{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:34:16Z","timestamp":1781944456758,"version":"3.54.5"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175625","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T14:07:14Z","timestamp":1492092434000},"page":"e0175625","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-7399","authenticated-orcid":true,"given":"Bei","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Qing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong-Hua","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Hua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Sheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Lin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-You","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ming","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/apt.13497","article-title":"Review article: the global emergence of <italic>Helicobacter pylori<\/italic> antibiotic resistance","volume":"43","author":"I Thung","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of <italic>Helicobacter pylori<\/italic> infection\u2013the Maastricht V\/Florence Consensus Report","volume":"66","author":"P Malfertheiner","year":"2017","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Faculty members of Kyoto Global Consensus Conference. Kyoto global consensus report on <italic>Helicobacter pylori<\/italic> gastritis","volume":"64","author":"K Sugano","year":"2015","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/1751-2980.12034","article-title":"Fourth Chinese National Consensus Report on the management of <italic>Helicobacter pylori<\/italic> infection","volume":"14","author":"WZ Liu","year":"2013","journal-title":"J Dig Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/gutjnl-2015-311019","article-title":"Role of bismuth in improving <italic>Helicobacter pylori<\/italic> eradication with triple therapy","volume":"65","author":"MP Dore","year":"2016","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1523-5378.2012.00971.x","article-title":"<italic>Helicobacter pylori<\/italic> eradication with ecabet sodium, omeprazole, amoxicillin, and clarithromycin versus bismuth, omeprazole, amoxicillin, and clarithromycin quadruple therapy: a randomized, open-label, phase IV trial","volume":"17","author":"J Liang","year":"2012","journal-title":"Helicobacter"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-2036.1999.00510.x","article-title":"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxicillin and clarithromycin increases the cure rate of <italic>Helicobacter pylori<\/italic> infection","volume":"13","author":"H Kashimura","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12011-014-9943-5","article-title":"Oral treatment of pressure ulcers with polaprezinc (zinc <sc>l<\/sc>-carnosine complex): 8-week open-label trial","volume":"158","author":"K Sakae","year":"2014","journal-title":"Biol Trace Elem Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/09674845.2014.11669962","article-title":"Zinc chloride inhibits <italic>Helicobacter pylori<\/italic> growth and reduces expression of interleukin-1beta by gastric epithelial cells","volume":"71","author":"J Yakoob","year":"2014","journal-title":"Br J Biomed Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1523-5378.2002.00114.x","article-title":"Polaprezinc attenuates <italic>Helicobacter pylori<\/italic>-associated gastritis in Mongolian gerbils","volume":"7","author":"R Ishihara","year":"2002","journal-title":"Helicobacter"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/14756360903179518","article-title":"Mechanochemical synthesis and in vitro anti-<italic>Helicobacter pylori<\/italic> and uresase inhibitory activities of novel zinc(II)-famotidine complex","volume":"25","author":"M Amin","year":"2010","journal-title":"J Enzyme Inhib Med Chem"},{"key":"ref12","first-page":"817","article-title":"Applicability of zinc complex of <sc>l<\/sc>-carnosine for medical use","volume":"65","author":"T Matsukura","year":"2000","journal-title":"Biochemistry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-230X-13-108","article-title":"Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study","volume":"13","author":"I Watari","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/0884533613493333","article-title":"Effects of <sc>l<\/sc>-carnosine and its zinc complex (Polaprezinc) on pressure ulcer healing","volume":"28","author":"K Sakae","year":"2013","journal-title":"Nutr Clin Pract"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/ijc.25200","article-title":"Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer","volume":"127","author":"T Watanabe","year":"2010","journal-title":"Int J Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/mdr.2013.0086","article-title":"Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of <italic>Helicobacter pylori<\/italic>","volume":"20","author":"J Yakoob","year":"2014","journal-title":"Microb Drug Resist"},{"key":"ref17","first-page":"A138","article-title":"Zinc compound is a novel, highly effective triple therapy for eradication of <italic>Helicobacter pylori<\/italic>","volume":"108","author":"H Kuwayama","year":"1995","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.dld.2014.08.038","article-title":"Prospective multi-region study on primary antibiotic resistance of <italic>Helicobacter pylori<\/italic> strains isolated from Chinese patients","volume":"46","author":"Z Song","year":"2014","journal-title":"Dig Liver Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ajg.2014.26","article-title":"A comparative study of sequential therapy and standard triple therapy for <italic>Helicobacter pylori<\/italic> infection: a randomized multicenter trial","volume":"109","author":"L Zhou","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/hel.12242","article-title":"Tailored versus triple plus bismuth or concomitant therapy as initial <italic>Helicobacter pylori<\/italic> treatment: A randomized trial","volume":"21","author":"L Zhou","year":"2016","journal-title":"Helicobacter"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/hel.12287","article-title":"Hp-normogram (normo-graham) for assessing the outcome of <italic>H<\/italic>. <italic>pylori<\/italic> therapy: Effect of resistance, duration, and CYP2C19 genotype","volume":"21","author":"DY Graham","year":"2016","journal-title":"Helicobacter"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T21:58:05Z","timestamp":1569016685000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175625"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175625","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}