{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:48:52Z","timestamp":1789984132134,"version":"4.0.1"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R01HL122472"],"award-info":[{"award-number":["5R01HL122472"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16PRE30510006"],"award-info":[{"award-number":["16PRE30510006"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CCTSI\/CTSA","award":["TL1 TR001081"],"award-info":[{"award-number":["TL1 TR001081"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176243","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T19:44:47Z","timestamp":1493322287000},"page":"e0176243","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms"],"prefix":"10.1371","volume":"12","author":[{"given":"Colleen Marie","family":"Bartman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Khailova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koeppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-4669","authenticated-orcid":true,"given":"Tobias","family":"Eckle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"issue":"6650","key":"ref1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/39086","article-title":"Circadian oscillation of a mammalian homologue of the Drosophila period gene","volume":"389","author":"H Tei","year":"1997","journal-title":"Nature"},{"issue":"21","key":"ref2","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1056\/NEJM198511213132103","article-title":"Circadian variation in the frequency of onset of acute myocardial infarction","volume":"313","author":"JE Muller","year":"1985","journal-title":"N Engl J Med"},{"issue":"11","key":"ref3","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/S0002-9149(97)00181-1","article-title":"Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death","volume":"79","author":"MC Cohen","year":"1997","journal-title":"Am J Cardiol"},{"issue":"6","key":"ref4","first-page":"1226","article-title":"Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction","volume":"31","author":"FA Spencer","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm0106-54","article-title":"When the Clock stops ticking, metabolic syndrome explodes","volume":"12","author":"B Staels","year":"2006","journal-title":"Nat Med"},{"issue":"5","key":"ref6","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.neuron.2007.04.031","article-title":"Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism","volume":"54","author":"V Jakubcakova","year":"2007","journal-title":"Neuron"},{"issue":"10","key":"ref7","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nrg2430","article-title":"The genetics of mammalian circadian order and disorder: implications for physiology and disease","volume":"9","author":"JS Takahashi","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"7191","key":"ref8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature06829","article-title":"Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision","volume":"453","author":"AD Guler","year":"2008","journal-title":"Nature"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.33549\/physiolres.930849","article-title":"Photoperiodic regulation of PER1 and PER2 protein expression in rat peripheral tissues","volume":"55","author":"Z Bendova","year":"2006","journal-title":"Physiol Res"},{"issue":"5","key":"ref10","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nm.2728","article-title":"Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia","volume":"18","author":"T Eckle","year":"2012","journal-title":"Nature medicine"},{"issue":"7074","key":"ref11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nature04368","article-title":"Constant darkness is a circadian metabolic signal in mammals","volume":"439","author":"J Zhang","year":"2006","journal-title":"Nature"},{"issue":"3","key":"ref12","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.biocel.2012.12.022","article-title":"Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein","volume":"45","author":"S Bonney","year":"2013","journal-title":"The international journal of biochemistry & cell biology"},{"issue":"4475","key":"ref13","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1126\/science.7434030","article-title":"Light suppresses melatonin secretion in humans","volume":"210","author":"AJ Lewy","year":"1980","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.me.42.020191.001301","article-title":"The cell biology of acute myocardial ischemia","volume":"42","author":"RB Jennings","year":"1991","journal-title":"Annu Rev Med"},{"issue":"2","key":"ref15","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/FJC.0b013e3181e74a14","article-title":"Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation","volume":"56","author":"GD Lopaschuk","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"ref16","first-page":"II299","article-title":"Heat-shock protein 70 mRNA is induced by anaerobic metabolism in rat hearts","volume":"90","author":"T Myrmel","year":"1994","journal-title":"Circulation"},{"issue":"21","key":"ref17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1152\/physiolgenomics.00020.2014","article-title":"miR-21 in ischemia\/reperfusion injury: a double-edged sword?","volume":"46","author":"X Xu","year":"2014","journal-title":"Physiol Genomics"},{"issue":"17","key":"ref18","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1016\/j.febslet.2014.05.067","article-title":"A feedback regulatory loop between HIF-1alpha and miR-21 in response to hypoxia in cardiomyocytes","volume":"588","author":"Y Liu","year":"2014","journal-title":"FEBS Lett"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3892\/ijmm.2015.2076","article-title":"miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR","volume":"35","author":"C Sun","year":"2015","journal-title":"International journal of molecular medicine"},{"issue":"1","key":"ref20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1172\/JCI75852","article-title":"Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways","volume":"125","author":"IG