{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:32:46Z","timestamp":1787509966382,"version":"build-2736575974"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0176776","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T13:25:41Z","timestamp":1493731541000},"page":"e0176776","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The presence of bacterial microcolonies on the maxillary sinus ciliary epithelium in healthy young individuals"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-7535","authenticated-orcid":true,"given":"Monika","family":"Morawska-Kochman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Marycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Jermakow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Nelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Bochnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1111\/j.1462-5822.2009.01323.x","article-title":"Evolving concepts in biofilm infections","volume":"11","author":"L Hall-Stoodley","year":"2009","journal-title":"Cell Microbiol"},{"issue":"5","key":"ref2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.2500\/ajra.2009.23.3376","article-title":"Biofilms and mucosal healing in postsurgical patients with chronic rhinosinusitis","volume":"23","author":"Z Zhang","year":"2009","journal-title":"Am J Rhinol Allergy"},{"issue":"2","key":"ref3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1574-695X.2012.00968.x","article-title":"Towards diagnostic guidelines for biofilm-associated infections","volume":"65","author":"L Hall-Stoodley","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"7","key":"ref4","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1097\/MLG.0b013e31806009b0","article-title":"Confocal scanning laser microscopy evidence of biofilms in patients with chronic rhinosinusitis","volume":"117","author":"AJ Psaltis","year":"2007","journal-title":"Laryngoscope"},{"issue":"3","key":"ref5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000079994","article-title":"Evidence of bacterial biofilms in human chronic sinusitis","volume":"66","author":"J Cryer","year":"2004","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"6","key":"ref6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.otohns.2006.03.001","article-title":"Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis","volume":"134","author":"Z Bendouah","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/01.mlg.0000161346.30752.18","article-title":"Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis","volume":"115","author":"JA Sanclement","year":"2005","journal-title":"Laryngoscope"},{"key":"ref8","first-page":"219","article-title":"Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies","volume":"1","author":"JH Fastenberg","year":"2015","journal-title":"World Journal of Otorhinolaryngology-Head and Neck Surgery"},{"key":"ref9","first-page":"249","article-title":"The bacterial flora of the nasal cavity in healthy young men","volume":"24","author":"S Savolainen","year":"1986","journal-title":"Rhinology"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/JCM.27.12.2736-2743.1989","article-title":"Comparison of the nasal bacterial floras in two groups of healthy subjects and in patients with acute maxillary sinusitis","volume":"27","author":"HR Jousimies-Somer","year":"1989","journal-title":"J J Clin Microbiol"},{"issue":"3","key":"ref11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1288\/00005537-198103000-00004","article-title":"Aerobic and anaerobic bacterial flora of normal maxillary sinuses","volume":"91","author":"I Brook","year":"1981","journal-title":"Laryngoscope"},{"key":"ref12","unstructured":"Gale Encyclopedia of Medicine. S.v. &quot;colonization.&quot; Retrieved November 12, 2016 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/medical-dictionary.thefreedictionary.com\/colonization\" xlink:type=\"simple\">http:\/\/medical-dictionary.thefreedictionary.com\/colonization<\/ext-link>."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.micro.57.030502.090720","article-title":"Bacterial biofilms: an emerging link to disease pathogenesis","volume":"57","author":"MR Parsek","year":"2003","journal-title":"Annu Rev Microbiol"},{"issue":"11","key":"ref14","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1002\/jbm.a.35072","article-title":"The morphology, proliferation rate, and population doubling time factor of adipose-derived mesenchymal stem cells cultured on to non-aqueous SiO2, TiO2, and hybrid sol-gel-derived oxide coatings","volume":"102","author":"K Marycz","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13223-015-0102-0","article-title":"The human microbiome, asthma, and allergy","volume":"11","author":"A Riiser","year":"2015","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3389\/fmicb.2015.01050","article-title":"Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches","volume":"6","author":"JE Beliz\u00e1rio","year":"2015","journal-title":"Front Microbiol"},{"issue":"7164","key":"ref17","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"PJ Turnbaugh","year":"2007","journal-title":"Nature"},{"issue":"5418","key":"ref18","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"JW Costerton","year":"1999","journal-title":"Science."