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\u010cupi\u0107","year":"1999"},{"issue":"12","key":"ref74","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1016\/j.ces.2010.03.008","article-title":"Improvement of the stoichiometric network analysis for determination of instability conditions of complex nonlinear reaction systems","volume":"65","author":"L Kolar-Ani\u0107","year":"2010","journal-title":"Chemical Engineering Science"},{"key":"ref75","first-page":"111","article-title":"Mathematical Modelling","author":"\u017d \u010cupi\u0107","year":"2011"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1258\/0023677054307033","article-title":"In vivo quantitative assessment of catheter patency in rats","volume":"39","author":"J Yang","year":"2005","journal-title":"Lab Anim"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jat.727","article-title":"A good practice guide to the administration of substances and removal of blood, including routes and volumes","volume":"21","author":"KH Diehl","year":"2001","journal-title":"J Appl Toxicol"},{"key":"ref78","first-page":"387","article-title":"Endocrinology and Metabolism","author":"WL Miller","year":"2001"},{"issue":"1\u20132","key":"ref79","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1076\/apab.110.1.90.899","article-title":"Hypothalamic-pituitary-adrenal function","volume":"110","author":"SL Lightman","year":"2002","journal-title":"Arch Physiol Biochem"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"SM Smith","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0306-4530(97)00099-1","article-title":"Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load","volume":"23","author":"J Schulkin","year":"1998","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0361-9230(01)00638-4","article-title":"Corticosteroid receptors in the brain: gene targeting studies","volume":"57","author":"C Kellendonk","year":"2002","journal-title":"Brain Res Bull"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-3057(02)00791-8","article-title":"Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress","volume":"73","author":"S Makino","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"issue":"12","key":"ref84","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1365-2826.2010.02087.x","article-title":"Encoding and decoding mechanisms of pulsatile hormone secretion","volume":"22","author":"JJ Walker","year":"2010","journal-title":"Journal of neuroendocrinology"},{"issue":"102","key":"ref85","doi-asserted-by":"crossref","first-page":"20140875","DOI":"10.1098\/rsif.2014.0875","article-title":"Rapid intra-adrenal feedback regulation of glucocorticoid synthesis","volume":"12","author":"JJ Walker","year":"2015","journal-title":"Journal of the Royal Society, Interface \/ the Royal Society"},{"article-title":"Numerical Initial Value Problems in Ordinary Differential Equations","year":"1971","author":"CW Gear","key":"ref86"},{"key":"ref87","first-page":"225","article-title":"New Research on Neurosecretory Systems","author":"S Jeli\u0107","year":"2008"},{"issue":"2","key":"ref88","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mbs.2005.06.006","article-title":"Mathematical modeling of the hypothalamic-pituitary-adrenal system activity","volume":"197","author":"S Jeli\u0107","year":"2005","journal-title":"Mathematical biosciences"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/jphysiol.1974.sp010568","article-title":"Stimulation electrically and by acetylcholine of the rat hypothalamus in vitro","volume":"239","author":"MW Bradbury","year":"1974","journal-title":"J Physiol"},{"issue":"43","key":"ref90","doi-asserted-by":"crossref","first-page":"17175","DOI":"10.1021\/jp960785o","article-title":"Predictive value of a model of the Briggs-Rauscher reaction fitted to quenching experiments","volume":"100","author":"V Vukojevi\u0107","year":"1996","journal-title":"Journal of Physical Chemistry"},{"issue":"3","key":"ref91","first-page":"343","article-title":"Individuality and stability of nocturnal secretion patterns for eight hormones in healthy young men","volume":"9","author":"P Schulz","year":"2007","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neubiorev.2015.07.011","article-title":"Evidence for the role of corticotropin-releasing factor in major depressive disorder","volume":"58","author":"RP Waters","year":"2015","journal-title":"Neuroscience and biobehavioral reviews"},{"issue":"5","key":"ref93","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2176\/nmc.45.221","article-title":"Hypothalamic hamartoma","volume":"45","author":"K Arita","year":"2005","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"2","key":"ref94","first-page":"212","article-title":"Hypothalamic hamartoma secreting corticotropin-releasing hormone","volume":"100","author":"JM Voyadzis","year":"2004","journal-title":"Case report. J Neurosurg"},{"issue":"8","key":"ref95","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s00296-013-2750-z","article-title":"Corticosteroid-induced neuropsychiatric disorders: review and contrast with neuropsychiatric lupus","volume":"33","author":"SD Bhangle","year":"2013","journal-title":"Rheumatol Int"},{"issue":"2","key":"ref96","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2012.01.035","article-title":"Corticotrophin-releasing factor inhibits neuromedin U mRNA