{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:33:45Z","timestamp":1793568825812,"version":"4.5.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176260","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T18:01:21Z","timestamp":1492624881000},"page":"e0176260","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey"],"prefix":"10.1371","volume":"12","author":[{"given":"Hyemin","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Hee","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaejoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Mi","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon-Suk","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"GS Firestein","year":"2003","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/art.1780370408","article-title":"The mortality of rheumatoid arthritis","volume":"37","author":"F Wolfe","year":"1994","journal-title":"Arthritis Rheum"},{"key":"ref3","first-page":"813","article-title":"The Prognosis of Rheumatoid Arthritis. (185 Patients Followed up over 13 Years)","volume":"56","author":"TG Reah","year":"1963","journal-title":"Proc R Soc Med"},{"issue":"Suppl 3","key":"ref4","doi-asserted-by":"publisher","first-page":"iii30","DOI":"10.1136\/ard.2008.098038","article-title":"Why do people with rheumatoid arthritis still die prematurely?","volume":"67","author":"SE Gabriel","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.berh.2011.10.009","article-title":"Co-morbidities in established rheumatoid arthritis","volume":"25","author":"NJ Gullick","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1136\/annrheumdis-2013-204223","article-title":"Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)","volume":"73","author":"M Dougados","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/art.20853","article-title":"Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study","volume":"52","author":"H Maradit-Kremers","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/rheumatology\/kes305","article-title":"The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment","volume":"52","author":"J Listing","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1186\/ar2404","article-title":"A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis","volume":"10","author":"AL Smitten","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/rheumatology\/kes243","article-title":"Traditional cardiovascular risk factors, inflammation and cardiovascular risk in rheumatoid arthritis","volume":"52","author":"KP Liao","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","article-title":"The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"M Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12891-016-1038-3","article-title":"The challenging interplay between rheumatoid arthritis, ageing and comorbidities","volume":"17","author":"M van Onna","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1136\/annrheumdis-2013-204733","article-title":"Impact of a nurse-led programme on comorbidity management and impact of a patient self-assessment of disease activity on the management of rheumatoid arthritis: results of a prospective, multicentre, randomised, controlled trial (COMEDRA)","volume":"74","author":"M Dougados","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1001\/jama.284.8.984","article-title":"Quality of care for patients with rheumatoid arthritis","volume":"284","author":"CH MacLean","year":"2000","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/annrheumdis-2016-209233","article-title":"Points to consider for reporting, screening for and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: a EULAR initiative","volume":"75","author":"A Baillet","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jbspin.2010.07.016","article-title":"Traditional cardiovascular risk factors in rheumatoid arthritis: a meta-analysis","volume":"78","author":"JF Boyer","year":"2011","journal-title":"Joint Bone Spine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1136\/ard.2006.059980","article-title":"Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients?","volume":"67","author":"A Gonzalez","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3899\/jrheum.080404","article-title":"The role of traditional cardiovascular risk factors among patients with rheumatoid arthritis","volume":"36","author":"SR Brady","year":"2009","journal-title":"J Rheumatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1161\/01.CIR.0000054612.26458.B2","article-title":"Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis","volume":"107","author":"DH Solomon","year":"2003","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"R5","DOI":"10.1186\/ar428","article-title":"Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis","volume":"4","author":"PH Dessein","year":"2002","journal-title":"Arthritis Res"},{"key":"ref21","first-page":"2597","article-title":"Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis","volume":"28","author":"SW Jonsson","year":"2001","journal-title":"J Rheumatol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1002\/art.21288","article-title":"Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors","volume":"52","author":"CP Chung","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.7326\/0003-4819-144-4-200602210-00006","article-title":"Preclinical carotid atherosclerosis in patients with rheumatoid arthritis","volume":"144","author":"MJ Roman","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.semarthrit.2011.09.007","article-title":"Korean Observational Study Network for Arthritis (KORONA): establishment of a prospective multicenter cohort for rheumatoid arthritis in South Korea","volume":"41","author":"YK Sung","year":"2012","journal-title":"Semin Arthritis Rheum"},{"issue":"suppl 10","key":"ref25","article-title":"Prevalence of Co-Morbidities and Evaluation of Their Monitoring in Korean Patients with RA: Comparison with the Results of an International, Cross-Sectional Study (COMORA) [abstract]","volume":"67","author":"IA Choi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3109\/03009742.2011.626443","article-title":"Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity","volume":"41","author":"VR