Gomez","year":"2015","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref21","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCRESAHA.108.193250","article-title":"A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70","volume":"104","author":"C Yin","year":"2009","journal-title":"Circ Res"},{"issue":"3","key":"ref22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12265-010-9169-7","article-title":"MicroRNA-21 in cardiovascular disease","volume":"3","author":"Y Cheng","year":"2010","journal-title":"Journal of cardiovascular translational research"},{"issue":"8","key":"ref23","doi-asserted-by":"publisher","first-page":"e71493","DOI":"10.1371\/journal.pone.0071493","article-title":"Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart","volume":"8","author":"S Bonney","year":"2013","journal-title":"PloS one"},{"issue":"6740","key":"ref24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/22118","article-title":"The mPer2 gene encodes a functional component of the mammalian circadian clock","volume":"400","author":"B Zheng","year":"1999","journal-title":"Nature"},{"issue":"25","key":"ref25","doi-asserted-by":"publisher","first-page":"10144","DOI":"10.1073\/pnas.1103735108","article-title":"Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis","volume":"108","author":"X Ma","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref26","doi-asserted-by":"publisher","first-page":"H2533","DOI":"10.1152\/ajpheart.00472.2006","article-title":"Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice","volume":"291","author":"T Eckle","year":"2006","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"50","key":"ref27","doi-asserted-by":"crossref","DOI":"10.3791\/2526","article-title":"Use of a hanging weight system for coronary artery occlusion in mice","author":"T Eckle","year":"2011","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"2","key":"ref28","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1161\/CIRCULATIONAHA.107.758516","article-title":"Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning","volume":"118","author":"T Eckle","year":"2008","journal-title":"Circulation"},{"issue":"12","key":"ref29","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.106.669697","article-title":"Cardioprotection by ecto-5&apos;-nucleotidase (CD73) and A2B adenosine receptors","volume":"115","author":"T Eckle","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"ref30","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1097\/ALN.0b013e318255793c","article-title":"Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury","volume":"116","author":"M Koeppen","year":"2012","journal-title":"Anesthesiology"},{"issue":"16","key":"ref31","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.107.690180","article-title":"CD39\/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia\/reperfusion injury","volume":"116","author":"D Kohler","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"ref32","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.4049\/jimmunol.1402288","article-title":"Differential Tissue-Specific Function of Adora2b in Cardioprotection","volume":"195","author":"SW Seo","year":"2015","journal-title":"Journal of immunology"},{"issue":"1","key":"ref33","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3181\/0612-RM-308","article-title":"Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo","volume":"233","author":"A Redel","year":"2008","journal-title":"Experimental biology and medicine"},{"issue":"5","key":"ref34","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1084\/jem.20030891","article-title":"Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors","volume":"198","author":"HK Eltzschig","year":"2003","journal-title":"J Exp Med"},{"issue":"9","key":"ref35","doi-asserted-by":"publisher","first-page":"e74535","DOI":"10.1371\/journal.pone.0074535","article-title":"Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction","volume":"8","author":"F Zhu","year":"2013","journal-title":"PloS one"},{"issue":"4","key":"ref36","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1177\/1074248412475158","article-title":"A model of hypoxia-reoxygenation on isolated adult mouse cardiomyocytes: characterization, comparison with ischemia-reperfusion, and application to the cardioprotective effect of regular treadmill exercise","volume":"18","author":"L Portal","year":"2013","journal-title":"Journal of cardiovascular pharmacology and therapeutics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cyto.2016.02.007","article-title":"Hypoxia\/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation","volume":"81","author":"JB Xia","year":"2016","journal-title":"Cytokine"},{"issue":"6","key":"ref38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1161\/CIRCRESAHA.113.300226","article-title":"Non-coding RNAs in cardiac remodeling and heart failure","volume":"113","author":"R Kumarswamy","year":"2013","journal-title":"Circ Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.yjmcc.2013.11.015","article-title":"Fibroblasts in myocardial infarction: a role in inflammation and repair","volume":"70","author":"AV Shinde","year":"2014","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"4","key":"ref40","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/j.1460-9568.2006.04613.x","article-title":"Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans","volume":"23","author":"C Cajochen","year":"2006","journal-title":"Eur J Neurosci"},{"issue":"10","key":"ref41","doi-asserted-by":"publisher","first-page":"e75872","DOI":"10.1371\/journal.pone.0075872","article-title":"Ischemic postconditioning-mediated miRNA-21 protects against cardiac ischemia\/reperfusion injury via PTEN\/Akt pathway","volume":"8","author":"Y Tu","year":"2013","journal-title":"PloS one"},{"issue":"2","key":"ref42","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1093\/cvr\/cvw030","article-title":"miR-21 promotes fibrosis in an acute cardiac allograft transplantation model","volume":"110","author":"SK Gupta","year":"2016","journal-title":"Cardiovascular research"},{"issue":"1","key":"ref43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/shk.0b013e318142c5a2","article-title":"The