{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:08:37Z","timestamp":1787728117991,"version":"build-2784847793"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.812006592"],"award-info":[{"award-number":["No.812006592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["No. 2014A020211011"],"award-info":[{"award-number":["No. 2014A020211011"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Basal Research Fund for the Medical Young Scientists of Sun Yat-sen University","award":["No. 14ykpy14"],"award-info":[{"award-number":["No. 14ykpy14"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2016A020214012"],"award-info":[{"award-number":["2016A020214012"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["201607010063"],"award-info":[{"award-number":["201607010063"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2014A010105029"],"award-info":[{"award-number":["2014A010105029"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176639","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T19:51:39Z","timestamp":1493322699000},"page":"e0176639","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Corticosteroids effects on LPS-induced rat inflammatory keratocyte cell model"],"prefix":"10.1371","volume":"12","author":[{"given":"Huize","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxia","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/01.ico.0000208815.02120.90","article-title":"Inhibition of inflammatory cytokine production in human corneal cells by dexamethasone, but not cyclosporin","volume":"25","author":"AR Djalilian","year":"2006","journal-title":"Cornea"},{"issue":"6","key":"ref2","first-page":"1327","article-title":"Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappa B","volume":"41","author":"RR Mohan","year":"2000","journal-title":"Invest Ophth Vis Sci"},{"issue":"9","key":"ref3","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1167\/iovs.04-0051","article-title":"Dexamethasone inhibition of IL-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture","volume":"45","author":"Y Lu","year":"2004","journal-title":"Invest Ophth Vis Sci"},{"issue":"3","key":"ref4","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.2353\/ajpath.2007.070172","article-title":"Dexamethasone inhibits interleukin-1 beta-induced corneal neovascularization\u2014Role of nuclear factor-kappa B-activated stromal cells in inflammatory angiogenesis","volume":"171","author":"S Nakao","year":"2007","journal-title":"Am J Pathol"},{"issue":"2","key":"ref5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s10753-015-0299-6","article-title":"Anti-inflammatory Steroid from Phragmitis rhizoma Modulates LPS-Mediated Signaling Through Inhibition of NF-kappa B Pathway","volume":"39","author":"SJ Park","year":"2016","journal-title":"Inflammation"},{"issue":"1","key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19768354.2016.1140676","article-title":"Glucocorticoid-mediated anti-inflammatory effect through NF kappa B is preserved in the absence of Dexras1","volume":"20","author":"JH Yong","year":"2016","journal-title":"Anim Cells Syst"},{"issue":"2","key":"ref7","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ajo.2013.09.025","article-title":"The Steroids for Corneal Ulcers Trial (SCUT): Secondary 12-Month Clinical Outcomes of a Randomized Controlled Trial","volume":"157","author":"M Srinivasan","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"ref8","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/cells2020202","article-title":"Tissue-specific actions of glucocorticoids on apoptosis: a double-edged sword","volume":"2","author":"AL Gruver-Yates","year":"2013","journal-title":"Cells"},{"issue":"6","key":"ref9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1001\/jamaophthalmol.2014.292","article-title":"Early addition of topical corticosteroids in the treatment of bacterial keratitis","volume":"132","author":"KJ Ray","year":"2014","journal-title":"Jama Ophthalmol"},{"key":"ref10","first-page":"179","article-title":"Role of steroids in the treatment of bacterial keratitis","volume":"10","author":"S Palioura","year":"2016","journal-title":"Clin Ophthalmol"},{"issue":"3","key":"ref11","first-page":"384","article-title":"Bacterial spectrum and resistance patterns in corneal infections at a Tertiary Eye Care Center in South China","volume":"9","author":"N Wang","year":"2016","journal-title":"Int J Ophthalmol-Chi"},{"issue":"1","key":"ref12","first-page":"53","article-title":"Corneal infection in Shandong peninsula of China: a 10-year retrospective study on 578 cases","volume":"9","author":"XJ Pan","year":"2016","journal-title":"Int J Ophthalmol-Chi"},{"key":"ref13","first-page":"12","article-title":"Preferred Practice Pattern<sup>\u00ae<\/sup> Guidelines.Bacterial Keratitis-Limited Revision","volume":"2\u20135","year":"1980"},{"issue":"5","key":"ref14","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.ophtha.2016.01.020","article-title":"The Impact Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis","volume":"123","author":"N