{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:44:44Z","timestamp":1790707484531,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81301940"],"award-info":[{"award-number":["81301940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81571771"],"award-info":[{"award-number":["81571771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0175906","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T13:52:55Z","timestamp":1492437175000},"page":"e0175906","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comprehensive evaluation of ten deformable image registration algorithms for contour propagation between CT and cone-beam CT images in adaptive head &amp; neck radiotherapy"],"prefix":"10.1371","volume":"12","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-2801","authenticated-orcid":true,"given":"Xin","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.radonc.2013.11.010","article-title":"Intensity-modulated radiation therapy for head and neck cancer: systematic review and meta-analysis","volume":"110","author":"GN Marta","year":"2014","journal-title":"Radiother Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0360-3016(03)00405-X","article-title":"Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation","volume":"57","author":"N Lee","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/cncr.28372","article-title":"Improved survival using intensity-modulated radiation therapy in head and neck cancers: a SEER-Medicare analysis","volume":"120","author":"BM Beadle","year":"2014","journal-title":"Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"JL Barker Jr","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ijrobp.2005.07.957","article-title":"Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer","volume":"64","author":"EK Hansen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1088\/0031-9155\/42\/1\/008","article-title":"Adaptive radiation therapy","volume":"42","author":"D Yan","year":"1997","journal-title":"Phys Med Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.semradonc.2009.11.002","article-title":"Adaptive radiotherapy of head and neck cancer","volume":"20","author":"P Castadot","year":"2010","journal-title":"Semin Radiat Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11912-012-0221-4","article-title":"Current progress in adaptive radiation therapy for head and neck cancer","volume":"14","author":"DL Schwartz","year":"2012","journal-title":"Curr Oncol Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/hed.23477","article-title":"Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning","volume":"36","author":"AM Chen","year":"2014","journal-title":"Head Neck"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1088\/0031-9155\/51\/5\/002","article-title":"Automatic re-contouring in 4D radiotherapy","volume":"51","author":"W Lu","year":"2006","journal-title":"Phys Med Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3109\/0284186X.2011.577806","article-title":"Deformable image registration for contour propagation from CT to cone-beam CT scans in radiotherapy of prostate cancer","volume":"50","author":"M Thor","year":"2011","journal-title":"Acta Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1118\/1.3194750","article-title":"Evaluation of nonrigid registration models for interfraction dose accumulation in radiotherapy","volume":"36","author":"G Janssens","year":"2009","journal-title":"Med Phys"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1088\/0031-9155\/57\/17\/5361","article-title":"Evaluation of the deformation and corresponding dosimetric implications in prostate cancer treatment","volume":"57","author":"N Wen","year":"2012","journal-title":"Phys Med Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radonc.2008.04.010","article-title":"Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumors","volume":"89","author":"P Castadot","year":"2008","journal-title":"Radiother Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1748-717X-7-90","article-title":"A multi-institution evaluation of deformable image registration algorithms for automatic organ delineation in adaptive head and neck radiotherapy","volume":"7","author":"N Hardcastle","year":"2012","journal-title":"Radiat Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1148\/radiol.14132871","article-title":"Quality assurance assessment of diagnostic and radiation therapy-simulation CT image registration for head and neck radiation therapy: anatomic region of interest-based comparison of rigid and deformable algorithms","volume":"274","author":"AS Mohamed","year":"2015","journal-title":"Radiology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1118\/1.2975230","article-title":"Feature-based rectal contour propagation from planning CT to cone beam CT","volume":"35","author":"Y Xie","year":"2008","journal-title":"Med Phys"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1118\/1.3555037","article-title":"Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach","volume":"38","author":"S Nithiananthan","year":"2011","journal-title":"Med Phys"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"6807","DOI":"10.1088\/0031-9155\/57\/21\/6807","article-title":"CT to cone-beam CT deformable registration with simultaneous intensity correction","volume":"57","author":"X Zhen","year":"2012","journal-title":"Phys Med Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.media.2013.01.005","article-title":"Joint CT\/CBCT deformable registration and CBCT enhancement for cancer radiotherapy","volume":"17","author":"Y Lou","year":"2013","journal-title":"Med Image Anal"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"017501","DOI":"10.1118\/1.4767757","article-title":"Deformable registration of the inflated and deflated lung in cone-beam CT-guided thoracic surgery: initial investigation of a combined model- and image-driven approach","volume":"40","author":"A Uneri","year":"2013","journal-title":"Med Phys"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"7979","DOI":"10.1088\/0031-9155\/58\/22\/7979","article-title":"Deformable image registration of CT and truncated cone-beam CT for adaptive radiation therapy","volume":"58","author":"X Zhen","year":"2013","journal-title":"Phys Med Biol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"031703","DOI":"10.1118\/1.4864240","article-title":"Toward adaptive radiotherapy for head and neck patients: Feasibility study on using CT-to-CBCT deformable registration for &quot;dose of the day&quot; calculations","volume":"41","author":"C Veiga","year":"2014","journal-title":"Med Phys"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/1748-717X-8-243","article-title":"Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy","volume":"8","author":"N Hardcastle","year":"2013","journal-title":"Radiat Oncol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.ijrobp.2007.01.030","article-title":"Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy","volume":"68","author":"JL Robar","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.ijrobp.2007.10.067","article-title":"Actual dose variation of parotid glands and spinal cord for nasopharyngeal cancer patients during radiotherapy","volume":"70","author":"C