{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:12:49Z","timestamp":1788189169166,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008985","name":"Diab\u00e8te Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008985","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation de l'h\u00f4pital maisonneuve-rosemont"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176650","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T17:40:56Z","timestamp":1493660456000},"page":"e0176650","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-055X","authenticated-orcid":true,"given":"Fran\u00e7ois","family":"Dion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dumayne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Henley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Beauchemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois A.","family":"Leblond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Cartee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pichette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1056\/NEJMcp0906797","article-title":"Clinical practice. Stage IV chronic kidney disease","volume":"362","author":"H Abboud","year":"2010","journal-title":"N Engl J Med"},{"issue":"1","key":"ref2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1743-7075-9-36","article-title":"Exploring metabolic dysfunction in chronic kidney disease","volume":"9","author":"AD Slee","year":"2012","journal-title":"Nutrition & metabolism"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.33549\/physiolres.931128","article-title":"Metabolic disorders in patients with chronic kidney failure","volume":"56","author":"R Cibulka","year":"2007","journal-title":"Physiol Res"},{"issue":"2 Suppl 2","key":"ref4","first-page":"S12","article-title":"KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease","volume":"49","year":"2007","journal-title":"Am J Kidney Dis"},{"issue":"8","key":"ref5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1161\/CIR.0000000000000230","article-title":"Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association","volume":"132","author":"CS Fox","year":"2015","journal-title":"Circulation"},{"issue":"5","key":"ref6","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/ki.2013.497","article-title":"Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study","volume":"85","author":"MA Niewczas","year":"2014","journal-title":"Kidney Int"},{"issue":"6","key":"ref7","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1007\/BF02850219","article-title":"The prevalence of insulin resistance in nondiabetic nonobese patients with chronic kidney disease","volume":"23","author":"D Sit","year":"2006","journal-title":"Adv Ther"},{"issue":"2","key":"ref8","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pcd.2014.05.001","article-title":"Effect of chronic kidney disease on A1C in individuals being screened for diabetes","volume":"9","author":"KE Shipman","year":"2015","journal-title":"Primary care diabetes"},{"issue":"2","key":"ref9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1210\/jc.2014-3313","article-title":"Kidney function, beta-cell function and glucose tolerance in older men","volume":"100","author":"T Jia","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","article-title":"Urea impairs beta cell glycolysis and insulin secretion in chronic kidney disease","author":"L Koppe","year":"2016","journal-title":"The Journal of clinical investigation"},{"key":"ref11","first-page":"691369","article-title":"Insulin resistance in patients with chronic kidney disease","volume":"2012","author":"MT Liao","year":"2012","journal-title":"Journal of biomedicine & biotechnology"},{"issue":"9","key":"ref12","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1093\/ndt\/gft435","article-title":"Insulin resistance in chronic kidney disease: new lessons from experimental models","volume":"29","author":"L Koppe","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"ref13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/j.jrn.2010.11.001","article-title":"Sequence of cellular events in pancreatic islets leading to impaired insulin secretion in chronic kidney disease","volume":"21","author":"SG Massry","year":"2011","journal-title":"J Ren Nutr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000327177","article-title":"Factors determining insulin resistance in chronic hemodialysis patients","volume":"171","author":"AM Hung","year":"2011","journal-title":"Contributions to nephrology"},{"issue":"8","key":"ref15","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1161\/STROKEAHA.115.009861","article-title":"Proteinuria, but Not eGFR, Predicts Stroke Risk in Chronic Kidney Disease: Chronic Renal Insufficiency Cohort Study","volume":"46","author":"DK Sandsmark","year":"2015","journal-title":"Stroke; a journal of cerebral