da Cunha","year":"2012","journal-title":"Scand J Rheumatol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4082\/kjfm.2016.37.1.44","article-title":"Relationship between Metabolic Syndrome and Rheumatoid Arthritis","volume":"37","author":"SH Lee","year":"2016","journal-title":"Korean J Fam Med"},{"key":"ref28","first-page":"1830","article-title":"Smoking and risk of rheumatoid arthritis","volume":"20","author":"M Heliovaara","year":"1993","journal-title":"J Rheumatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"L Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1136\/ard.2005.041079","article-title":"Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles","volume":"65","author":"SP Linn-Rasker","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/art.27272","article-title":"Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status","volume":"62","author":"SY Bang","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1002\/art.20989","article-title":"New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility","volume":"52","author":"ST du Montcel","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1002\/art.23432","article-title":"The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort","volume":"58","author":"AW Morgan","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1002\/art.20608","article-title":"Increased susceptibility to rheumatoid arthritis in Koreans heterozygous for HLA-DRB1*0405 and *0901","volume":"50","author":"HS Lee","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/rheumatology\/33.8.713","article-title":"HLA class 2 genes in Singaporean Chinese rheumatoid arthritis","volume":"33","author":"SH Chan","year":"1994","journal-title":"Br J Rheumatol"},{"key":"ref36","first-page":"219","article-title":"Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide","volume":"25","author":"T Furuya","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/art.22373","article-title":"The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide","volume":"56","author":"AH van der Helm-van Mil","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.171.2.538","article-title":"Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule","volume":"171","author":"JA Hill","year":"2003","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/art.24245","article-title":"Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations","volume":"60","author":"HS Lee","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s10038-005-0246-8","article-title":"Ethnic differences in allele frequency of autoimmune-disease-associated SNPs","volume":"50","author":"M Mori","year":"2005","journal-title":"J Hum Genet"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1086\/422827","article-title":"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis","volume":"75","author":"AB Begovich","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/art.21536","article-title":"A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans","volume":"54","author":"CP Kang","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ng1206","article-title":"Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis","volume":"34","author":"A Suzuki","year":"2003","journal-title":"Nat Genet"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1002\/art.21636","article-title":"The functional -169T\u2014&gt;C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans","volume":"54","author":"X Hu","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/ng1540","article-title":"A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities","volume":"37","author":"Y Kochi","year":"2005","journal-title":"Nat Genet"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/ng1267","article-title":"An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis","volume":"35","author":"S Tokuhiro","year":"2003","journal-title":"Nat Genet"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1136\/annrheumdis-2013-203323","article-title":"Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies","volume":"73","author":"Z Jin","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1093\/rheumatology\/kes376","article-title":"The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis","volume":"52","author":"IC Scott","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1111\/add.12104","article-title":"Alcohol-a universal preventive agent? A critical analysis","volume":"108","author":"HO Fekjaer","year":"2013","journal-title":"Addiction"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00296-014-3185-x","article-title":"Diet and alcohol as risk factors for rheumatoid arthritis: a nested case-control study","volume":"35","author":"B Sundstrom","year":"2015","journal-title":"Rheumatol Int"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.acvd.2010.03.007","article-title":"High risk of clinical cardiovascular events in rheumatoid arthritis: Levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis","volume":"103","author":"C Meune","year":"2010","journal-title":"Arch Cardiovasc Dis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/art.24836","article-title":"Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study","volume":"61","author":"MJ Peters","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1136\/ard.2010.143396","article-title":"The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study","volume":"70","author":"J Lindhardsen","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1093\/rheumatology\/keu224","article-title":"Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment","volume":"53","author":"E Choy","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"59","author":"JA Avina-Zubieta","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e000267","DOI":"10.1136\/rmdopen-2016-000267","article-title":"Characteristics of rheumatoid arthritis and its association with major comorbid conditions: cross-sectional study of 502 649 UK Biobank participants","volume":"2","author":"S Siebert","year":"2016","journal-title":"RMD Open"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1136\/annrheumdis-2014-205675","article-title":"Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study","volume":"74","author":"A Ogdie","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s13075-015-0728-9","article-title":"Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis","volume":"17","author":"TA Simon","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4143\/crt.2002.34.1.3","article-title":"Epidemiology of Lung Cancer in Korea","volume":"34","author":"CT Lee","year":"2002","journal-title":"Cancer Res Treat"},{"key":"ref60","unstructured":"World Health Organization. WHO reports the incidence rates of active tuberculosis of South Korea in 2015 are 80 per 100,000 population. