{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:29:32Z","timestamp":1774265372902,"version":"3.50.1"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2002-00610"],"award-info":[{"award-number":["200-2002-00610"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2002-00611"],"award-info":[{"award-number":["200-2002-00611"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2002-00612"],"award-info":[{"award-number":["200-2002-00612"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2002-00613"],"award-info":[{"award-number":["200-2002-00613"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2007-23633"],"award-info":[{"award-number":["200-2007-23633"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2007-23634"],"award-info":[{"award-number":["200-2007-23634"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2007-26635"],"award-info":[{"award-number":["200-2007-26635"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2007-23636"],"award-info":[{"award-number":["200-2007-23636"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institues of Health","doi-asserted-by":"crossref","award":["1KL2RR033182-01"],"award-info":[{"award-number":["1KL2RR033182-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175517","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T13:31:00Z","timestamp":1493731860000},"page":"e0175517","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-0011","authenticated-orcid":true,"given":"Maura","family":"Manion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine Huppler","family":"Hullsiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor M. P.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rhame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erna","family":"Kojic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragna","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason V.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irini","family":"Sereti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Study to Understand the Natural History of HIV\/AIDS in the Era of Effective Antiretroviral Therapy (the \u2018SUN Study\u2019) Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/infdis\/jiu259","article-title":"25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings","volume":"210","author":"F Havers","year":"2014","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/infdis\/jiu074","article-title":"Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons","volume":"210","author":"L Shepherd","year":"2014","journal-title":"The Journal of infectious diseases"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2334-13-7","article-title":"Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients","volume":"13","author":"T Ansemant","year":"2013","journal-title":"BMC infectious diseases"},{"issue":"10","key":"ref4","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1371\/journal.pmed.0050203","article-title":"Inflammatory and coagulation biomarkers and mortality in patients with HIV infection","volume":"5","author":"LH Kuller","year":"2008","journal-title":"PLoS medicine"},{"key":"ref5","unstructured":"Grund B, Baker J, Deeks SG, Wolfson J, Wentworth D, Cozzi-Lepri A, et al., editor Combined effect of interleukin-6 and D-dimer on the risk of serious non-AIDS conditions: data from 3 prospective cohorts. 20th Conference on Retroviruses and Opportunistic Infections; Atlanta, GA: CROI, LLC; 2013."},{"issue":"9","key":"ref6","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1093\/infdis\/jiu275","article-title":"Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection","volume":"210","author":"EM Wilson","year":"2014","journal-title":"The Journal of infectious diseases"},{"issue":"6","key":"ref7","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1097\/QAD.0000000000000145","article-title":"Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort","volume":"28","author":"JV Baker","year":"2014","journal-title":"Aids"},{"issue":"5","key":"ref8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/aje\/kwn361","article-title":"The study to understand the natural history of HIV and AIDS in the era of effective therapy (SUN Study)","volume":"169","author":"C Vellozzi","year":"2009","journal-title":"American journal of epidemiology"},{"issue":"7","key":"ref9","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"MF Holick","year":"2011","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"3","key":"ref10","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/cid\/ciq158","article-title":"Low vitamin D among HIV-infected adults: prevalence of and risk factors for low vitamin D Levels in a cohort of HIV-infected adults and comparison to prevalence among adults in the US general population","volume":"52","author":"CN Dao","year":"2011","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"6","key":"ref11","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1093\/infdis\/jit581","article-title":"Evidence for innate immune system activation in HIV type 1-infected elite controllers","volume":"209","author":"S Krishnan","year":"2014","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/icb.2013.84","article-title":"Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals","volume":"92","author":"CL Westhorpe","year":"2014","journal-title":"Immunology and cell biology"},{"key":"ref13","first-page":"14","article-title":"Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy","volume":"500","author":"V Fabre-Mersseman","year":"2014","journal-title":"Aids"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"903680","DOI":"10.1155\/2014\/903680","article-title":"Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB\/HIV","volume":"2014","author":"AK Coussens","year":"2014","journal-title":"Scientifica"},{"issue":"12","key":"ref15","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1001\/archinte.168.12.1340","article-title":"Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality","volume":"168","author":"H Dobnig","year":"2008","journal-title":"Arch Intern Med"},{"issue":"5","key":"ref16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1111\/j.1365-2265.2009.03548.x","article-title":"Vitamin D and mortality in older men and women","volume":"71","author":"S Pilz","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"ref17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1017\/S0029665111001650","article-title":"Vitamin D and immune function: an overview","volume":"71","author":"M Hewison","year":"2012","journal-title":"The Proceedings of the Nutrition Society"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:23:47Z","timestamp":1540340627000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175517"}},"subtitle":[],"editor":[{"given":"Aftab A.","family":"Ansari","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175517","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]}}}