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Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings 2009 [cited 2016 November 10]. Available from: http:\/\/archive.samhsa.gov\/data\/NSDUH\/2k9NSDUH\/2k9Results.htm<\/ext-link>."},{"key":"ref46","unstructured":"Samuels J, CE. Annual Determination of Average Cost of Incarceration 2015 [cited 2016 July 27]. Available from: https:\/\/www.federalregister.gov\/articles\/2015\/03\/09\/2015-05437\/annual-determination-of-average-cost-of-incarceration<\/ext-link>."},{"key":"ref47","unstructured":"Social Security Administration. Measures Of Central Tendency For Wage Data\u2014Average and Median Amounts of Net Compensation [cited 2016 July 18]. Available from: 7s:\/\/www.ssa.gov\/oact\/cola\/central.html<\/ext-link>."},{"key":"ref48","unstructured":"Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration. Results from the 2015 National Survey on Drug Use and Health: Detailed Tables [cited 2016 November 2]. Available from: http:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-DetTabs-2015\/NSDUH-DetTabs-2015\/NSDUH-DetTabs-2015.pdf<\/ext-link>."},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jp.2015.36","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012","volume":"35","author":"SW Patrick","year":"2015","journal-title":"J Perinatol"},{"key":"ref50","unstructured":"Kilmer B ES, Caulkins JP, et al. What America's Users Spend on Illicit Drugs: 2000 through 2010 2014 [cited 2016 July 29]. Available from: http:\/\/www.rand.org\/pubs\/research_reports\/RR534.html<\/ext-link>."},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1007\/s10620-011-1802-z","article-title":"Direct medical care costs among pegylated interferon plus ribavirin-treated and untreated chronic hepatitis C patients","volume":"56","author":"M Solomon","year":"2011","journal-title":"Dig Dis Sci"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Henrichson C, Delaney R. The Price of Prisons\u2014What Incarceration Costs Taxpayers Center on Setencing and Corrections,; 2012 [updated July 20, 2012; cited 2017 April 3]. Available from: https:\/\/storage.googleapis.com\/vera-web-assets\/downloads\/Publications\/the-price-of-prisons-what-incarceration-costs-taxpayers\/legacy_downloads\/price-of-prisons-updated-version-021914.pdf<\/ext-link>.","DOI":"10.1525\/fsr.2012.25.1.68"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1525\/fsr.2012.25.1.68","article-title":"The Price of Prisons: What Incarceration Costs Taxpayers","author":"CD, R. Henrichson","year":"2012"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1378\/chest.14-0972","article-title":"Total and state-specific medical and absenteeism costs of COPD among adults aged \u2265 18 years in the United States for 2010 and projections through 2020","volume":"147","author":"ES Ford","year":"2015","journal-title":"Chest"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/dc12-2625","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0376-8716(00)00162-9","article-title":"The economic costs of heroin addiction in the United States","volume":"61","author":"TL Mark","year":"2001","journal-title":"Drug Alcohol Depend"},{"key":"ref57","unstructured":"Centers for Disease Control and Prevention\u2014Division of Heart Disease and Stroke Prevention. Part II: Economic Impact Analysis. Cost of Illness: The Second of a Five-Part Series. Available from: http:\/\/www.cdc.gov\/dhdsp\/programs\/spha\/economic_evaluation\/Module_II\/index.htm<\/ext-link>."},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/jamapsychiatry.2014.366","article-title":"The changing face of heroin use in the United States: a retrospective analysis of the past 50 years","volume":"71","author":"TJ Cicero","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/QCO.0000000000000205","article-title":"The hepatitis C revolution part 1: antiviral treatment options","volume":"28","author":"P Thiagarajan","year":"2015","journal-title":"Curr Opin Infect Dis"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/jamapsychiatry.2014.3043","article-title":"Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin","volume":"72","author":"TJ Cicero","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1377\/hlthaff.2016.0448","article-title":"Mandatory Provider Review And Pain Clinic Laws Reduce The Amounts Of Opioids Prescribed And Overdose Death Rates","volume":"35","author":"D Dowell","year":"2016","journal-title":"Health Aff (Millwood)"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/hep.27950","article-title":"Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus","volume":"62","year":"2015","journal-title":"Hepatology"},{"issue":"5","key":"ref63","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/hep.26431","article-title":"Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals","volume":"58","author":"NK Martin","year":"2013","journal-title":"Hepatology"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11904-014-0238-4","article-title":"Reaching the unreached: treatment as prevention as a workable strategy to mitigate HIV and its consequences in high-risk groups","volume":"11","author":"O Ogbuagu","year":"2014","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"10","key":"ref65","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1016\/S2352-3018(15)00129-0","article-title":"Effect of low-threshold methadone maintenance therapy for people who inject drugs on HIV incidence in Vancouver, BC, Canada: an observational cohort study","volume":"2","author":"K Ahamad","year":"2015","journal-title":"Lancet HIV"},{"issue":"Suppl 2","key":"ref66","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1097\/01.aids.0000172879.20628.e1","article-title":"Review of sampling hard-to-reach and hidden populations for HIV surveillance","volume":"19","author":"R Magnani","year":"2005","journal-title":"AIDS"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1525-1446.2012.01027.x","article-title":"Challenges and strategies for research in prisons","volume":"29","author":"ZL Apa","year":"2012","journal-title":"Public Health Nurs"},{"key":"ref68","unstructured":"Ahrnsbrak R KL, and Harter R. 2015 National Survey on Drug Use and Health: Summary of the Effects of the 2015 NSDUH Questonnaire Redesign: Implications for Data Users [cited 2016 November 11]. Available from: http:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-TrendBreak-2015.pdf<\/ext-link>."},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/cid\/civ221","article-title":"Editorial commentary: getting smart in how we pay for HCV drugs: KAOS vs CONTROL","volume":"61","author":"MS Saag","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"6164","key":"ref70","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1126\/science.342.6164.1302","article-title":"Pharmaceuticals. Advocates protest the cost of a hepatitis C cure","volume":"342","author":"J Cohen","year":"2013","journal-title":"Science"},{"key":"ref71","unstructured":"Davidson J. Obama anti-heroin strategy shifts focus to treatment from arrests: Washington Post; 2016 [updated March 29, 2016; cited 2016 July 29]. Available from: https:\/\/www.washingtonpost.com\/news\/powerpost\/wp\/2016\/03\/29\/obama-unveils-anti-heroin-strategy\/<\/ext-link>."},{"key":"ref72","unstructured":"Fact Sheet: Obama Administration Announces Additional Actions to Address the Prescription Opioid Abuse and Heroin Epidemic 2016 [cited 2016 July 29]. 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