{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:56:41Z","timestamp":1774789001049,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS050596"],"award-info":[{"award-number":["NS050596"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS073930"],"award-info":[{"award-number":["NS073930"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0177610","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T18:57:30Z","timestamp":1494529050000},"page":"e0177610","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation"],"prefix":"10.1371","volume":"12","author":[{"given":"Haifei","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Ji","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-6633","authenticated-orcid":true,"given":"Baoji","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"GP Bates","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"CA Ross","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"issue":"5334","key":"ref5","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"M DiFiglia","year":"1997","journal-title":"Science"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","article-title":"Nuclear and neuropil aggregates in Huntington&apos;s disease: relationship to neuropathology","volume":"19","author":"CA Gutekunst","year":"1999","journal-title":"J Neurosci"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1016\/j.bpj.2010.02.058","article-title":"A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis","volume":"98","author":"G Ossato","year":"2010","journal-title":"Biophys J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnmol.2016.00027","article-title":"Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review","volume":"9","author":"T Zhao","year":"2016","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molcel.2004.06.029","article-title":"Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation","volume":"15","author":"G Schaffar","year":"2004","journal-title":"Mol Cell"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington&apos;s disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"JS Steffan","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1523\/JNEUROSCI.1409-03.2004","article-title":"Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction","volume":"24","author":"ZH Qin","year":"2004","journal-title":"J Neurosci"},{"issue":"5576","key":"ref12","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington&apos;s disease","volume":"296","author":"AW Dunah","year":"2002","journal-title":"Science"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2005-6-12-r100","article-title":"Biased alternative polyadenylation in human tissues","volume":"6","author":"H Zhang","year":"2005","journal-title":"Genome Biol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nrg3482","article-title":"Alternative cleavage and polyadenylation: extent, regulation and function","volume":"14","author":"R Elkon","year":"2013","journal-title":"Nat Rev Genet"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0896-6273(93)90335-O","article-title":"Multiple promoters direct tissue-specific expression of the rat BDNF gene","volume":"10","author":"T Timmusk","year":"1993","journal-title":"Neuron"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2008.05.045","article-title":"Distinct role of long 3&apos; UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons","volume":"134","author":"JJ An","year":"2008","journal-title":"Cell"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2012.05.033","article-title":"Subcellular knockout of importin beta1 perturbs axonal retrograde signaling","volume":"75","author":"RB Perry","year":"2012","journal-title":"Neuron"},{"issue":"5883","key":"ref18","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1155390","article-title":"Proliferating cells express mRNAs with shortened 3&apos; untranslated regions and fewer microRNA target sites","volume":"320","author":"R Sandberg","year":"2008","journal-title":"Science"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2009.06.016","article-title":"Widespread shortening of 3&apos;UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells","volume":"138","author":"C Mayr","year":"2009","journal-title":"Cell"},{"issue":"36","key":"ref20","doi-asserted-by":"crossref","first-page":"15945","DOI":"10.1073\/pnas.1002929107","article-title":"Distinct 3&apos;UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)","volume":"107","author":"AG Lau","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7556","key":"ref21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature14321","article-title":"Alternative 3&apos; UTRs act as scaffolds to regulate membrane protein localization","volume":"522","author":"BD Berkovits","year":"2015","journal-title":"Nature"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nm.2687","article-title":"Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin","volume":"18","author":"GY Liao","year":"2012","journal-title":"Nat Med"},{"issue":"41","key":"ref23","doi-asserted-by":"crossref","first-page":"14318","DOI":"10.1523\/JNEUROSCI.0709-12.2012","article-title":"BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission","volume":"32","author":"EG Waterhouse","year":"2012","journal-title":"J Neurosci"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/hmg\/2.10.1541","article-title":"Differential 3&apos; polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression","volume":"2","author":"B Lin","year":"1993","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/hmg\/3.1.85","article-title":"Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat [corrected]","volume":"3","author":"B Lin","year":"1994","journal-title":"Hum Mol Genet"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nmeth.1319","article-title":"Photoconversion in orange and red fluorescent proteins","volume":"6","author":"GJ Kremers","year":"2009","journal-title":"Nature methods"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"e33093","DOI":"10.1371\/journal.pone.0033093","article-title":"Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma","volume":"7","author":"E Lou","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nprot.2006.37","article-title":"Production and purification of lentiviral vectors","volume":"1","author":"G Tiscornia","year":"2006","journal-title":"Nature protocols"},{"issue":"38","key":"ref29","doi-asserted-by":"crossref","first-page":"27068","DOI":"10.1074\/jbc.M113.486076","article-title":"Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes","volume":"288","author":"K Juenemann","year":"2013","journal-title":"J Biol Chem"},{"issue":"31","key":"ref30","doi-asserted-by":"crossref","first-page":"10871","DOI":"10.1073\/pnas.0802278105","article-title":"Monitoring cellular movement in vivo with photoconvertible fluorescence protein &quot;Kaede&quot; transgenic mice","volume":"105","author":"M Tomura","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"LR Gauthier","year":"2004","journal-title":"Cell"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1471-4159.2009.05992.x","article-title":"Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3&apos; untranslated regions","volume":"109","author":"HA Irier","year":"2009","journal-title":"J Neurochem"},{"issue":"22","key":"ref33","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1093\/nar\/gki1012","article-title":"AU-rich elements and associated factors: are there unifying principles?","volume":"33","author":"C Barreau","year":"2005","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA Translation and Stability by microRNAs","volume":"79","author":"MR Fabian","year":"2010","journal-title":"Annual Review of Biochemistry"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1371\/journal.pcbi.0020043","article-title":"Differential repression of alternative transcripts: a screen for miRNA targets","volume":"2","author":"M Legendre","year":"2006","journal-title":"PLoS computational biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0177610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:00:41Z","timestamp":1588964441000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0177610"}},"subtitle":[],"editor":[{"given":"Hiroyoshi","family":"Ariga","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,11]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0177610","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,11]]}}}