circulation"},{"issue":"6","key":"ref16","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1161\/CIRCULATIONAHA.113.007106","article-title":"Risk of end-stage renal disease and death after cardiovascular events in chronic kidney disease","volume":"130","author":"M Sud","year":"2014","journal-title":"Circulation"},{"issue":"1 Pt 1","key":"ref17","first-page":"E87","article-title":"Muscle insulin resistance in uremic humans: glucose transport, glucose transporters, and insulin receptors","volume":"261","author":"JE Friedman","year":"1991","journal-title":"The American journal of physiology"},{"issue":"8","key":"ref18","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1124\/dmd.111.039115","article-title":"Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats","volume":"39","author":"J Naud","year":"2011","journal-title":"Drug metabolism and disposition: the biological fate of chemicals"},{"issue":"1","key":"ref19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1124\/dmd.107.018192","article-title":"Effects of chronic renal failure on liver drug transporters","volume":"36","author":"J Naud","year":"2008","journal-title":"Drug metabolism and disposition: the biological fate of chemicals"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2005.05.010","article-title":"Effects of renal failure on drug transport and metabolism","volume":"109","author":"H Sun","year":"2006","journal-title":"Pharmacology & therapeutics"},{"issue":"7","key":"ref21","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/ki.2008.691","article-title":"Insulin resistance and altered glucose transporter 4 expression in experimental uremia","volume":"75","author":"D Aksentijevic","year":"2009","journal-title":"Kidney Int"},{"issue":"2 Pt 1","key":"ref22","first-page":"E193","article-title":"Alterations of glucose transporter systems in insulin-resistant uremic rats","volume":"257","author":"DB Jacobs","year":"1989","journal-title":"The American journal of physiology"},{"issue":"1","key":"ref23","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.jrn.2004.09.030","article-title":"Mechanisms of enhanced carbohydrate and lipid metabolism in adipose tissue in uremia","volume":"15","author":"M Szolkiewicz","year":"2005","journal-title":"J Ren Nutr"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1681\/ASN.V122326","article-title":"Downregulation of hepatic cytochrome P450 in chronic renal failure","volume":"12","author":"F Leblond","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"ref25","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1111\/j.1600-6143.2005.00979.x","article-title":"Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats","volume":"5","author":"BH Chung","year":"2005","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"3","key":"ref26","doi-asserted-by":"publisher","first-page":"G13","DOI":"10.1530\/JOE-14-0182","article-title":"Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models","volume":"222","author":"JE Bowe","year":"2014","journal-title":"The Journal of endocrinology"},{"issue":"1","key":"ref27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jep.2011.05.023","article-title":"The efficacy of Prosopis glandulosa as antidiabetic treatment in rat models of diabetes and insulin resistance","volume":"137","author":"C George","year":"2011","journal-title":"Journal of ethnopharmacology"},{"issue":"4","key":"ref28","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1152\/japplphysiol.00631.2011","article-title":"Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not","volume":"111","author":"CM Castorena","year":"2011","journal-title":"Journal of applied physiology (Bethesda, Md: 1985)"},{"issue":"6","key":"ref29","doi-asserted-by":"publisher","first-page":"E966","DOI":"10.1152\/ajpendo.00659.2010","article-title":"Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats","volume":"300","author":"N Sharma","year":"2011","journal-title":"American journal of physiology Endocrinology and metabolism"},{"key":"ref30","article-title":"Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise","author":"H Wang","year":"2015","journal-title":"The journals of gerontology Series A, Biological sciences and medical sciences"},{"issue":"11","key":"ref31","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s11745-002-1004-1","article-title":"31P NMR quantification and monophasic solvent purification of human and bovine lens phospholipids","volume":"37","author":"WC Byrdwell","year":"2002","journal-title":"Lipids"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"OH Lowry","year":"1951","journal-title":"J Biol Chem"},{"issue":"4","key":"ref33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"4 Pt 1","key":"ref34","first-page":"E593","article-title":"Glucose transporter protein content and glucose transport capacity in rat skeletal muscles","volume":"259","author":"EJ Henriksen","year":"1990","journal-title":"The American journal of