{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:21:50Z","timestamp":1760955710192},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Health, Labor and Welfare of Japan","award":["National Cancer Center (NCC) Research and Development Fund 36"],"award-info":[{"award-number":["National Cancer Center (NCC) Research and Development Fund 36"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175182","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T15:53:15Z","timestamp":1491493995000},"page":"e0175182","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer"],"prefix":"10.1371","volume":"12","author":[{"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikatoshi","family":"Katada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Doyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Hirao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norisuke","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kawakubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Muto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1200\/JCO.2009.25.4680","article-title":"Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial","volume":"28","author":"M Muto","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0029-1243963","article-title":"Narrow band imaging for detecting superficial squamous cell carcinoma of the head and neck in patients with esophageal squamous cell carcinoma","volume":"42","author":"C Katada","year":"2010","journal-title":"Endoscopy"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1052-5157(18)30053-9","article-title":"Endoscopic mucosal resection for mucosal cancer in the esophagus","volume":"11","author":"H Makuuchi","year":"2001","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.gie.2013.04.182","article-title":"A phase II study of endoscopic submucosal dissection for superficial esophageal neoplasms (KDOG 0901)","volume":"78","author":"K Higuchi","year":"2013","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.gie.2011.04.027","article-title":"Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer","volume":"74","author":"M Muto","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1067\/mge.2001.116877","article-title":"Metachronous squamous cell carcinoma of the esophagus arising after endoscopic mucosal resection","volume":"54","author":"Y Shimizu","year":"2001","journal-title":"Gastrointest Endosc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-2003-38151","article-title":"Head and neck cancer arising after endoscopic mucosal resection for squamous cell carcinoma of the esophagus","volume":"35","author":"Y Shimizu","year":"2003","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1349-7006.2008.00807.x","article-title":"Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study","volume":"99","author":"A Yokoyama","year":"2008","journal-title":"Cancer Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-0029-1214477","article-title":"Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection","volume":"41","author":"Y Urabe","year":"2009","journal-title":"Endoscopy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/ajg.2010.489","article-title":"Lugol-voiding lesions are an important risk factor for a second primary squamous cell carcinoma in patients with esophageal cancer or head and neck cancer","volume":"106","author":"K Hori","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/cam4.705","article-title":"ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma","volume":"5","author":"K Kagemoto","year":"2016","journal-title":"Cancer Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1053\/j.gastro.2016.07.040","article-title":"Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck","volume":"15","author":"C Katada","year":"2016","journal-title":"Gastroenterology"},{"key":"ref13","article-title":"Alcohol beverage consumption and ethyl carbamate (urethane)","volume":"96","year":"2010"},{"key":"ref14","first-page":"99","article-title":"Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males","volume":"5","author":"A Yokoyama","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/carcin\/23.11.1851","article-title":"Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma","volume":"23","author":"A Yokoyama","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1158\/1055-9965.EPI-08-0462","article-title":"Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendlian randomization approach","volume":"18","author":"S Boccia","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1053\/j.gastro.2009.07.070","article-title":"Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk","volume":"137","author":"R Cui","year":"2009","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.3748\/wjg.v16.i33.4210","article-title":"Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis","volume":"16","author":"SJ Yang","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/gut.2009.205724","article-title":"Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and\/or ALDH2 risk alleles","volume":"59","author":"F Tanaka","year":"2010","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/ijc.26296","article-title":"Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men","volume":"130","author":"A Yokoyama","year":"2012","journal-title":"Int J Cancer"},{"key":"ref21","first-page":"1227","article-title":"Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men","volume":"12","author":"T Yokoyama","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1371\/journal.pmed.1000050","article-title":"The alcohol flushing response: an unrecognized risk factor of esophageal cancer from alcohol consumption","volume":"6","author":"PJ Brooks","year":"2009","journal-title":"PLoS Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1158\/1055-9965.EPI-08-0397","article-title":"Health Risk Appraisal Models for Mass Screening of Esophageal Cancer in Japanese Men","volume":"17","author":"T Yokoyama","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/1055-9965.EPI-08-0758","article-title":"Health risk appraisal models for mass screening for esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men","volume":"18","author":"A Yokoyama","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1442-2050.2012.01343.x","article-title":"A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men","volume":"26","author":"A Yokoyama","year":"2013","journal-title":"Dis Esophagus"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1200\/JCO.2003.12.074","article-title":"Risk of second primary malignancy after esophagectomy for squamous cell carcinoma of the thoracic esophagus","volume":"21","author":"T Matsubara","year":"2003","journal-title":"J Clin Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/gut.47.2.256","article-title":"Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients","volume":"47","author":"M Muto","year":"2000","journal-title":"Gut"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/carcin\/bgi035","article-title":"Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region","volume":"26","author":"M Muto","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/lary.23249","article-title":"Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma","volume":"122","author":"C Katada","year":"2012","journal-title":"Laryngoscope"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<1986::AID-CNCR4>3.0.CO;2-F","article-title":"Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics","volume":"77","author":"A Yokoyama","year":"1996","journal-title":"Cancer"},{"key":"ref31","first-page":"895","article-title":"Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers","volume":"11","author":"A Yokoyama","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.0006-341X.2000.00337.x","article-title":"Time-dependent ROC curves for censored survival data and a diagnostic marker","volume":"56","author":"PJ Heagerty","year":"2000","journal-title":"Biometrics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"\u2018\u2018Field cancerization\u201d in oral stratified epithelium","volume":"6","author":"DP Slaughter","year":"1953","journal-title":"Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/carcin\/bgl206","article-title":"Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma","volume":"28","author":"T Asakage","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.fct.2008.05.034","article-title":"The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical survey","volume":"46","author":"DW Lachenmeier","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/ijc.23744","article-title":"Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study","volume":"123","author":"T Yamaji","year":"2008","journal-title":"Int J Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1038\/srep05229","article-title":"Association of fruit and vegetables with the risk of nasopharyngeal cancer: evidence from a meta-analysis","volume":"4","author":"J Jin","year":"2014","journal-title":"Sci Rep"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.1360-0443.2011.03772.x","article-title":"Time pattern of reduction in risk of oesophageal cancer following alcohol cessation\u2013a meta-analysis","volume":"107","author":"J Jarl","year":"2012","journal-title":"Addiction"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.oraloncology.2006.03.007","article-title":"Smoking cessation and the risk of oesophageal cancer: An overview of published studies","volume":"42","author":"C Bosetti","year":"2006","journal-title":"Oral Oncol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10147-010-0056-7","article-title":"Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention","volume":"15","author":"M Morita","year":"2010","journal-title":"Int J Clin Oncol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1530-0277.2006.00053.x","article-title":"Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females","volume":"30","author":"A Yokoyama","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"ref42","first-page":"2065","article-title":"Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females","volume":"12","author":"Y Wang","year":"2011","journal-title":"Asian Pac J Cancer Prev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:21:02Z","timestamp":1588965662000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175182"}},"subtitle":[],"editor":[{"given":"Hyun-Sung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175182","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}