{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:06:27Z","timestamp":1778641587448,"version":"3.51.4"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR 1569\/1-1"],"award-info":[{"award-number":["PR 1569\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175451","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T16:07:30Z","timestamp":1491494850000},"page":"e0175451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Intravitreal injection of \u03b2-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma"],"prefix":"10.1371","volume":"12","author":[{"given":"Fabian","family":"Anders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Teister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Funke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz H.","family":"Grus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solon","family":"Thanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald D.","family":"von Pein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"HA Quigley","year":"1996","journal-title":"The British journal of ophthalmology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"MA Kass","year":"2002","journal-title":"Archives of ophthalmology"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/OPX.0b013e3181890e91","article-title":"Intraocular pressure spikes in keratectasia, axial myopia, and glaucoma","volume":"85","author":"CW McMonnies","year":"2008","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bjo.83.8.980","article-title":"Ganglion cell death in glaucoma: what do we really know?","volume":"83","author":"NN Osborne","year":"1999","journal-title":"The British journal of ophthalmology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0952523805225130","article-title":"Inherited glaucoma in DBA\/2J mice: pertinent disease features for studying the neurodegeneration","volume":"22","author":"RT Libby","year":"2005","journal-title":"Visual neuroscience"},{"issue":"2","key":"ref6","first-page":"349","article-title":"Self-destructive and self-protective processes in the damaged optic nerve: implications for glaucoma","volume":"41","author":"M Schwartz","year":"2000","journal-title":"Investigative ophthalmology & visual science"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/archopht.1996.01100130295012","article-title":"Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma","volume":"114","author":"EB Dreyer","year":"1996","journal-title":"Archives of ophthalmology"},{"issue":"11","key":"ref8","first-page":"3460","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"HA Quigley","year":"2000","journal-title":"Investigative ophthalmology & visual science"},{"issue":"12","key":"ref9","first-page":"2376","article-title":"Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity","volume":"37","author":"J Caprioli","year":"1996","journal-title":"Investigative ophthalmology & visual science"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00055735-199504000-00011","article-title":"Therapeutic rationale for normal-tension glaucoma","volume":"6","author":"RA Hitchings","year":"1995","journal-title":"Current opinion in ophthalmology"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00061198-199906000-00012","article-title":"Vascular dysregulation: a principal risk factor for glaucomatous damage?","volume":"8","author":"J Flammer","year":"1999","journal-title":"Journal of glaucoma"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00055735-200004000-00009","article-title":"The optic nerve head in normal-tension glaucoma","volume":"11","author":"G Tomita","year":"2000","journal-title":"Current opinion in ophthalmology"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-4835(95)80056-5","article-title":"Programmed cell death of retinal ganglion cells during experimental glaucoma","volume":"61","author":"E Garcia-Valenzuela","year":"1995","journal-title":"Experimental eye research"},{"issue":"5","key":"ref14","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"HA Quigley","year":"1995","journal-title":"Investigative ophthalmology & visual science"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle glaucoma","volume":"115","author":"LA Kerrigan","year":"1997","journal-title":"Archives of ophthalmology"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","article-title":"Chronic ocular hypertension following episcleral venous occlusion in rats","volume":"61","author":"SR Shareef","year":"1995","journal-title":"Experimental eye research"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0021-5155(98)00026-4","article-title":"Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink","volume":"42","author":"J Ueda","year":"1998","journal-title":"Japanese journal of ophthalmology"},{"issue":"11","key":"ref18","first-page":"3451","article-title":"Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model","volume":"41","author":"TW Mittag","year":"2000","journal-title":"Investigative ophthalmology & visual science"},{"issue":"9","key":"ref19","first-page":"2962","article-title":"Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma","volume":"43","author":"R Naskar","year":"2002","journal-title":"Investigative ophthalmology & visual science"},{"issue":"6","key":"ref20","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"SW John","year":"1998","journal-title":"Investigative ophthalmology & visual science"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/7741","article-title":"Interacting loci cause severe iris atrophy and glaucoma in DBA\/2J mice","volume":"21","author":"B Chang","year":"1999","journal-title":"Nature genetics"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.exer.2004.02.005","article-title":"Correlation between retinal ganglion cell death and chronically developing inherited glaucoma in a new rat mutant","volume":"79","author":"S Thanos","year":"2004","journal-title":"Experimental eye research"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0007-1935(17)35342-3","article-title":"Glaucoma in the rat","volume":"131","author":"R Heywood","year":"1975","journal-title":"The British veterinary journal"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/OPX.0b013e3181fc329f","article-title":"Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma","volume":"88","author":"A Ghaffariyeh","year":"2011","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.mcn.2007.11.002","article-title":"Crystallins of the beta\/gamma-superfamily mimic the effects of lens injury and promote axon regeneration","volume":"37","author":"D Fischer","year":"2008","journal-title":"Molecular and cellular neurosciences"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1074\/mcp.M600245-MCP200","article-title":"Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2)","volume":"6","author":"T Liedtke","year":"2007","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"6","key":"ref27","first-page":"1743","article-title":"Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease","volume":"143","author":"MW Head","year":"1993","journal-title":"The American journal of pathology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF00296796","article-title":"alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease","volume":"83","author":"K Renkawek","year":"1992","journal-title":"Acta neuropathologica"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/02713680701375183","article-title":"Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor","volume":"32","author":"SC Joachim","year":"2007","journal-title":"Current eye research"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3727\/096368914X684583","article-title":"betaB2-Crystallin Promotes Axonal Regeneration in the Injured Optic Nerve in Adult Rats","volume":"24","author":"MR Bohm","year":"2015","journal-title":"Cell transplantation"},{"issue":"1","key":"ref31","first-page":"63","article-title":"Effects of crystallin-beta-b2 on stressed RPE in vitro and in vivo. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle","volume":"251","author":"MR Bohm","year":"2013","journal-title":"Ophthalmologie"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.1167\/iovs.12-10334","article-title":"Crystallin-beta-b2-overexpressing NPCs support the survival of injured retinal ganglion cells and photoreceptors in rats","volume":"53","author":"MR Bohm","year":"2012","journal-title":"Investigative ophthalmology & visual science"},{"issue":"15\u201316","key":"ref33","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.molimm.2011.07.012","article-title":"Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma","volume":"48","author":"P Jha","year":"2011","journal-title":"Molecular immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.11.095","article-title":"Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration","volume":"1141","author":"N Piri","year":"2007","journal-title":"Brain research"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.exer.2006.03.002","article-title":"Retinal synthesis and deposition of complement components induced by ocular hypertension","volume":"83","author":"MH Kuehn","year":"2006","journal-title":"Experimental eye research"},{"issue":"D1","key":"ref36","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"JA Vizcaino","year":"2016","journal-title":"Nucleic acids research"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.08-3267","article-title":"Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas","volume":"50","author":"FM Nadal-Nicolas","year":"2009","journal-title":"Investigative ophthalmology & visual science"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/IJG.0b013e31818c6ef6","article-title":"Friend or foe? Resolving the impact of glial responses in glaucoma","volume":"18","author":"EC Johnson","year":"2009","journal-title":"Journal of glaucoma"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"M111","DOI":"10.1074\/mcp.M111.012302","article-title":"Proteomics analyses of human optic nerve head astrocytes following biomechanical strain","volume":"11","author":"RS Rogers","year":"2012","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1167\/iovs.03-1047","article-title":"Temporal changes in gene expression after injury in the rat retina","volume":"45","author":"F Vazquez-Chona","year":"2004","journal-title":"Investigative ophthalmology & visual science"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00296185","article-title":"Expression of alpha B-crystallin in Alzheimer's disease","volume":"87","author":"K Renkawek","year":"1994","journal-title":"Acta neuropathologica"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1097\/00001756-199908020-00009","article-title":"Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease","volume":"10","author":"K Renkawek","year":"1999","journal-title":"Neuroreport"},{"key":"ref43","first-page":"1199","article-title":"Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure","volume":"12","author":"R Naskar","year":"2006","journal-title":"Molecular vision"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"e33593","DOI":"10.1371\/journal.pone.0033593","article-title":"Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model","volume":"7","author":"M Schallenberg","year":"2012","journal-title":"PloS one"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000027470","article-title":"Vascular and glial changes in the retrolaminar optic nerve in glaucomatous monkey eyes","volume":"214","author":"N Furuyoshi","year":"2000","journal-title":"Ophthalmologica Journal international d'ophtalmologie International journal of ophthalmology Zeitschrift fur Augenheilkunde"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/exnr.2001.7822","article-title":"Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats","volume":"172","author":"D Fischer","year":"2001","journal-title":"Experimental neurology"},{"issue":"40","key":"ref47","first-page":"8726","article-title":"Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. The Journal of neuroscience: the official journal of the","volume":"24","author":"D Fischer","year":"2004","journal-title":"Society for Neuroscience"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s12035-013-8470-2","article-title":"Crystallins in retinal ganglion cell survival and regeneration","volume":"48","author":"N Piri","year":"2013","journal-title":"Molecular neurobiology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.preteyeres.2016.03.001","article-title":"Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival","volume":"52","author":"N Piri","year":"2016","journal-title":"Progress in retinal and eye research"},{"issue":"11","key":"ref50","first-page":"3575","article-title":"Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin","volume":"43","author":"CS Alge","year":"2002","journal-title":"Investigative ophthalmology & visual science"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2004.06.015","article-title":"Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF\/MEK\/ERK and AKT signaling pathways","volume":"79","author":"JP Liu","year":"2004","journal-title":"Experimental eye research"},{"issue":"19","key":"ref52","doi-asserted-by":"crossref","first-page":"16059","DOI":"10.1074\/jbc.C100107200","article-title":"The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation","volume":"276","author":"MC Kamradt","year":"2001","journal-title":"The Journal of biological chemistry"},{"key":"ref53","first-page":"1","article-title":"Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice","volume":"13","author":"KH Jung","year":"2014","journal-title":"Molecular imaging"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.bbrc.2003.12.032","article-title":"Anisomycin superinduces annexin V mRNA expression through the ERK1\/2 but not the p38 MAP kinase pathway","volume":"313","author":"Y Konishi","year":"2004","journal-title":"Biochemical and biophysical research communications"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"ML Circu","year":"2010","journal-title":"Free radical biology & medicine"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/02713688909000028","article-title":"Lens crystallins in aqueous and vitreous humor in selenite overdose cataract","volume":"8","author":"H Watanabe","year":"1989","journal-title":"Current eye research"},{"issue":"10","key":"ref57","doi-asserted-by":"crossref","first-page":"e12578","DOI":"10.1371\/journal.pone.0012578","article-title":"alphaB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells","volume":"5","author":"PG Sreekumar","year":"2010","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T14:54:54Z","timestamp":1568991294000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175451"}},"subtitle":[],"editor":[{"given":"Kin-Sang","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175451","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}