physiology"},{"issue":"5","key":"ref35","doi-asserted-by":"publisher","first-page":"E818","DOI":"10.1152\/ajpendo.00289.2016","article-title":"Novel single skeletal muscle fiber analysis reveals a fiber type-selective effect of acute exercise on glucose uptake","volume":"311","author":"GD Cartee","year":"2016","journal-title":"American journal of physiology Endocrinology and metabolism"},{"issue":"5","key":"ref36","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1053\/j.ajkd.2008.12.031","article-title":"Glucose control by the kidney: an emerging target in diabetes","volume":"53","author":"O Marsenic","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"ref37","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1097\/01.ASN.0000019900.87535.43","article-title":"Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease","volume":"13","author":"K Shinohara","year":"2002","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"ref38","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1172\/JCI110067","article-title":"Insulin resistance in uremia","volume":"67","author":"RA DeFronzo","year":"1981","journal-title":"The Journal of clinical investigation"},{"issue":"2\u20133","key":"ref39","first-page":"27","article-title":"Pathophysiology of obesity-induced insulin resistance and type 2 diabetes mellitus","volume":"6","author":"PA Tataranni","year":"2002","journal-title":"European review for medical and pharmacological sciences"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"E535","DOI":"10.1152\/ajpendo.2000.278.3.E535","article-title":"Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats","volume":"278","author":"M Nawano","year":"2000","journal-title":"American journal of physiology Endocrinology and metabolism"},{"issue":"11","key":"ref41","doi-asserted-by":"publisher","first-page":"3252","DOI":"10.2337\/diabetes.54.11.3252","article-title":"Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study","volume":"54","author":"MK Rutter","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"ref42","first-page":"255","article-title":"Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus","volume":"18","author":"L Rossetti","year":"1995","journal-title":"Clinical and investigative medicine Medecine clinique et experimentale"},{"issue":"2","key":"ref43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1210\/jcem-54-2-217","article-title":"Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics","volume":"54","author":"H Hidaka","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"ref44","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1463-1326.2010.01235.x","article-title":"Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance","volume":"12","author":"P St-Pierre","year":"2010","journal-title":"Diabetes Obes Metab"},{"issue":"11","key":"ref45","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.2337\/diabetes.49.11.1904","article-title":"Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha","volume":"49","author":"JM Youd","year":"2000","journal-title":"Diabetes"},{"issue":"3","key":"ref46","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3945\/an.112.002089","article-title":"Regulation of hepatic glucose uptake and storage in vivo","volume":"3","author":"MC Moore","year":"2012","journal-title":"Advances in nutrition (Bethesda, Md)"},{"issue":"2","key":"ref47","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2337\/diabetes.49.2.272","article-title":"Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity","volume":"49","author":"A Basu","year":"2000","journal-title":"Diabetes"},{"issue":"1","key":"ref48","first-page":"36","article-title":"Glucose metabolism in non-diabetic and insulin-dependent diabetic subjects with end-stage renal failure","volume":"38","author":"O Schmitz","year":"1991","journal-title":"Danish medical bulletin"},{"issue":"120","key":"ref49","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1038\/ki.2010.510","article-title":"Effect of kidney disease on glucose handling (including genetic defects)","author":"J Calado","year":"2011","journal-title":"Kidney Int Suppl"},{"issue":"3 Suppl","key":"ref50","first-page":"S43","article-title":"Type 2 diabetes and the evolving paradigm in glucose regulation","volume":"19","author":"MA Abdul-Ghani","year":"2013","journal-title":"The American journal of managed care"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1681\/ASN.2015070756","article-title":"Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD","volume":"27","author":"IH de Boer","year":"2016","journal-title":"J Am Soc Nephrol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T02:52:28Z","timestamp":1658976748000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176650"}},"subtitle":[],"editor":[{"given":"Makoto","family":"Kanzaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176650","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}