{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:37:35Z","timestamp":1780677455588,"version":"3.54.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01575"],"award-info":[{"award-number":["PI16\/01575"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01823"],"award-info":[{"award-number":["PI14\/01823"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Salud y Bienestar Social de la Junta de Andaluc\u00eda","award":["PI-0471\/2013"],"award-info":[{"award-number":["PI-0471\/2013"]}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS-7685"],"award-info":[{"award-number":["CTS-7685"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CVI-02526"],"award-info":[{"award-number":["CVI-02526"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Salud y Bienestar Social de la Junta de Andaluc\u00eda","award":["PI-0437-2012"],"award-info":[{"award-number":["PI-0437-2012"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175560","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T14:30:29Z","timestamp":1491921029000},"page":"e0175560","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease"],"prefix":"10.1371","volume":"12","author":[{"given":"Ismael","family":"Huertas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Jes\u00fas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Garc\u00eda-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Lojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Bernal-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bonilla-Toribio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Mart\u00edn-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Garc\u00eda-Sol\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"G\u00f3mez-Garre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11910-011-0203-1","article-title":"Mild cognitive impairment in Parkinson&apos;s disease","volume":"11","author":"D Aarsland","year":"2011","journal-title":"Current neurology and neuroscience reports"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/mds.25853","article-title":"Cognitive deficits in Parkinson&apos;s disease: a cognitive neuroscience perspective","volume":"29","author":"TW Robbins","year":"2014","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000341998","article-title":"Cognitive impairment in Parkinson&apos;s disease: the dual syndrome hypothesis","volume":"11","author":"AA Kehagia","year":"2013","journal-title":"Neuro-degenerative diseases"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fneur.2013.00090","article-title":"Imaging of Dopamine in PD and Implications for Motor and Neuropsychiatric Manifestations of PD","volume":"4","author":"R de la Fuente-Fernandez","year":"2013","journal-title":"Frontiers in neurology"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.biopsych.2005.12.017","article-title":"Imaging in Parkinson&apos;s disease: the role of monoamines in behavior","volume":"59","author":"DJ Brooks","year":"2006","journal-title":"Biological psychiatry"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/mds.25846","article-title":"What can biomarkers tell us about cognition in Parkinson&apos;s disease?","volume":"29","author":"B Mollenhauer","year":"2014","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"Pt 10","key":"ref7","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/brain\/awu201","article-title":"Genetic impact on cognition and brain function in newly diagnosed Parkinson&apos;s disease: ICICLE-PD study","volume":"137","author":"C Nombela","year":"2014","journal-title":"Brain: a journal of neurology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00415-009-0119-8","article-title":"Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson&apos;s disease","volume":"256","author":"CH Williams-Gray","year":"2009","journal-title":"Journal of neurology"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1001\/jamaneurol.2014.1455","article-title":"APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease","volume":"71","author":"IF Mata","year":"2014","journal-title":"JAMA neurology"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/archneurol.2011.17","article-title":"Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes","volume":"68","author":"N Seto-Salvia","year":"2011","journal-title":"Archives of neurology"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/jnnp-2013-305277","article-title":"The CamPaIGN study of Parkinson&apos;s disease: 10-year outlook in an incident population-based cohort","volume":"84","author":"CH Williams-Gray","year":"2013","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10048-011-0292-7","article-title":"Genetic variability in SNCA and Parkinson&apos;s disease","volume":"12","author":"L Pihlstrom","year":"2011","journal-title":"Neurogenetics"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson&apos;s disease","volume":"361","author":"E Sidransky","year":"2009","journal-title":"The New England journal of medicine"},{"issue":"Pt 7","key":"ref14","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson&apos;s disease","volume":"132","author":"J Neumann","year":"2009","journal-title":"Brain: a journal of neurology"},{"issue":"Pt 2","key":"ref15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/brain\/aws318","article-title":"Glucocerebrosidase mutations influence the natural history of Parkinson&apos;s