{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:42:37Z","timestamp":1782718957248,"version":"3.54.5"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Science and Technology Commission Foundation Project","award":["13RCGFSY19200"],"award-info":[{"award-number":["13RCGFSY19200"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175165","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T15:50:58Z","timestamp":1491493858000},"page":"e0175165","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis"],"prefix":"10.1371","volume":"12","author":[{"given":"Qing","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1478-3231.2009.02135.x","article-title":"Nutritional status: its influence on the outcome of patients undergoing liver transplantation","volume":"30","author":"M Merli","year":"2010","journal-title":"Liver Int"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1590\/S0004-28032006000400005","article-title":"Evaluation of nutritional status of nonhospitalized patients with liver cirrhosis","volume":"43","author":"L Carvalho","year":"2006","journal-title":"Arq Gastroenterol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1080\/00365520600825117","article-title":"Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of life","volume":"41","author":"E Kalaitzakis","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1743-422X-7-191","article-title":"Bioelectrical impedance analysis in clinical practice: implications for hepatitis C therapy BIA and hepatitis C","volume":"7","author":"A Kahraman","year":"2010","journal-title":"Virol J"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ejcn.2014.66","article-title":"Impact of body composition on estimated glomerular filtration rate in relatively healthy adults in Taiwan","volume":"69","author":"YW Tsai","year":"2015","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3349\/ymj.2015.56.1.95","article-title":"Reference values of body composition indices: the Korean National Health and Nutrition Examination Surveys","volume":"56","author":"HW Park","year":"2015","journal-title":"Yonsei Med J"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ejcn.2014.203","article-title":"Bioelectrical impedance analysis to estimate body composition in surgical and oncological patients: a systematic review","volume":"69","author":"EB Haverkort","year":"2015","journal-title":"Eur J Clin Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cbi.2014.06.029","article-title":"Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications","volume":"220","author":"YY Zhao","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/liv.12972","article-title":"Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension","volume":"36","author":"S Seijo","year":"2016","journal-title":"Liver Int"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jvh.12122","article-title":"Cross-sectional and dynamic change of serum metabolite profiling for Hepatitis B-related acute-on-chronic liver failure by UPLC\/MS","volume":"21","author":"CY Nie","year":"2014","journal-title":"J Viral Hepat"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s11095-014-1525-x","article-title":"Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS\/MS method","volume":"32","author":"T Yan","year":"2015","journal-title":"Pharm Res"},{"issue":"22","key":"ref12","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1007\/s00216-014-7983-5","article-title":"In vitro\/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC\/MS-MS","volume":"406","author":"A Carretero","year":"2014","journal-title":"Anal Bioanal Chem"},{"key":"ref13","unstructured":"CSoIDaPaCSoHoCM. A. The programme of prevention and cure for viral hepatitis. Chin J Hepatol. 2000:324\u2013329. Epub 2008\/04\/10."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1471-2105-6-179","article-title":"Processing methods for differential analysis of LC\/MS profile data","volume":"6","author":"M Katajamaa","year":"2005","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/pr060594q","article-title":"Chemometrics in metabonomics","volume":"6","author":"J Trygg","year":"2007","journal-title":"J Proteome Res"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/MEG.0b013e32834aa4bb","article-title":"Protein energy malnutrition predicts complications in liver cirrhosis","volume":"23","author":"EJ Huisman","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.dld.2014.12.015","article-title":"Malnutrition assessed through phase angle and its relation to prognosis in patients with compensated liver cirrhosis: a prospective cohort study","volume":"47","author":"A Ruiz-Margain","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cgh.2011.08.016","article-title":"Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition management strategies","volume":"10","author":"K Cheung","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nut.2004.02.002","article-title":"Comparison between handgrip strength, subjective global assessment, and prognostic nutritional index in assessing malnutrition and predicting clinical outcome in cirrhotic outpatients","volume":"21","author":"MR Alvares-da-Silva","year":"2005","journal-title":"Nutrition"},{"issue":"6257","key":"ref20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"JL Goldstein","year":"1990","journal-title":"Nature"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"e0159142","DOI":"10.1371\/journal.pone.0159142","article-title":"Serum Leptin Is a Biomarker of Malnutrition in Decompensated Cirrhosis","volume":"11","author":"V Rachakonda","year":"2016","journal-title":"PLoS