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Hoffman","year":"2002","journal-title":"RadioGraphics"},{"key":"ref13","article-title":"The scientific study of mummies","author":"AC Aufderheide","year":"2003"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"e0133364","DOI":"10.1371\/journal.pone.0133364","article-title":"Checklist and Scoring System for the Assessment of Soft Tissue Preservation in CT Examinations of Human Mummies","volume":"10","author":"S Panzer","year":"2015","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00256-013-1696-2","article-title":"&quot;Modeling ancient Egyptian embalming&quot;: radiological assessment of experimentally mummified human tissue by CT and MRI","volume":"42","author":"S Panzer","year":"2013","journal-title":"Skeletal Radiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1016\/j.jas.2011.08.003","article-title":"New radiological insights into the life and death of the Tyrolean Iceman","volume":"38","author":"P Gostner","year":"2011","journal-title":"J Archaeol Sci"},{"key":"ref17","first-page":"218","article-title":"Diagnostic paleoradiology of mummified tissue: interpretation and pitfalls","volume":"55","author":"F R\u00fchli","year":"2004","journal-title":"Can Assoc Radiol J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1099-1212(200003\/04)10:2<153::AID-OA511>3.0.CO;2-4","article-title":"Radiological aspects and interpretation of post mortem artefacts in ancient Egyptian mummies from Swiss collections","volume":"10","author":"F R\u00fchli","year":"2000","journal-title":"Intern J Osteoarcheol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-2008-1056862","article-title":"Computertomographische Untersuchungen an alt\u00e4gyptischen Mumien","volume":"135","author":"KH 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II. Hypodense bone in postwar Guamanian children","volume":"63","author":"CC Plato","year":"1984","journal-title":"Am J Phys Anthropol"},{"key":"ref31","first-page":"53","article-title":"Die L\u00e4nge der L\u00e4ngsknochen altslawischer Bev\u00f6lkerungen\u2014Unter besonderer Ber\u00fccksichtigung von Wachstumsfragen","volume":"29","author":"M Stloukal","year":"1978","journal-title":"Homo"},{"key":"ref32","unstructured":"Knipe H, Gaillard F. Neurofibromatosis type 1 (NF 1). Radiopaedia.org, the online collaborative radiology resource. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.radiopaedia.org\" xlink:type=\"simple\">http:\/\/www.radiopaedia.org<\/ext-link>. Mai 05, 2016."},{"key":"ref33","first-page":"101","article-title":"Neurofibromtatosis type 1. Symptoms, treatment and prognosis","author":"EK Schorry","year":"2013"},{"key":"ref34","first-page":"I","article-title":"Diagnostic Imaging Brain","author":"SI Blaser","year":"2004"},{"key":"ref35","first-page":"4792","article-title":"Diagnosis of Bone and Joint Disorders","author":"F Feldman","year":"2002"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.2007-3204","article-title":"Neurofibromatosis type 1 revisited","volume":"123","author":"VC Williams","year":"2009","journal-title":"Pediatrics"},{"key":"ref37","first-page":"735","article-title":"Principles and practice of pediatric neurosurgery","author":"JF Pollack","year":"2007"},{"issue":"2","key":"ref38","first-page":"E47","article-title":"The Neurofibromatoses. 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Nati. Acad. Sci. USA"},{"key":"ref57","first-page":"337","article-title":"Radiology Review Manual","author":"W D\u00e4hnert","year":"1999"},{"issue":"Suppl 1","key":"ref58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S0074-02762003000900023","article-title":"Prehistoric tuberculosis in america: adding comments to a literature review","volume":"98","author":"J G\u00f3mez i Prat","year":"2003","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref59","first-page":"208","article-title":"Diseases of the spine in South American mummies","volume":"48","author":"PC Gerszten","year":"2001","journal-title":"Neurosurgery"},{"issue":"4","key":"ref60","first-page":"1267","article-title":"When did Mycobacterium tuberculosis infection first occur in the New World? An important question with public health implications","volume":"151","author":"WW Stead","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"5154","key":"ref61","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.8134831","article-title":"Mummy settles TB antiquity debate","volume":"263","author":"V Morell","year":"1994","journal-title":"Science"},{"issue":"6","key":"ref62","first-page":"985","article-title":"Documentation of a case of tuberculosis in Pre-Columbian America","volume":"107","author":"MJ Allison","year":"1973","journal-title":"Am Rev Respir Dis"},{"issue":"7523","key":"ref63","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature13591","article-title":"Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis","volume":"514","author":"KI Bos","year":"2014","journal-title":"Nature"},{"key":"ref64","first-page":"117","article-title":"The Pacatnamu Papers","volume":"Volume 1","author":"JW Verano","year":"1986"},{"key":"ref65","first-page":"165","article-title":"Ritual sacrifice in ancient Peru","author":"JW Verano","year":"2001"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1017\/S104566350000434X","article-title":"Human Sacrifice at Pachacamac","volume":"19","author":"P Eeckhout","year":"2008","journal-title":"Latin American Antiquity"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jas.2011.10.002","article-title":"Consequences of conquest? 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Human sacrifice at El Brujo, Northern Peru. Report on 2005 Summer Field Research supported by the National Geographic Society\u2019s Committee for Research and Exploration (Grant #7844\u201305) and the Roger Thayer Stone Center for Latin American Studies (Faculty Summer Research Grant). 2006."},{"key":"ref73","first-page":"183","article-title":"Handbook of South American Indians","volume":"vol. 2","author":"JH Rowe","year":"1946"},{"key":"ref74","doi-asserted-by":"crossref","DOI":"10.5040\/9798216963998","article-title":"Daily Life in the Inca Empire","author":"MM Malpass","year":"1996"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T22:09:32Z","timestamp":1750198172000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175000"}},"subtitle":[],"editor":[{"given":"Dong","family":"Hoon Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175000","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}