Han","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.radonc.2008.07.006","article-title":"Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration","volume":"89","author":"C Lee","year":"2008","journal-title":"Radiother Oncol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.ijrobp.2007.10.063","article-title":"Local anatomic changes in parotid and submandibular glands during radiotherapy for oropharynx cancer and correlation with dose, studied in detail with nonrigid registration","volume":"70","author":"EM Vasquez Osorio","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/lary.20601","article-title":"Radiation-induced volume changes in parotid and submandibular glands in patients with head and neck cancer receiving postoperative radiotherapy: a longitudinal study","volume":"119","author":"ZH Wang","year":"2009","journal-title":"Laryngoscope"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.radonc.2010.03.007","article-title":"Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in pharyngo-laryngeal tumors treated with concomitant chemo-radiation","volume":"95","author":"P Castadot","year":"2010","journal-title":"Radiother Oncol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.radonc.2012.03.013","article-title":"A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients","volume":"104","author":"HC Cheng","year":"2012","journal-title":"Radiother Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/1748-717X-8-279","article-title":"CBCT-based volumetric and dosimetric variation evaluation of volumetric modulated arc radiotherapy in the treatment of nasopharyngeal cancer patients","volume":"8","author":"X Jin","year":"2013","journal-title":"Radiat Oncol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/jrr\/rrt103","article-title":"Developing an adaptive radiation therapy strategy for nasopharyngeal carcinoma","volume":"55","author":"WW Fung","year":"2014","journal-title":"J Radiat Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11547-013-0326-3","article-title":"Head and neck intensity modulated radiotherapy parotid glands: time of re-planning","volume":"119","author":"A Fiorentino","year":"2014","journal-title":"Radiol Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13014-015-0498-1","article-title":"Determining appropriate timing of adaptive radiation therapy for nasopharyngeal carcinoma during intensity-modulated radiation therapy","volume":"10","author":"H Huang","year":"2015","journal-title":"Radiat Oncol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"726268","DOI":"10.1155\/2015\/726268","article-title":"Evaluation of deformable image registration methods for dose monitoring in head and neck radiotherapy","volume":"2015","author":"B Rigaud","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D Slicer as an image computing platform for the Quantitative Imaging Network","volume":"30","author":"A Fedorov","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0004-3702(81)90024-2","article-title":"Determining optical flow","volume":"17","author":"BKP Horn","year":"1981","journal-title":"Artificial Intelligence"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1023\/B:VISI.0000045324.43199.43","article-title":"Lucas\/Kanade Meets Horn\/Schunck: Combining Local and Global Optic Flow Methods","volume":"61","author":"A Bruhn","year":"2005","journal-title":"International Journal of Computer Vision"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1088\/0031-9155\/49\/14\/003","article-title":"Fast free-form deformable registration via calculus of variations","volume":"49","author":"W Lu","year":"2004","journal-title":"Phys Med Biol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S1361-8415(98)80022-4","article-title":"Image matching as a diffusion process: an analogy with Maxwell&apos;s demons","volume":"2","author":"JP Thirion","year":"1998","journal-title":"Med Image Anal"},{"key":"ref42","first-page":"745","article-title":"Spherical demons: fast surface registration","volume":"11","author":"BT Yeo","year":"2008","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.media.2005.03.003","article-title":"Symmetric image registration","volume":"10","author":"P Rogelj","year":"2006","journal-title":"Med Image Anal"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1088\/0031-9155\/50\/12\/011","article-title":"Validation of an accelerated &apos;demons&apos; algorithm for deformable image registration in radiation therapy","volume":"50","author":"H Wang","year":"2005","journal-title":"Phys Med Biol"},{"key":"ref45","unstructured":"Vemuri BC, Ye J, Chen Y, Leonard CM, editors. A level-set based approach to image registration. Mathematical Methods in Biomedical Image Analysis, 2000 Proceedings IEEE Workshop on; 2000 2000."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1118\/1.3521468","article-title":"Technical note: DIRART\u2014A software suite for deformable image registration and adaptive radiotherapy research","volume":"38","author":"D Yang","year":"2011","journal-title":"Med Phys"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"S Klein","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"101701","DOI":"10.1118\/1.4819945","article-title":"Performance of 12 DIR algorithms in low-contrast regions for mass and density conserving deformation","volume":"40","author":"UJ Yeo","year":"2013","journal-title":"Med Phys"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.ijrobp.2007.01.038","article-title":"Automatic delineation of on-line head-and-neck computed tomography images: toward on-line adaptive radiotherapy","volume":"68","author":"T Zhang","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1118\/1.3223631","article-title":"Demons deformable registration for CBCT-guided procedures in the head and neck: convergence and accuracy","volume":"36","author":"S Nithiananthan","year":"2009","journal-title":"Med Phys"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1118\/1.3554647","article-title":"Deformable planning CT to cone-beam CT image registration in head-and-neck cancer","volume":"38","author":"J Hou","year":"2011","journal-title":"Med Phys"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ejmp.2013.09.001","article-title":"Evaluation of the Block Matching deformable registration algorithm in the field of head-and-neck adaptive radiotherapy","volume":"30","author":"S Huger","year":"2014","journal-title":"Phys Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.ijrobp.2005.04.024","article-title":"Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy","volume":"63","author":"M Imura","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1016\/S1470-2045(12)70243-7","article-title":"Real-time tumour tracking in particle therapy: technological developments and future perspectives","volume":"13","author":"M Riboldi","year":"2012","journal-title":"Lancet Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0175906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:53:40Z","timestamp":1540212820000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0175906"}},"subtitle":[],"editor":[{"given":"Qinghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0175906","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]}}}