{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:15:08Z","timestamp":1775610908806,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004229","name":"Fondazione Pierfranco e Luisa Mariani","doi-asserted-by":"publisher","award":["CM23"],"award-info":[{"award-number":["CM23"]}],"id":[{"id":"10.13039\/501100004229","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mitocon ONLUS"},{"name":"Cell line and DNA Bank of Genetic Movement Disorders and Mitochondrial Diseases\u201d of Telethon Network of Genetics Biobanks","award":["GTB12001"],"award-info":[{"award-number":["GTB12001"]}]},{"name":"Macula and Genoma Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0174560","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T22:33:32Z","timestamp":1490913212000},"page":"e0174560","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Assessment of the retinal posterior pole in dominant optic atrophy by spectral-domain optical coherence tomography and microperimetry"],"prefix":"10.1371","volume":"12","author":[{"given":"Massimo","family":"Cesareo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ciuffoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Martucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Pietro","family":"Sorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Lamantea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Garavaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cusumano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brancati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0420.1996.tb00672.x","article-title":"Dominant optic atrophy mapped to chromosome 3q region. II. Clinical and epidemiological aspects","volume":"74","author":"B Kjer","year":"1996","journal-title":"Acta Ophthalmol Scand"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.ophtha.2009.12.038","article-title":"The prevalence and natural history of dominant optic atrophy due to OPA1 mutations","volume":"117","author":"P Yu-Wai-Man","year":"2010","journal-title":"Ophthalmology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0002-9394(14)73589-5","article-title":"Visual prognosis in autosomal dominant optic atrophy (Kjer type)","volume":"115","author":"D Eliott","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archopht.116.3.351","article-title":"Clinical features in affected individuals from 21 pedigrees with dominant optic atrophy","volume":"116","author":"M Votruba","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"ref5","first-page":"123","article-title":"Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies","volume":"106","author":"RL Johnston","year":"1999","journal-title":"Ophthalmology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ajo.2006.12.038","article-title":"Autosomal dominant optic atrophy: penetrance and expressivity in patients with OPA1 mutations","volume":"143","author":"AC Cohn","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1755-3768.1983.tb01424.x","article-title":"Histopathology of eye, optic nerve and brain in a case of dominant optic atrophy","volume":"61","author":"P Kjer","year":"1983","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"C Alexander","year":"2000","journal-title":"Nat Genet"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1399-0004.2004.00358.x","article-title":"Sporadic optic atrophy due to synonymous codon change altering mRNA splicing of OPA1","volume":"67","author":"P Amati-Bonneau","year":"2005","journal-title":"Clin Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/hmg\/10.13.1369","article-title":"Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy","volume":"10","author":"C Toomes","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/hmg\/10.13.1359","article-title":"OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance","volume":"10","author":"UE Pesch","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbamcr.2006.04.003","article-title":"Mitochondrial dynamics and disease, OPA1","volume":"1763","author":"A Olichon","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1167\/iovs.03-1407","article-title":"Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network","volume":"46","author":"S Kamei","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies-disease mechanisms and therapeutic strategies","volume":"30","author":"P Yu-Wai-Man","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/mgme.2001.3278","article-title":"OPA1 (Kjer type) dominant optic atrophy: a novel mitochondrial disease","volume":"75","author":"C Delettre","year":"2002","journal-title":"Mol Genet Metab"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/ICU.0b013e3283437222","article-title":"Spectral-domain optical coherence tomography for the diagnosis and follow-up of glaucoma","volume":"22","author":"G Savini","year":"2011","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2004.06.034","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in Leber\u2019s hereditary optic neuropathy","volume":"112","author":"P Barboni","year":"2005","journal-title":"Ophthalmology"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00417-008-0767-x","article-title":"Retinal nerve fiber layer thickness in nonarteritic anterior ischemic optic neuropathy: OCT characterization of the acute and resolving phases","volume":"246","author":"C Bellusci","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1755-3768.2008.01469.x","article-title":"Axonal loss occurs early in dominant optic atrophy","volume":"88","author":"D Milea","year":"2010","journal-title":"Acta Ophthalmol"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.ophtha.2011.02.027","article-title":"Retinal nerve fiber