expressing neuron in the rat hypothalamic paraventricular nucleus in vitro","volume":"511","author":"CP Chu","year":"2012","journal-title":"Neurosci Lett"},{"issue":"2","key":"ref97","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.psyneuen.2010.07.016","article-title":"Patterns of salivary cortisol secretion and responses to daily events in patients with remitted bipolar disorder","volume":"36","author":"R Havermans","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"ref98","article-title":"Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder","volume":"18","author":"GR Fries","year":"2014","journal-title":"The international journal of neuropsychopharmacology \/ official scientific journal of the Collegium Internationale Neuropsychopharmacologicum"},{"key":"ref99","first-page":"1","article-title":"Applications of Steroid in Clinical Practice: A Review","volume":"2012","author":"S Shaikh","year":"2012","journal-title":"International Scholarly Research Notices"},{"issue":"10","key":"ref100","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn2914","article-title":"The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration","volume":"11","author":"SL Lightman","year":"2010","journal-title":"Nat Rev Neurosci"},{"issue":"4613","key":"ref101","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.6603658","article-title":"Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons","volume":"221","author":"JB Aldenhoff","year":"1983","journal-title":"Science"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fncel.2013.00091","article-title":"Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels","volume":"7","author":"S Kratzer","year":"2013","journal-title":"Frontiers in cellular neuroscience"},{"issue":"5","key":"ref103","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01646939","article-title":"Safety and side effects of human and ovine corticotropin-releasing hormone administration in man","volume":"69","author":"M Nink","year":"1991","journal-title":"Klinische Wochenschrift"},{"issue":"1","key":"ref104","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1677\/JOE-09-0363","article-title":"Stress sensitivity is increased in transgenic rats with low brain angiotensinogen","volume":"204","author":"H Muller","year":"2010","journal-title":"The Journal of endocrinology"},{"issue":"1","key":"ref105","doi-asserted-by":"crossref","first-page":"e1000273","DOI":"10.1371\/journal.pcbi.1000273","article-title":"Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction","volume":"5","author":"A Ben-Zvi","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1742-4682-10-65","article-title":"Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring hypercortisolism as an irreversible bistable switch","volume":"10","author":"CA Zarzer","year":"2013","journal-title":"Theor Biol Med Model"},{"key":"ref107","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-0387-0","article-title":"Stochastic Chemical Kinetics: Theory and (Mostly) Systems Biological Applications","author":"P \u00c9rdi","year":"2014"},{"issue":"3","key":"ref108","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/jtbi.2002.3078","article-title":"Stochastic vs. deterministic modeling of intracellular viral kinetics","volume":"218","author":"R Srivastava","year":"2002","journal-title":"Journal of theoretical biology"},{"issue":"8076","key":"ref109","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(78)92467-4","article-title":"Vasopressin in affective illness","volume":"1","author":"PW Gold","year":"1978","journal-title":"Lancet"},{"key":"ref110","article-title":"Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis","author":"EV Sivukhina","year":"2016","journal-title":"Steroids"},{"issue":"5\u20136","key":"ref111","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/FBP.0000000000000049","article-title":"Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin","volume":"25","author":"V Bisagno","year":"2014","journal-title":"Behavioural pharmacology"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.psyneuen.2014.09.009","article-title":"Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females","volume":"51","author":"MQ Steinman","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"ref113","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/jnnp.48.1.50","article-title":"Cerebrospinal fluid vasopressin in neurological and psychiatric disorders","volume":"48","author":"PS Sorensen","year":"1985","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"issue":"5","key":"ref114","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.psyneuen.2007.02.010","article-title":"Lithium, arginine vasopressin and the dex\/CRH test in mood disordered patients","volume":"32","author":"S Watson","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"ref115","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jad.2012.01.025","article-title":"Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features","volume":"138","author":"A Leszczynska-Rodziewicz","year":"2012","journal-title":"J Affect Disord"},{"issue":"6","key":"ref116","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1210\/endo-125-6-2957","article-title":"Modulation of basal and corticotropin-releasing factor-stimulated proopiomelanocortin gene 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