{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T03:36:00Z","timestamp":1775964960282,"version":"3.50.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0174929","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T15:29:52Z","timestamp":1491492592000},"page":"e0174929","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Target localization of 3D versus 4D cone beam computed tomography in lipiodol-guided stereotactic radiotherapy of hepatocellular carcinomas"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0187-2703","authenticated-orcid":true,"given":"Mark","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Leung","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venus","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frankle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Blanck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/1471-2407-8-351","article-title":"Stereotactic body radiation therapy with or without transarterial chemoembolization for patients with primary hepatocellular carcinoma: preliminary analysis","volume":"8","author":"B Choi","year":"2008","journal-title":"BMC Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.ijrobp.2011.03.019","article-title":"Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein: Long-term patient outcomes","volume":"82","author":"SM Yoon","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijrobp.2009.07.1730","article-title":"Combination of transarterial chemoembolization and three-dimensional conformal radiotherapy for Hepatocellular carcinoma with inferior vena cava tumor thrombus","volume":"78","author":"JE Koo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.1088\/0031-9155\/56\/17\/001","article-title":"Treatment precision of image-guided liver SBRT using implanted fiducial markers depends on marker\u2013tumour distance","volume":"56","author":"Y Seppenwoolde","year":"2011","journal-title":"Phys Med Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00066-015-0929-9","article-title":"Lipiodol versus diaphragm in 4D-CBCT-guided stereotactic radiotherapy of hepatocellular carcinomas","volume":"192","author":"HMK Chan","year":"2016","journal-title":"Strahlenther Onkol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ijrobp.2014.07.028","article-title":"Is diaphragm motion a good surrogate for liver tumor motion?","volume":"90","author":"J Yang","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1748-717X-7-81","article-title":"Accuracy and inter-observer variability of 3D versus 4D cone-beam CT based image-guidance in SBRT for lung tumors","volume":"7","author":"RA Sweeney","year":"2012","journal-title":"Radiat Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1748-717X-9-77","article-title":"Implementation of single-breath-hold cone beam CT guided hypofraction radiotherapy for lung cancer","volume":"9","author":"R Zhong","year":"2014","journal-title":"Radiat Oncol"},{"key":"ref9","article-title":"Hypofraction radiotherapy of liver tumor using cone beam computed tomography guidance combined with active breath control by long breath-holding","author":"R Zhong","year":"2012","journal-title":"Radiother Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.ijrobp.2007.08.023","article-title":"On-line target position localization in the presence of respiration: A comparison of two methods","volume":"69","author":"GD Hugo","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ijrobp.2009.03.058","article-title":"Inter- and intrafraction variability in liver position in non\u2013breath-hold stereotactic body radiotherapy","volume":"75","author":"RB Case","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1118\/1.1869074","article-title":"Respiratory correlated cone beam CT","volume":"32","author":"J-J Sonke","year":"2005","journal-title":"Med Phys"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.ijrobp.2007.11.042","article-title":"Comparison of different strategies to use four-dimensional computed tomography in treatment planning for lung cancer patients","volume":"70","author":"J Wolthaus","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.prro.2013.07.001","article-title":"Simplified strategies to determine the mean respiratory position for liver radiation therapy planning","volume":"4","author":"M Velec","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1118\/1.3397460","article-title":"Correction of motion artifacts in cone-beam CT using a patient-specific respiratory motion model","volume":"37","author":"Q Zhang","year":"2010","journal-title":"Med Phys"},{"key":"ref16","first-page":"277","article-title":"Effect of transarterial chemoembolisation in unresectable hepatocellular carcinoma with portal vein tumour thrombosis: Single-centre study","volume":"18","author":"KL Siu","year":"2015","journal-title":"HKJR"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S333","DOI":"10.1016\/j.ijrobp.2012.07.876","article-title":"Individualized hypofractionated radiation therapy (IHRT) for advanced hepatocellular carcinoma (HCC)\u2014Single institution experience with 98 Patients","volume":"84","author":"A Lee","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/02841860600936369","article-title":"Individualized image guided iso-NTCP based liver cancer SBRT","volume":"45","author":"LA Dawson","year":"2006","journal-title":"Acta Oncologica"},{"key":"ref19","article-title":"Dosimetric evaluation of four-dimensional dose distributions of CyberKnife and volumetric-modulated arc radiotherapy in stereotactic body lung radiotherapy","volume":"14","author":"MKH Chan","year":"2013","journal-title":"J Appl Clin Med Phys"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1118\/1.2966347","article-title":"Reconstruction of a time-averaged midposition CT scan for radiotherapy planning of lung cancer patients using deformable registration","volume":"35","author":"JWH Wolthaus","year":"2008","journal-title":"Med Phys"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.radonc.2004.12.010","article-title":"Strategies to reduce the systematic error due to tumor and rectum motion in radiotherapy of prostate cancer","volume":"74","author":"MS Hoogeman","year":"2005","journal-title":"Radiother Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijrobp.2008.08.004","article-title":"Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance","volume":"74","author":"J-J Sonke","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"012035","DOI":"10.1088\/1742-6596\/489\/1\/012035","article-title":"Optimized dynamic contrast-enhanced cone-beam CT for target visualization during liver SBRT","volume":"489","author":"BL Jones","year":"2014","journal-title":"J Phys Conf Ser"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"E182","DOI":"10.1016\/j.ijrobp.2015.07.1014","article-title":"Evaluation of 3-D versus 4-D cone beam CT target localization methods for free breathing liver stereotactic body radiation therapy","volume":"93","author":"W Li","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1120\/jacmp.v11i3.3274","article-title":"A comprehensive study on decreasing the kilovoltage cone-beam CT dose by reducing the projection number","volume":"11","author":"B Lu","year":"2010","journal-title":"J Appl Clin Med Phy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.radonc.2011.08.018","article-title":"Comparative study of respiratory motion correction techniques in cone-beam computed tomography","volume":"100","author":"S Rit","year":"2011","journal-title":"Radiother Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2007.10.034","article-title":"MRI\/linac integration","volume":"86","author":"JJW Lagendijk","year":"2008","journal-title":"Radiother Oncol"},{"key":"ref28","unstructured":"Lee P (2016) MRI-guided stereotactic body radiation therapy in treating patients with liver metastases or liver cancer. NCT02683200; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrialsgov\/ct2\/show\/record\/NCT02683200\" xlink:type=\"simple\">http:\/\/clinicaltrialsgov\/ct2\/show\/record\/NCT02683200<\/ext-link>."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0174929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:29:19Z","timestamp":1540268959000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0174929"}},"subtitle":[],"editor":[{"given":"Qinghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0174929","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}