Carnt","year":"2016","journal-title":"Ophthalmology"},{"issue":"8","key":"ref15","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s00417-016-3412-0","article-title":"Therapeutic dilemma in fungal keratitis: administration of steroids for immune rejection early after keratoplasty","volume":"254","author":"T Wang","year":"2016","journal-title":"Graef Arch Clin Exp"},{"issue":"2","key":"ref16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cyto.2011.07.004","article-title":"Effect of Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells","volume":"56","author":"HJ Choi","year":"2011","journal-title":"Cytokine"},{"issue":"9","key":"ref17","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.1167\/iovs.06-0319","article-title":"Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts","volume":"47","author":"Y Lu","year":"2006","journal-title":"Invest Ophth Vis Sci"},{"issue":"7","key":"ref18","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1167\/iovs.04-1225","article-title":"Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering","volume":"46","author":"JV Jester","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"ref19","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.biocel.2006.03.010","article-title":"The keratocyte: Corneal stromal cell with variable repair phenotypes","volume":"38","author":"JA West-Mays","year":"2006","journal-title":"Int J Biochem Cell B"},{"issue":"Pt 2","key":"ref20","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1042\/bj2740615","article-title":"Relative rates of biosynthesis of collagen type I, type V and type VI in calf cornea","volume":"274","author":"P Kern","year":"1991","journal-title":"The Biochemical journal"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1083\/jcb.103.2.393","article-title":"Type VI collagen in extracellular, 100nm periodic filaments and fibrils identification by immunoelectron microscopy","volume":"103","author":"Romaine R. Bruns","year":"1986","journal-title":"The Journal of cell biology"},{"issue":"2","key":"ref22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0012-1606(86)90013-8","article-title":"Type VI collagen: immunohistochemical identification as a filamentous component of the extracellular matrix of the developing avian corneal stroma","volume":"118","author":"TF Linsenmayer","year":"1986","journal-title":"Developmental biology"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1749-6632.1985.tb51171.x","article-title":"Are collagen fibrils in the developing avian cornea composed of two different collagen types? Evidence from monoclonal antibody studies","volume":"460","author":"TF Linsenmayer","year":"1985","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"6","key":"ref24","first-page":"738","article-title":"Detection of specific collagen types in normal and keratoconus corneas","volume":"10","author":"A David","year":"1981","journal-title":"Invest Ophth Vis Sci"},{"issue":"2","key":"ref25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1006\/excr.1996.0328","article-title":"Collagen VI regulates normal and transformed mesenchymal cell proliferation in vitro","volume":"228","author":"JC Atkinson","year":"1996","journal-title":"Experimental cell research"},{"issue":"4","key":"ref26","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1600-0501.2004.01039.x","article-title":"Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells","volume":"15","author":"D Rothamel","year":"2004","journal-title":"Clin Oral Implan Res"},{"issue":"Pt 3","key":"ref27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1242\/jcs.006064","article-title":"Extracellular matrix dynamics in development and regenerative medicine","volume":"121","author":"WP Daley","year":"2008","journal-title":"J Cell Sci"},{"issue":"2","key":"ref28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1524-475X.2009.00466.x","article-title":"Interactions between extracellular matrix and growth factors in wound healing","volume":"17","author":"GS Schultz","year":"2009","journal-title":"Wound Repair Regen"},{"issue":"2","key":"ref29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.biocel.2008.08.021","article-title":"Evolution of collagen-based adhesion systems","volume":"41","author":"J Heino","year":"2009","journal-title":"Int J Biochem Cell B"},{"issue":"5965","key":"ref30","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1126\/science.1181928","article-title":"Platelets amplify inflammation in arthritis via collagen-dependent microparticle production","volume":"327","author":"E Boilard","year":"2010","journal-title":"Science"},{"issue":"1","key":"ref31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1046\/j.1524-475X.2002.10903.x","article-title":"Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers","volume":"10","author":"GP Ladwig","year":"2002","journal-title":"Wound Repair Regen"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T21:04:50Z","timestamp":1589749490000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176639"}},"subtitle":[],"editor":[{"given":"Fu-Shin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176639","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}