{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:58:29Z","timestamp":1789153109345,"version":"build-2803163510"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176443","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:34:05Z","timestamp":1493213645000},"page":"e0176443","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats"],"prefix":"10.1371","volume":"12","author":[{"given":"Graeme M.","family":"Doodnaught","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz P.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Edge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Beaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Pelligand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-6043","authenticated-orcid":true,"given":"Paulo","family":"Steagall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/jvim.12346","article-title":"A Review of the Studies Using Buprenorphine in Cats","volume":"28","author":"PVM Steagall","year":"2014","journal-title":"J Vet Intern Med"},{"issue":"1","key":"ref2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1467-2995.2012.00779.x","article-title":"Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats","volume":"40","author":"PV Steagall","year":"2013","journal-title":"Vet Anaesth Analg"},{"issue":"4","key":"ref3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1177\/1098612X15581206","article-title":"Pharmacokinetic and pharmacodynamic evaluation of high doses of buprenorphine delivered via high-concentration formulations in cats","volume":"18","author":"PM Taylor","year":"2016","journal-title":"J Feline Med Surg"},{"issue":"11","key":"ref4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/psp4.12141","article-title":"Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats","volume":"5","author":"L Pelligand","year":"2016","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"issue":"6","key":"ref5","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"C Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/1098612X13477537","article-title":"AAFP and ISFM feline environmental needs guidelines","volume":"15","author":"SL Ellis","year":"2013","journal-title":"J Feline Med Surg"},{"issue":"3","key":"ref7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1053\/rvsc.2001.0543","article-title":"A thermal threshold testing device for evaluation of analgesics in cats","volume":"72","author":"MJ Dixon","year":"2002","journal-title":"Res Vet Sci"},{"issue":"15","key":"ref8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1136\/vr.153.15.462","article-title":"Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine","volume":"153","author":"SA Robertson","year":"2003","journal-title":"Vet Rec"},{"issue":"5","key":"ref9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1365-2885.2005.00677.x","article-title":"PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration","volume":"28","author":"SA Robertson","year":"2005","journal-title":"J Vet Pharmacol Ther"},{"issue":"6","key":"ref10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1467-2995.2005.00275.x","article-title":"Postanesthetic hyperthermia in cats: a retrospective comparison between hydromorphone and buprenorphine","volume":"33","author":"RL Niedfeldt","year":"2006","journal-title":"Vet Anaesth Analg"},{"issue":"6","key":"ref11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1365-2885.2006.00800.x","article-title":"Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats","volume":"29","author":"PVM Steagall","year":"2006","journal-title":"J Vet Pharmacol Ther"},{"issue":"7","key":"ref12","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2460\/ajvr.68.7.699","article-title":"Antinociceptive effects of butorphanol, buprenorphine, or both, administered intramuscularly in cats","volume":"68","author":"JA Johnson","year":"2007","journal-title":"Am J Vet Res"},{"issue":"2","key":"ref13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1467-2995.2009.00519.x","article-title":"Combination of dexmedetomidine with buprenorphine enhances the antinociceptive effect to a thermal stimulus in the cat compared with either agent alone","volume":"37","author":"LS Slingsby","year":"2010","journal-title":"Vet Anaesth Analg"},{"issue":"3","key":"ref14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tvjl.2011.09.008","article-title":"Buprenorphine in combination with naloxone at a ratio of 15:1 does not enhance antinociception from buprenorphine in healthy cats","volume":"192","author":"LS Slingsby","year":"2012","journal-title":"Vet J"},{"issue":"1","key":"ref15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1467-2995.2012.00779.x","article-title":"Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats","volume":"40","author":"PVM Steagall","year":"2013","journal-title":"Vet Anaesth Analg"},{"issue":"3","key":"ref16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/jvp.12084","article-title":"Pharmacokinetics of buprenorphine following intravenous and buccal administration in cats, and effects on thermal threshold","volume":"37","author":"AR Hedges","year":"2014","journal-title":"J Vet Pharmacol Ther"},{"key":"ref17","article-title":"Guidance for Industry: Bioanalytical method validation","year":"2013"},{"issue":"1","key":"ref18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1467-2995.2012.00779.x","article-title":"Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats","volume":"40","author":"PVM Steagall","year":"2013","journal-title":"Vet Anaesth Analg"},{"issue":"6","key":"ref19","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2885.2004.00605.x","article-title":"Plasma clearance","volume":"27","author":"PL Toutain","year":"2004","journal-title":"J Vet Pharmacol Ther"},{"key":"ref20","first-page":"11","article-title":"Pharmacodynamic and pharmacokinetic data analysis: Concepts and Applications","author":"JW Gabrielsson","year":"2006"},{"issue":"3","key":"ref21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/cpt1979253358","article-title":"Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine","volume":"25","author":"LB Sheiner","year":"1979","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"ref22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1365-2885.2007.00931.x","article-title":"Thermal antinociception after dexmedetomidine administration in cats: a dose-finding study","volume":"31","author":"LS Slingsby","year":"2008","journal-title":"J Vet Pharmacol Ther"},{"issue":"3","key":"ref23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/0091270002250613","article-title":"Pharmacokinetic strategies in deciphering atypical drug absorption profiles","volume":"43","author":"H Zhou","year":"2003","journal-title":"J Clin Pharmacol"},{"issue":"6","key":"ref24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10928-012-9275-z","article-title":"A population pharmacokinetic model for the complex systemic absorption of ropivacaine after femoral nerve block in patients undergoing knee surgery","volume":"39","author":"F Gaudreault","year":"2012","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"6","key":"ref25","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1046\/j.1365-2885.2001.368goblin.x","article-title":"Morphine, pethidine and buprenorphine disposition in the cat","volume":"24","author":"PM Taylor","year":"2001","journal-title":"J Vet Pharmacol Ther"},{"issue":"2","key":"ref26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/jvp.12075","article-title":"Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration","volume":"37","author":"AR Hedges","year":"2014","journal-title":"J Vet Pharmacol Ther"},{"issue":"4","key":"ref27","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1467-2995.2011.00613.x","article-title":"Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site","volume":"38","author":"KM Messenger","year":"2011","journal-title":"Vet Anaesth Analg"},{"issue":"9","key":"ref28","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1002\/jps.23492","article-title":"Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship","volume":"102","author":"MW Sadiq","year":"2013","journal-title":"J Pharm Sci"},{"issue":"2","key":"ref29","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1124\/jpet.106.115972","article-title":"Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats","volume":"321","author":"A Yassen","year":"2007","journal-title":"J Pharmacol Exp Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:59:11Z","timestamp":1589734751000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176443"}},"subtitle":[],"editor":[{"given":"Francesco","family":"Staffieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176443","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,26]]}}}