volume":"58","author":"Y Ding","year":"2009","journal-title":"Diabetes"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1634\/stemcells.2007-0554","article-title":"Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells","volume":"26","author":"Z Selmani","year":"2008","journal-title":"Stem Cells"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/eji.201242879","article-title":"Tolerogenic dendritic cells impede priming of naive CD8(+) T cells and deplete memory CD8(+) T cells","volume":"43","author":"FS Kleijwegt","year":"2013","journal-title":"Eur J Immunol"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.4049\/jimmunol.178.11.7018","article-title":"Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance","volume":"178","author":"HR Turnquist","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4049\/jimmunol.1000799","article-title":"Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1","volume":"186","author":"P Fiorina","year":"2011","journal-title":"J Immunol"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/mt.2013.147","article-title":"Third-party mesenchymal stem cells improved human islet transplantation in a humanized diabetic mouse model","volume":"21","author":"H Wu","year":"2013","journal-title":"Mol Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0174505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:44:21Z","timestamp":1588988661000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0174505"}},"subtitle":[],"editor":[{"given":"Paolo","family":"Fiorina","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,30]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0174505","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,30]]}}}