One"},{"issue":"24","key":"ref22","first-page":"2255","article-title":"Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation","volume":"45","author":"UJ Tietge","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"690402","DOI":"10.5402\/2012\/690402","article-title":"Nutritional status assessment in cirrhotic patients after protein supplementation","volume":"2012","author":"S Putadechakum","year":"2012","journal-title":"ISRN Gastroenterol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.clnu.2004.06.004","article-title":"Bioelectrical impedance analysis\u2014part I: review of principles and methods","volume":"23","author":"UG Kyle","year":"2004","journal-title":"Clin Nutr"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1194\/jlr.D800028-JLR200","article-title":"Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry","volume":"50","author":"P Wiesner","year":"2009","journal-title":"J Lipid Res"},{"issue":"6","key":"ref26","first-page":"887","article-title":"Lysophosphatidylcholine and lysophosphatidylinosiol\u2014novel promissing signaling molecules and their possible therapeutic activity","volume":"71","author":"A Drzazga","year":"2014","journal-title":"Acta Pol Pharm"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0076-6879(86)29105-3","article-title":"Lysolecithin acyltransferase of human plasma: assay and characterization of enzyme activity","volume":"129","author":"PV Subbaiah","year":"1986","journal-title":"Methods Enzymol"},{"issue":"1","key":"ref28","first-page":"66","article-title":"Nutritional evaluation of the cirrhotic patient: an objective, subjective or multicompartmental approach?","volume":"43","author":"L Ritter","year":"2006","journal-title":"Arq Gastroenterol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/0884533612469027","article-title":"Nutrition assessment and management in advanced liver disease","volume":"28","author":"TM Johnson","year":"2013","journal-title":"Nutr Clin Pract"},{"issue":"25","key":"ref30","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.3748\/wjg.v20.i25.8061","article-title":"Clinical relevance of sarcopenia in patients with cirrhosis","volume":"20","author":"AJ Montano-Loza","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cld.2011.12.009","article-title":"Malnutrition in cirrhosis: contribution and consequences of sarcopenia on metabolic and clinical responses","volume":"16","author":"P Periyalwar","year":"2012","journal-title":"Clin Liver Dis"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jamcollsurg.2010.03.039","article-title":"Sarcopenia and mortality after liver transplantation","volume":"211","author":"MJ Englesbe","year":"2010","journal-title":"J Am Coll Surg"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nut.2014.07.005","article-title":"Sarcopenia impairs prognosis of patients with liver cirrhosis","volume":"31","author":"T Hanai","year":"2015","journal-title":"Nutrition"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cld.2015.04.008","article-title":"Novel Ammonia-Lowering Agents for Hepatic Encephalopathy","volume":"19","author":"RS Rahimi","year":"2015","journal-title":"Clin Liver Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.addr.2015.04.009","article-title":"Recent advances in the treatment of hyperammonemia","volume":"90","author":"S Matoori","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/pr.2015.247","article-title":"Inherited disorders of bilirubin clearance","volume":"79","author":"N Memon","year":"2016","journal-title":"Pediatr Res"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/acs.jproteome.5b00217","article-title":"Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis","volume":"15","author":"X Wang","year":"2016","journal-title":"J Proteome Res"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3349\/ymj.2006.47.6.817","article-title":"Bile acid analysis in biliary tract cancer","volume":"47","author":"JY Park","year":"2006","journal-title":"Yonsei Med J"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/jhep.2000.20524","article-title":"Bioelectrical impedance analysis is a useful bedside technique to assess malnutrition in cirrhotic patients with and without ascites","volume":"32","author":"M Pirlich","year":"2000","journal-title":"Hepatology"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1746.2004.03544.x","article-title":"Effect of liver cirrhosis on body composition: evidence of significant depletion even in mild disease","volume":"20","author":"FA Figueiredo","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"issue":"29","key":"ref41","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.4254\/wjh.v8.i29.1205","article-title":"Nutritional evaluation in cirrhosis: Emphasis on the phase angle","volume":"8","author":"SA Fernandes","year":"2016","journal-title":"World J Hepatol"},{"issue":"4","key":"ref42","first-page":"493","article-title":"Application of total body bioimpedance to the critically ill patient. Brazilian Group for Bioimpedance Study","volume":"4","author":"JA Mattar","year":"1996","journal-title":"New Horiz"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"563","DOI":"10.6061\/clinics\/2015(08)06","article-title":"Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: a ten-year retrospective study","volume":"70","author":"J Xiong","year":"2015","journal-title":"Clinics (Sao Paulo)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:41:53Z","timestamp":1540258913000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175165"}},"subtitle":[],"editor":[{"given":"Han-Chieh","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175165","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}