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/tb\/data\" xlink:type=\"simple\">http:\/\/www.who.int\/tb\/data<\/ext-link>."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3109\/s10165-004-0281-x","article-title":"Clinical characteristics of Mycobacterium tuberculosis infection among rheumatoid arthritis patients","volume":"14","author":"Y Yoshinaga","year":"2004","journal-title":"Mod Rheumatol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1002\/art.21137","article-title":"Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden","volume":"52","author":"J Askling","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.5588\/ijtld.15.0087","article-title":"Increased risk of pulmonary and extra-pulmonary tuberculosis in patients with rheumatic diseases","volume":"19","author":"MC Lu","year":"2015","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.5588\/ijtld.13.0368","article-title":"Risk of tuberculosis in rheumatoid arthritis patients on tumour necrosis factor-alpha inhibitor treatment in Taiwan","volume":"17","author":"WM Ke","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1136\/ard.61.11.968","article-title":"Atopic disorders in ankylosing spondylitis and rheumatoid arthritis","volume":"61","author":"M Rudwaleit","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00296-003-0369-1","article-title":"Prevalence of atopy in rheumatoid arthritis in Sivas, Turkey. A prospective clinical study","volume":"24","author":"E Kaptanoglu","year":"2004","journal-title":"Rheumatol Int"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00296-013-2785-1","article-title":"Lower lifetime prevalence of atopy in rheumatoid arthritis","volume":"34","author":"E Hajdarbegovic","year":"2014","journal-title":"Rheumatol Int"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1067\/mai.2001.119557","article-title":"Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study","volume":"108","author":"J Kero","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1002\/art.1780401203","article-title":"Th1\/Th2 cytokine balance in arthritis","volume":"40","author":"P Miossec","year":"1997","journal-title":"Arthritis Rheum"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4049\/jimmunol.144.2.570","article-title":"IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures","volume":"144","author":"D Vercelli","year":"1990","journal-title":"J Immunol"},{"key":"ref71","first-page":"481","article-title":"Th2-mediated atopic disease protection in Th1-mediated rheumatoid arthritis","volume":"21","author":"AD Hartung","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"ref72","first-page":"5","article-title":"Rheumatoid arthritis and thyroid abnormalities","volume":"49","author":"ND Staykova","year":"2007","journal-title":"Folia Med (Plovdiv)"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/rheumatology\/40.3.353","article-title":"Thyroid disease in systemic lupus erythematosus and rheumatoid arthritis","volume":"40","author":"AT Chan","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/s10165-006-0475-5","article-title":"Disability and patient&apos;s appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan","volume":"16","author":"A Nakajima","year":"2006","journal-title":"Mod Rheumatol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/rheumatology\/35.9.879","article-title":"Prevalence of self-reported depression in patients with rheumatoid arthritis","volume":"35","author":"T Pincus","year":"1996","journal-title":"Br J Rheumatol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2217\/ijr.11.62","article-title":"Depression in patients with rheumatoid arthritis: description, causes and mechanisms","volume":"6","author":"M Margaretten","year":"2011","journal-title":"Int J Clin Rheumtol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"e3551","DOI":"10.1097\/MD.0000000000003551","article-title":"Association of Rheumatoid Arthritis and Hepatitis B Infection: A Nationwide Nested Case-Control Study From 1999 to 2009 in Taiwan","volume":"95","author":"CS Hsu","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1002\/hep.22881","article-title":"Hepatitis B: the virus and disease","volume":"49","author":"TJ Liang","year":"2009","journal-title":"Hepatology"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/ar2480","article-title":"Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations","volume":"10","author":"D Vassilopoulos","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/rheumatology\/41.7.793","article-title":"The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century","volume":"41","author":"D Symmons","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"ref81","first-page":"S295","article-title":"Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis","volume":"18","author":"A Gibofsky","year":"2012","journal-title":"Am J Manag Care"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0178309","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T17:27:54Z","timestamp":1719163674000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176260"}},"subtitle":[],"editor":[{"given":"Shian-Ying","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,19]]},"references-count":81,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176260","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0178309","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,19]]}}}