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A prospective double-blind arteriographically controlled trial","volume":"1","author":"H Hess","year":"1985","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF01658734","article-title":"The effect of acetylsalicylic acid on the outcome after lower limb arterial surgery with special reference to cigarette smoking","volume":"15","author":"R Lassila","year":"1991","journal-title":"World J Surg"},{"key":"ref25","first-page":"1016","article-title":"Effects of aspirin and dipyridamole on expanded polytetrafluoroethylene graft patency","volume":"92","author":"RM Green","year":"1982","journal-title":"Surgery"},{"key":"ref26","first-page":"141","article-title":"Prevention of early reocclusion by dipyridamole and ASA in arterial reconstructive surgery","volume":"22","author":"PT Harajola","year":"1981","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"ref27","first-page":"128","article-title":"The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis","volume":"31","author":"K Roztocil","year":"1989","journal-title":"Cor Vasa"},{"key":"ref28","first-page":"1157","article-title":"Use of acetylsalicylic acid in the prevention of re-occlusion following revascularization interventions. Results of a double-blind long term study","volume":"28","author":"U Ehresmann","year":"1977","journal-title":"Med Welt"},{"key":"ref29","unstructured":"Hess H and Keil-Kuri E. Theoretische grundlagen der prophylaxe obliterierender arteriopathien mit aggregationshemmern und ergebnisse einer langzeitstudie mit ASS (Colfarit). In: Marx R, Breddin HK, eds. Proceedings of Colfarit Symposium III. K\u00f6ln, Germany: Bayer; 1975: 80\u201387."},{"key":"ref30","first-page":"68","article-title":"Thrombosen, Embolien und Aggregationshemmer in der Chirurgie","author":"F Zekert","year":"1975"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/jama.300.2.197","article-title":"Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis","volume":"300","author":"FG Fowkes","year":"2008","journal-title":"JAMA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1001\/jama.297.18.2018","article-title":"Aspirin dose for the prevention of cardiovascular disease: a systematic review","volume":"297","author":"CL Campbell","year":"2007","journal-title":"JAMA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"836","DOI":"10.7326\/M16-0577","article-title":"Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force Recommendation Statement","volume":"164","author":"K Bibbins-Domingo","year":"2016","journal-title":"Ann Intern Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jacc.2004.11.041","article-title":"Coronary syndromes following aspirin withdrawal: a special risk for late stent thrombosis","volume":"45","author":"E Ferrari","year":"2005","journal-title":"J Am Coll Cardiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:14:25Z","timestamp":1540340065000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175283"}},"subtitle":[],"editor":[{"given":"Lise Lotte","family":"Gluud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175283","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}