{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:10:17Z","timestamp":1772043017669,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology (ROC)","award":["MOST105-2311-B-008-003"],"award-info":[{"award-number":["MOST105-2311-B-008-003"]}]},{"DOI":"10.13039\/100015820","name":"Taoyuan General Hospital","doi-asserted-by":"crossref","award":["PTH10227, PTH10310, PTH10327, and PTH10419"],"award-info":[{"award-number":["PTH10227, PTH10310, PTH10327, and PTH10419"]}],"id":[{"id":"10.13039\/100015820","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176377","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T17:28:30Z","timestamp":1492795710000},"page":"e0176377","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Suppressors of cytokine signaling in tuberculosis"],"prefix":"10.1371","volume":"12","author":[{"given":"Shih-Wei","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Mei","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Pin","family":"Chuu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence Shih-Hsin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Hsi","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2567.2001.01236.x","article-title":"The many faces of host responses to tuberculosis","volume":"103","author":"HL Collins","year":"2001","journal-title":"Immunology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev.immunol.19.1.93","article-title":"Immunology of tuberculosis","volume":"19","author":"JL Flynn","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1001\/jama.293.22.2746","article-title":"Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood interferon gamma assay with tuberculin skin testing","volume":"293","author":"M Pai","year":"2005","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.diagmicrobio.2011.09.024","article-title":"Detection of immune cell response to M. tuberculosis-specific antigens by quantitative polymerase chain reaction","volume":"72","author":"I Bibova","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fimmu.2012.00020","article-title":"SOCS, Inflammation, and autoimmunity","volume":"3","author":"A Yoshimura","year":"2012","journal-title":"Front Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2334-13-13","article-title":"Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis","volume":"13","author":"KI Masood","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.jmii.2015.08.018","article-title":"Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis","volume":"49","author":"KI Masood","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"ref8","first-page":"895179","article-title":"Systematic expression profiling analysis identifies specific microRNA-gene interactions that may differentiate between active and latent tuberculosis infection","volume":"2014","author":"LS Wu","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ygcen.2012.06.024","article-title":"Endothelin-1 stimulates suppressor of cytokine signaling-3 gene expression in adipocytes","volume":"178","author":"HH Chang","year":"2012","journal-title":"Gen Comp Endocrinol"},{"key":"ref10","unstructured":"Chang FY, Chou JH, Chuang JH, Chen YH, Liu DP, Chen CH, et al. Taiwan Tuberculosis Control Report 2013. Taipei: Centers for Disease Control, Department of Health, R.O.C (Taiwan); 2014."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1677\/ERC-07-0172","article-title":"Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion","volume":"14","author":"H Neuwirt","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.bbrc.2005.07.057","article-title":"Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells","volume":"335","author":"J Matthews","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.tube.2015.06.002","article-title":"The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis","volume":"95","author":"EI Bini","year":"2015","journal-title":"Tuberculosis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e93831","DOI":"10.1371\/journal.pone.0093831","article-title":"The influence of sex steroid hormones in the immunopathology of experimental pulmonary tuberculosis","volume":"9","author":"EI Bini","year":"2014","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e427","DOI":"10.1371\/journal.pbio.0020427","article-title":"A transcriptional profile of aging in the human kidney","volume":"2","author":"GE Rodwell","year":"2004","journal-title":"PLoS Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.micinf.2014.11.009","article-title":"Increased resistin may suppress reactive oxygen species production and inflammasome activation in type 2 diabetic patients with pulmonary tuberculosis infection","volume":"17","author":"WC Chao","year":"2015","journal-title":"Microbes Infect"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1128\/MCB.25.4.1569-1575.2005","article-title":"Activation of SOCS-3 by resistin","volume":"25","author":"CM Steppan","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e7178","DOI":"10.1371\/journal.pone.0007178","article-title":"SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation","volume":"4","author":"J Hu","year":"2009","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/jid.2009.345","article-title":"Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1","volume":"130","author":"A Linke","year":"2010","journal-title":"J Invest Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e1004134","DOI":"10.1371\/journal.ppat.1004134","article-title":"Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection","volume":"10","author":"L Kedzierski","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"13003","DOI":"10.1073\/pnas.202477099","article-title":"Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation","volume":"99","author":"Y Seki","year":"2002","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1128\/MCB.19.9.6396","article-title":"Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice","volume":"19","author":"A Matsumoto","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"Suppl. 1","key":"ref23","first-page":"3","article-title":"Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis","volume":"17","author":"SW Lee","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"MP Berry","year":"2010","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1365-3083.2012.02731.x","article-title":"SOCS1 gene expression is increased in severe pulmonary tuberculosis","volume":"76","author":"KI Masood","year":"2012","journal-title":"Scand J Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/nri2093","article-title":"SOCS proteins, cytokine signaling and immune regulation","volume":"7","author":"A Yoshimura","year":"2007","journal-title":"Nature Rev Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fimmu.2012.00020","article-title":"SOCS, inflammation, and autoimmunity","volume":"3","author":"A Yoshimura","year":"2012","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2741\/e760","article-title":"SOCS2: physiological and pathological functions","volume":"8","author":"E Letellier","year":"2016","journal-title":"Front Biosci"},{"key":"ref29","first-page":"1","article-title":"SOCS proteins in development and disease","volume":"2","author":"MC Trengove","year":"2013","journal-title":"Am J Clin Exp Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3389\/fimmu.2015.00549","article-title":"Regulation of macrophage, dendritic cell, and microglial phenotype and function by the SOCS proteins","volume":"6","author":"SM McCormick","year":"2015","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ijmm.2016.06.004","article-title":"Monocyte-derived dendritic cells early exposed to Mycobacterium tuberculosis induce an enhanced T helper 17 response and transfer mycobacterial antigens","volume":"306","author":"L Balboa","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"639107","DOI":"10.1155\/2015\/639107","article-title":"Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis","volume":"2015","author":"MV da Silva","year":"2015","journal-title":"J Immunol Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1111\/j.1469-0691.2010.03326.x","article-title":"Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosis TB patients","volume":"17","author":"M Jacobsen","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e92020","DOI":"10.1371\/journal.pone.0092020","article-title":"Genetic contribution of CISH promoter polymorphisms to susceptibility to tuberculosis in Chinese children","volume":"9","author":"L Sun","year":"2014","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"O230","DOI":"10.1111\/1469-0691.12383","article-title":"Differential gene expression of activating Fc\u03b3 receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity","volume":"20","author":"JS Sutherland","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00109-007-0157-6","article-title":"Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis","volume":"85","author":"M Jacobsen","year":"2007","journal-title":"J Mol Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T20:40:35Z","timestamp":1589748035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176377"}},"subtitle":[],"editor":[{"given":"Sunil K","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176377","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,21]]}}}