absence of circadian cues during recovery from sepsis modifies pituitary-adrenocortical function and impairs survival","volume":"29","author":"DE Carlson","year":"2008","journal-title":"Shock"},{"key":"ref44","article-title":"Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy","author":"J Brainard","year":"2015","journal-title":"Anesthesiology"},{"issue":"1","key":"ref45","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1210\/jc.2012-2874","article-title":"Exposure to light at night, nocturnal urinary melatonin excretion, and obesity\/dyslipidemia in the elderly: a cross-sectional analysis of the HEIJO-KYO study","volume":"98","author":"K Obayashi","year":"2013","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"45","key":"ref46","doi-asserted-by":"publisher","first-page":"15869","DOI":"10.1073\/pnas.1418570111","article-title":"Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics","volume":"111","author":"ND Kathale","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"ref47","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.1073\/pnas.1501327112","article-title":"Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1","volume":"112","author":"AM Curtis","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.12659\/MSM.897773","article-title":"Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)\/Vascular Endothelial Growth Factor (VEGF) Signal Pathway","volume":"22","author":"F Yang","year":"2016","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"issue":"4","key":"ref49","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1101\/gad.564110","article-title":"The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors","volume":"24","author":"I Schmutz","year":"2010","journal-title":"Genes Dev"},{"issue":"10","key":"ref50","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1128\/MCB.21.10.3436-3444.2001","article-title":"Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells","volume":"21","author":"TN Seagroves","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3892\/mmr.2016.5010","article-title":"MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1alpha-promoted glycolysis in non-small cell lung cancer cells","volume":"13","author":"S Jiang","year":"2016","journal-title":"Molecular medicine reports"},{"issue":"4","key":"ref52","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/ALN.0000000000000567","article-title":"Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes","volume":"122","author":"JM Olson","year":"2015","journal-title":"Anesthesiology"},{"issue":"4","key":"ref53","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1097\/ALN.0000000000000807","article-title":"MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt\/Nitric Oxide Synthase\/Mitochondrial Permeability Transition Pore Pathway","volume":"123","author":"S Qiao","year":"2015","journal-title":"Anesthesiology"},{"issue":"3","key":"ref54","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.yjmcc.2010.10.031","article-title":"A2b adenosine receptors in cardioprotection: timing is everything","volume":"50","author":"C Methner","year":"2011","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"3","key":"ref55","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/cvr\/cvq082","article-title":"Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia\/reperfusion injury via anti-apoptosis through its target PDCD4","volume":"87","author":"Y Cheng","year":"2010","journal-title":"Cardiovascular research"},{"issue":"6","key":"ref56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.7150\/ijms.4514","article-title":"MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis","volume":"9","author":"Y Qin","year":"2012","journal-title":"International journal of medical sciences"},{"issue":"1","key":"ref57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tins.2007.11.002","article-title":"Melanopsin: an exciting photopigment","volume":"31","author":"MW Hankins","year":"2008","journal-title":"Trends in neurosciences"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-244X-11-17","article-title":"Low-intensity blue-enriched white light (750 lux) and standard bright light (10,000 lux) are equally effective in treating SAD. A randomized controlled study","volume":"11","author":"Y Meesters","year":"2011","journal-title":"BMC psychiatry"},{"issue":"1","key":"ref59","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/archpsyc.58.1.69","article-title":"Circadian time of morning light administration and therapeutic response in winter depression","volume":"58","author":"JS Terman","year":"2001","journal-title":"Archives of general psychiatry"},{"issue":"1","key":"ref60","first-page":"3","article-title":"Efficacy of brief, intense light exposure for treatment of winter depression","volume":"26","author":"JS Terman","year":"1990","journal-title":"Psychopharmacology bulletin"},{"issue":"5","key":"ref61","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.genhosppsych.2012.05.003","article-title":"Bright light therapy as an adjunctive treatment with risperidone in patients with delirium: a randomized, open, parallel group study","volume":"34","author":"J Yang","year":"2012","journal-title":"General hospital psychiatry"},{"issue":"24","key":"ref62","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.2174\/1381612821999150709123504","article-title":"Editorial: Health Impact and Management of a Disrupted Circadian Rhythm and Sleep in Critical Illnesses","volume":"21","author":"T Eckle","year":"2015","journal-title":"Current pharmaceutical design"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/sleep\/26.6.695","article-title":"Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance","volume":"26","author":"J Phipps-Nelson","year":"2003","journal-title":"Sleep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:28:22Z","timestamp":1658968102000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176243"}},"subtitle":[],"editor":[{"given":"Meijing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176243","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}