{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:28:03Z","timestamp":1772767683631,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"the National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2014R1A2A2A01004899"],"award-info":[{"award-number":["NRF-2014R1A2A2A01004899"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Agri-Bio Industry Technology Development Program","award":["315030-03-1-HD020"],"award-info":[{"award-number":["315030-03-1-HD020"]}]},{"name":"the Ministry of Health and Welfare, Republic of Korea","award":["HI15C2928"],"award-info":[{"award-number":["HI15C2928"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175644","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T14:08:56Z","timestamp":1492092536000},"page":"e0175644","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection"],"prefix":"10.1371","volume":"12","author":[{"given":"Su-Hwa","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ah-Ra","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jick","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-9339","authenticated-orcid":true,"given":"Fu-Shi","family":"Quan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"ref1","first-page":"e90203","article-title":"Toxoplasmosis\u2013a global threat","volume":"9","author":"J Flegr","year":"2014","journal-title":"Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pt.2004.08.008","article-title":"Zoonotic protozoa: from land to sea","volume":"20","author":"R Fayer","year":"2004","journal-title":"Trends Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1645\/GE-683.1","article-title":"Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers","volume":"91","author":"J Dubey","year":"2005","journal-title":"J Parasitol"},{"key":"ref4","first-page":"1117","article-title":"Vaccination against Toxoplasma gondii: an increasing priority for collaborative research?","volume":"9","author":"EA Innes","year":"2010"},{"key":"ref5","first-page":"e0161231","article-title":"Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii","volume":"11","author":"DH Lee","year":"2016"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.exppara.2008.03.016","article-title":"Toxoplasma gondii: serological characterization and immunogenicity of recombinant surface antigen 2 (SAG2) expressed in the yeast Pichia pastoris","volume":"119","author":"YL Lau","year":"2008","journal-title":"Exp Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1016\/j.vaccine.2005.04.025","article-title":"Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice","volume":"23","author":"M M\u00e9v\u00e9lec","year":"2005","journal-title":"Vaccine"},{"key":"ref8","first-page":"1561","article-title":"Induction of immune responses in mice by vaccination with Liposome-entrapped DNA complexes encoding Toxoplasma gondii SAG1 and ROP1 genes","volume":"116","author":"H Chen","year":"2003","journal-title":"Chin Med J (Engl)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.parint.2007.04.003","article-title":"Immune response induced by recombinant Mycobacterium bovis BCG expressing ROP2 gene of Toxoplasma gondii","volume":"56","author":"H Wang","year":"2007","journal-title":"Parasitol Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.vaccine.2007.11.058","article-title":"An enhanced GRA1\u2013GRA7 cocktail DNA vaccine primes anti-Toxoplasma immune responses in pigs","volume":"26","author":"E Jongert","year":"2008","journal-title":"Vaccine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.micinf.2005.11.013","article-title":"Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii","volume":"8","author":"EV Louren\u00e7o","year":"2006","journal-title":"Microb Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1016\/j.vaccine.2009.08.043","article-title":"Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice","volume":"27","author":"G Peng","year":"2009","journal-title":"Vaccine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00436-010-1742-0","article-title":"Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis","volume":"106","author":"M Liu","year":"2010","journal-title":"Parasitol Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"S Besteiro","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.mib.2013.07.004","article-title":"Key molecular events during host cell invasion by Apicomplexan pathogens","volume":"16","author":"P Sharma","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"ref16","first-page":"e0143087","article-title":"Vaccination with Recombinant Microneme Proteins Confers Protection against Experimental Toxoplasmosis in Mice","volume":"10","author":"CF Pinzan","year":"2015"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/j.vaccine.2014.03.042","article-title":"Synergy of mIL-21 and mIL-15 in enhancing DNA vaccine efficacy against acute and chronic Toxoplasma gondii infection in mice","volume":"32","author":"Z Li","year":"2014","journal-title":"Vaccine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00436-010-1742-0","article-title":"Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis","volume":"106","author":"M Liu","year":"2010","journal-title":"Parasitol Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/CVI.00397-12","article-title":"Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice","volume":"19","author":"PY Wang","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.vaccine.2013.01.027","article-title":"Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice","volume":"31","author":"J Chen","year":"2013","journal-title":"Vaccine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"17200","DOI":"10.1073\/pnas.1007610107","article-title":"Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii","volume":"107","author":"BR Joyce","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.vaccine.2009.12.005","article-title":"Construction and immunogenicity of pseudotype baculovirus expressing Toxoplasma gondii SAG1 protein in BALB\/c mice model","volume":"28","author":"R Fang","year":"2010","journal-title":"Vaccine"},{"key":"ref23","first-page":"384","article-title":"Evaluation of protective efficacy induced by virus-like particles containing a Trichinella spiralis excretory-secretory (ES) protein in mice","volume":"9","author":"S Lee","year":"2016"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/j.biomaterials.2012.01.054","article-title":"Stability of influenza vaccine coated onto microneedles","volume":"33","author":"H Choi","year":"2012","journal-title":"Biomaterials"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1128\/JVI.02052-06","article-title":"Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus","volume":"81","author":"FS Quan","year":"2007","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.exppara.2012.01.005","article-title":"Toxoplasma gondii antigens: recovery analysis of tachyzoites cultivated in Vero cell maintained in serum free medium","volume":"130","author":"TA da Costa-Silva","year":"2012","journal-title":"Exp Parasitol"},{"key":"ref27","first-page":"461","article-title":"Eficiencia de cultivo in vitro de Toxoplasma gondii en las l\u00edneas celulares THP1 y Vero","volume":"32","author":"JA Cuellar","year":"2012"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetimm.2012.04.026","article-title":"Virus-like particles: the new frontier of vaccines for animal viral infections","volume":"148","author":"E Crisci","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/infdis\/jir474","article-title":"Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice","volume":"204","author":"FS Quan","year":"2011","journal-title":"J Infect Dis"},{"key":"ref30","first-page":"100","article-title":"Strategies for intranasal delivery of vaccines","volume":"3","author":"M Zaman","year":"2013"},{"key":"ref31","first-page":"148","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"MR Neutra","year":"2006"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.vaccine.2006.07.041","article-title":"Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection","volume":"25","author":"FS Quan","year":"2007","journal-title":"Vaccine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1051\/parasite\/2016012","article-title":"Recombinant Toxoplasma gondii phosphoglycerate mutase 2 confers protective immunity against toxoplasmosis in BALB\/c mice","volume":"23","author":"HL Wang","year":"2016","journal-title":"Parasite"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12396","article-title":"Regulation of germinal center B\u2010cell differentiation","volume":"270","author":"Y Zhang","year":"2016","journal-title":"Immunol Rev"},{"key":"ref35","first-page":"2009","article-title":"Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution","volume":"180","author":"KN Gibson-Corley","year":"2012"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-3024.2008.01066.x","article-title":"Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells","volume":"31","author":"R Stephens","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4049\/jimmunol.167.2.902","article-title":"IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection","volume":"167","author":"LC Gavrilescu","year":"2001","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1128\/JVI.02052-06","article-title":"Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus","volume":"81","author":"FS Quan","year":"2007","journal-title":"J Virol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:24:41Z","timestamp":1588962281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175644"}},"subtitle":[],"editor":[{"given":"Sanjai","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175644","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}