layer thickness in dominant optic atrophy measurements by optical coherence tomography and correlation with age","volume":"118","author":"P Barboni","year":"2011","journal-title":"Ophthalmology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/IJG.0b013e31804d23aa","article-title":"Stratus OCT in dominant optic atrophy: features differentiating it from glaucoma","volume":"16","author":"TW Kim","year":"2007","journal-title":"J Glaucoma"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1167\/iovs.12-10452","article-title":"Mathematically modeling the involvement of axons in Leber\u2019s hereditary optic neuropathy","volume":"53","author":"BX Pan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ophtha.2009.04.013","article-title":"Retinal nerve fiber layer imaging with spectral domain optical coherence tomography: a variability and diagnostic performance study","volume":"116","author":"CK Leung","year":"2009","journal-title":"Ophthalmology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ophtha.2011.12.014","article-title":"Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head","volume":"119","author":"JC Mwanza","year":"2012","journal-title":"Ophthalmology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"121398","DOI":"10.1155\/2013\/121398","article-title":"SDOCT thickness measurements of various retinal layers in patients with autosomal dominant optic atrophy due to OPA1 mutations","volume":"2013","author":"AM Schild","year":"2013","journal-title":"Biomed Res Int"},{"issue":"9","key":"ref26","first-page":"A4888","article-title":"Macular sensitivity and fixation patterns in patients with autosomal dominant optic atrophy","volume":"61","author":"C R\u00f6nnb\u00e4ck","year":"2014","journal-title":"Dan Med J"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1016\/j.ophtha.2013.08.008","article-title":"Imaging of the macula indicates early completion of structural deficit in autosomal dominant optic atrophy","volume":"120","author":"C R\u00f6nnb\u00e4ck","year":"2013","journal-title":"Ophthalmology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"676803","DOI":"10.1155\/2013\/676803","article-title":"High-resolution en face images of microcystic macular edema in patients with autosomal dominant optic atrophy","volume":"2013","author":"K Gocho","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0042-6989(97)00171-5","article-title":"Microperimetry of localized retinal nerve fiber layer defects","volume":"38","author":"N Orzalesi","year":"1998","journal-title":"Vision Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10384-009-0735-y","article-title":"Fixation behavior in advanced stage glaucoma assessed by the MicroPerimeter MP-1","volume":"53","author":"T Kameda","year":"2009","journal-title":"Jpn J Ophthalmol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4172\/2155-9570.1000538","article-title":"Automatic segmentation of posterior pole retinal layers in patients with early Stage Glaucoma Using Spectral Domain Optical Coherence Tomography","volume":"7","author":"M Cesareo","year":"2016","journal-title":"J Clin Exp Ophthalmol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0161-6420(96)30410-7","article-title":"Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography","volume":"103","author":"JS Schuman","year":"1996","journal-title":"Ophthalmology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/IAE.0b013e318196bd65","article-title":"Fixation stability measurement using the MP1 microperimeter","volume":"29","author":"MD Crossland","year":"2009","journal-title":"Retina"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10792-014-9924-x","article-title":"Evaluation of fixation stability using different targets with the MP1 microperimeter","volume":"35","author":"M Cesareo","year":"2015","journal-title":"Int Ophthalmol"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1167\/iovs.07-0024","article-title":"Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations","volume":"48","author":"Y Ito","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00417-014-2852-7","article-title":"Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy","volume":"253","author":"SW Park","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ajo.2014.05.034","article-title":"Early macular retinal ganglion cell loss in dominant optic atrophy: genotype-phenotype correlation","volume":"158","author":"P Barboni","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"e0127906","DOI":"10.1371\/journal.pone.0127906","article-title":"Macular Microcysts in Mitochondrial Optic Neuropathies: Prevalence and Retinal Layer Thickness Measurements","volume":"10","author":"M Carbonelli","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ophtha.2013.08.045","article-title":"Microcystic macular edema in autosomal-dominant otpic atrophy","volume":"121","author":"M Abegg","year":"2014","journal-title":"Ophthalmology"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"A Bringmann","year":"2006","journal-title":"Prog Retin Eye Res"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012864","article-title":"Structure-function correlation of the human central retina","volume":"5","author":"P Charbel Issa","year":"2010","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0174560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T10:31:22Z","timestamp":1719138682000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0174560"}},"subtitle":[],"editor":[{"given":"Sanjoy","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,30]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0174560","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,30]]}}}