},{"issue":"3","key":"ref19","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jaci.2013.06.049","article-title":"Host-microbial interactions in patients with chronic rhinosinusitis","volume":"133","author":"DL Hamilos","year":"2014","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"5","key":"ref20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3109\/00365549209054650","article-title":"Bacteriology of the maxillary sinus in healthy volunteers","volume":"24","author":"J Sobin","year":"1992","journal-title":"Scand J Infect Dis"},{"issue":"9","key":"ref21","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.tim.2013.06.002","article-title":"The in vivo biofilm","volume":"21","author":"T Bjarnsholt","year":"2013","journal-title":"Trends Microbiol"},{"issue":"3","key":"ref22","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2500\/ajra.2009.23.3317","article-title":"Bacterial flora in normal adult maxillary sinuses","volume":"23","author":"W Abou-Hamad","year":"2009","journal-title":"Am J Rhinol Allergy"},{"issue":"4","key":"ref23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.amjoto.2013.01.001","article-title":"Bacteriology of normal frontal sinuses","volume":"34","author":"S Albu","year":"2013","journal-title":"Am J Otolaryngol"},{"issue":"12","key":"ref24","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/0278-2391(87)90155-8","article-title":"Bacteriology of the maxillary sinus","volume":"45","author":"HE Cook","year":"1987","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1017\/S0022215100145311","article-title":"Bacteriology of endoscopically normal maxillary sinuses","volume":"113","author":"RS Jiang","year":"1999","journal-title":"J Laryngol Otol"},{"issue":"2","key":"ref26","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1749-4486.2010.02097.x","article-title":"A biofilm exists on healthy mucosa of the paranasal sinuses: a prospectively performed, blinded, scanning electron microscope study","volume":"35","author":"R Mladina","year":"2010","journal-title":"Clin Otolaryngol"},{"key":"ref27","first-page":"97","article-title":"EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists","volume":"45","author":"W Fokkens","year":"2007","journal-title":"Rhinology"},{"key":"ref28","first-page":"1685","article-title":"Acute bacterial rhinosinusitis in adults: part I. Evaluation","volume":"70","author":"DC Scheid","year":"2004","journal-title":"Am Fam Physician"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1056\/NEJM197510092931502","article-title":"Sinusitis of the maxillary antrum","volume":"293","author":"FO Evans Jr","year":"1975","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000079994","article-title":"Evidence of bacterial biofilms in human chronic sinusitis","volume":"66","author":"J Cryer","year":"2004","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/194589240501900506","article-title":"Demonstration of biofilm in human bacterial chronic rhinosinusitis","volume":"19","author":"BJ Ferguson","year":"2005","journal-title":"Am J Rhinol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/01.mlg.0000161346.30752.18","article-title":"Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis","volume":"115","author":"JA Sanclement","year":"2005","journal-title":"Laryngoscope"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2500\/ajra.2010.24.3462","article-title":"The impact of biofilms on outcomes after endoscopic sinus surgery","volume":"24","author":"D Singhal","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"ref34","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","year":"1992","journal-title":"MMWR Recomm Rep"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s10096-016-2640-x","article-title":"Microbiology of chronic rhinosinusitis. I","volume":"35","author":"I Brook","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"ref36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.anaerobe.2005.08.002","article-title":"The role of anaerobic bacteria in sinusitis","volume":"12","author":"I Brook","year":"2006","journal-title":"Anaerobe"},{"issue":"1","key":"ref37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1017\/S002221511400303X","article-title":"Bacterial biofilm on the sinus mucosa of healthy subjects and patients with chronic rhinosinusitis (with or without nasal polyposis)","volume":"129","author":"P Singh","year":"2015","journal-title":"J Laryngol Otol"},{"issue":"3","key":"ref38","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/jam.13368","article-title":"Effect of antibiotics on biofilm inhibition and induction measured by real-time cell analysis","volume":"122","author":"M Ferrer","year":"2017","journal-title":"Journal Of Applied Microbiology"},{"issue":"Suppl 11","key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/clr.12637","article-title":"Complex systematic review\u2014Perioperative antibiotics in conjunction with dental implant placement","volume":"26","author":"B Lund","year":"2015","journal-title":"Clinical Oral Implants Research"},{"issue":"4","key":"ref40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ijom.2013.09.013","article-title":"Efficacy of two antibiotic regimens in the reduction of early dental implant failure: a pilot study","volume":"43","author":"K E El-Kholey","year":"2014","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/apm.12099","article-title":"The role of bacterial biofilms in chronic infections","volume":"136","author":"T Bjarnsholt","year":"2013","journal-title":"APMIS Suppl"},{"issue":"12","key":"ref42","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1001\/jamaoto.2013.5465","article-title":"Contrasting the Microbiomes From Healthy Volunteers and Patients With Chronic Rhinosinusitis","volume":"139","author":"R Aurora","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"7","key":"ref43","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/resp.12595","article-title":"Secreted mucins and airway bacterial colonization in non-CF bronchiectasis","volume":"20","author":"O Sibila","year":"2015","journal-title":"Respirology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0176776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:33:19Z","timestamp":1601998399000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0176776"}},"subtitle":[],"editor":[{"given":"Luo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0176776","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]}}}