disease in a community-based incident cohort","volume":"136","author":"SE Winder-Rhodes","year":"2013","journal-title":"Brain: a journal of neurology"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson&apos;s disease","volume":"22","author":"M Emre","year":"2007","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/mds.22877","article-title":"PDD-Short Screen: a brief cognitive test for screening dementia in Parkinson&apos;s disease","volume":"25","author":"J Pagonabarraga","year":"2010","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"e0167749","DOI":"10.1371\/journal.pone.0167749","article-title":"GBA Variants Influence Motor and Non-Motor Features of Parkinson&apos;s Disease","volume":"11","author":"S Jesus","year":"2016","journal-title":"PloS one"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00259-014-2882-8","article-title":"Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson&apos;s disease using [(123)I]FP-CIT SPECT","volume":"42","author":"I Huertas-Fernandez","year":"2015","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2967\/jnumed.111.095224","article-title":"Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy","volume":"53","author":"M Oh","year":"2012","journal-title":"Journal of nuclear medicine: official publication, Society of Nuclear Medicine"},{"issue":"Suppl 7","key":"ref21","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1002\/mds.10579","article-title":"Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it?","volume":"18","author":"W Pirker","year":"2003","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.nbd.2012.02.002","article-title":"A large study reveals no association between APOE and Parkinson&apos;s disease","volume":"46","author":"M Federoff","year":"2012","journal-title":"Neurobiology of disease"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1007\/s00259-005-1922-9","article-title":"The effect of levodopa therapy on dopamine transporter SPECT imaging with (123)I-FP-CIT in patients with Parkinson&apos;s disease","volume":"32","author":"O Schillaci","year":"2005","journal-title":"European journal of nuclear medicine and molecular imaging"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1212\/01.WNL.0000130159.28215.6A","article-title":"APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease","volume":"62","author":"X Huang","year":"2004","journal-title":"Neurology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.21192","article-title":"Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson&apos;s disease","volume":"62","author":"A Goris","year":"2007","journal-title":"Annals of neurology"},{"issue":"Pt 8","key":"ref26","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/brain\/aws157","article-title":"The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson&apos;s disease: a PET study","volume":"135","author":"K Wu","year":"2012","journal-title":"Brain: a journal of neurology"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.parkreldis.2015.02.009","article-title":"Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson&apos;s disease","volume":"21","author":"J Muellner","year":"2015","journal-title":"Parkinsonism & related disorders"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2008.10.018","article-title":"Lack of association of APOE and tau polymorphisms with dementia in Parkinson&apos;s disease","volume":"448","author":"M Ezquerra","year":"2008","journal-title":"Neuroscience letters"},{"issue":"Pt 8","key":"ref29","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/brain\/aws174","article-title":"The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow","volume":"135","author":"O Goker-Alpan","year":"2012","journal-title":"Brain: a journal of neurology"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"e69190","DOI":"10.1371\/journal.pone.0069190","article-title":"Dopaminergic neuronal imaging in genetic Parkinson&apos;s disease: insights into pathogenesis","volume":"8","author":"A McNeill","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.23614","article-title":"Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains","volume":"72","author":"ME Gegg","year":"2012","journal-title":"Annals of neurology"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/mds.26071","article-title":"GBA-associated Parkinson&apos;s disease: reduced survival and more rapid progression in a prospective longitudinal study","volume":"30","author":"K Brockmann","year":"2015","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/mds.26359","article-title":"GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson&apos;s disease","volume":"31","author":"IF Mata","year":"2016","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"Pt 9","key":"ref34","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/brain\/awv179","article-title":"Glucocerebrosidase activity in Parkinson&apos;s disease with and without GBA mutations","volume":"138","author":"RN Alcalay","year":"2015","journal-title":"Brain: a journal of neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:41:04Z","timestamp":1540280464000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175560"}},"subtitle":[],"editor":[{"given":"Mathias","family":"Toft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175560","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]}}}