{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:10:10Z","timestamp":1790622610848,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FONDECYT","award":["1150106"],"award-info":[{"award-number":["1150106"]}]},{"name":"FONDECYT","award":["3140357"],"award-info":[{"award-number":["3140357"]}]},{"name":"CARE-PFB","award":["12\/2007"],"award-info":[{"award-number":["12\/2007"]}]},{"DOI":"10.13039\/100006402","name":"ALS Therapy Alliance","doi-asserted-by":"publisher","award":["2014-F-034"],"award-info":[{"award-number":["2014-F-034"]}],"id":[{"id":"10.13039\/100006402","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DRI USA","award":["2013-0030"],"award-info":[{"award-number":["2013-0030"]}]},{"name":"CONICYT","award":["21130854"],"award-info":[{"award-number":["21130854"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0177649","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T18:40:15Z","timestamp":1495132815000},"page":"e0177649","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":127,"title":["ALS skeletal muscle shows enhanced TGF-\u03b2 signaling, fibrosis and induction of fibro\/adipogenic progenitor markers"],"prefix":"10.1371","volume":"12","author":[{"given":"David","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela L.","family":"Rebolledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"van Zundert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-5059","authenticated-orcid":true,"given":"Enrique","family":"Brandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.07.004","article-title":"Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic","volume":"133","author":"R Mancuso","year":"2015","journal-title":"Prog Neurobiol"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s12035-013-8578-4","article-title":"Amyotrophic lateral sclerosis and skeletal muscle: an update","volume":"49","author":"O Pansarasa","year":"2014","journal-title":"Mol Neurobiol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"AE Renton","year":"2011","journal-title":"Neuron"},{"issue":"16","key":"ref4","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1093\/hmg\/ddu136","article-title":"Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis","volume":"23","author":"V Bros-Facer","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"5166","key":"ref5","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"ME Gurney","year":"1994","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5 67 1","DOI":"10.1002\/0471141755.ph0567s69","article-title":"Rodent Models of Amyotrophic Lateral Sclerosis","volume":"69","author":"T Philips","year":"2015","journal-title":"Curr Protoc Pharmacol"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model","volume":"10","author":"FP Di Giorgio","year":"2007","journal-title":"Nat Neurosci"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"M Nagai","year":"2007","journal-title":"Nat Neurosci"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1152\/jn.00500.2012","article-title":"Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability","volume":"109","author":"E Fritz","year":"2013","journal-title":"J Neurophysiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncel.2014.00024","article-title":"Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress","volume":"8","author":"F Rojas","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fncel.2015.00203","article-title":"Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling","volume":"9","author":"F Rojas","year":"2015","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"ref12","first-page":"659","article-title":"SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model","volume":"118","author":"MM Harraz","year":"2008","journal-title":"J Clin Invest"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/glia.20919","article-title":"Extracellular mutant SOD1 induces microglial-mediated motoneuron injury","volume":"58","author":"W Zhao","year":"2010","journal-title":"Glia"},{"issue":"51","key":"ref14","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1073\/pnas.0609411103","article-title":"Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis","volume":"103","author":"TM Miller","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cmet.2008.09.002","article-title":"Skeletal muscle is a primary target of SOD1G93A-mediated toxicity","volume":"8","author":"G Dobrowolny","year":"2008","journal-title":"Cell metabolism"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1093\/hmg\/ddq106","article-title":"Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice","volume":"19","author":"M Wong","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"TA Wynn","year":"2008","journal-title":"J Pathol"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/NEN.0b013e3181e9a34b","article-title":"Targeting fibrosis in Duchenne muscular dystrophy","volume":"69","author":"L Zhou","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"issue":"17","key":"ref19","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1111\/febs.12278","article-title":"Role of proteoglycans in the regulation of the skeletal muscle fibrotic response","volume":"280","author":"E Brandan","year":"2013","journal-title":"The FEBS journal"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12031-007-9023-9","article-title":"Animal models for genetic neuromuscular diseases","volume":"34","author":"M Vainzof","year":"2008","journal-title":"J Mol Neurosci"},{"issue":"17","key":"ref21","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1111\/febs.12267","article-title":"The mdx mouse model as a surrogate for Duchenne muscular dystrophy","volume":"280","author":"TA Partridge","year":"2013","journal-title":"The FEBS journal"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1078\/S0171-9335(04)70020-5","article-title":"Synthesis of proteoglycans is augmented in dystrophic mdx mouse skeletal muscle","volume":"79","author":"S Caceres","year":"2000","journal-title":"Eur J Cell Biol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jcp.21324","article-title":"Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF\/CCN2), which induces their dedifferentiation","volume":"215","author":"C Vial","year":"2008","journal-title":"J Cell Physiol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.phrs.2011.06.002","article-title":"Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice","volume":"64","author":"A Cozzoli","year":"2011","journal-title":"Pharmacol Res"},{"issue":"27","key":"ref25","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1073\/pnas.1204708109","article-title":"Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-beta pathway","volume":"109","author":"A Lorts","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"RD Cohn","year":"2007","journal-title":"Nature medicine"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/hmg\/ddt514","article-title":"Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling","volume":"23","author":"MJ Acu\u00f1a","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2044-5040-4-7","article-title":"Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy","volume":"4","author":"P Pessina","year":"2014","journal-title":"Skeletal muscle"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"965631","DOI":"10.1155\/2014\/965631","article-title":"Understanding the process of fibrosis in Duchenne muscular dystrophy","volume":"2014","author":"Y Kharraz","year":"2014","journal-title":"Biomed Res Int"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.bbamcr.2016.12.020","article-title":"Outside in: The matrix as a modifier of muscular dystrophy","volume":"1864","author":"M Quattrocelli","year":"2017","journal-title":"Biochim Biophys Acta"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"J Massague","year":"1998","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"A Leask","year":"2004","journal-title":"FASEB J"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1034\/j.1600-0404.2002.01301.x","article-title":"Increased plasma TGF-beta1 in patients with amyotrophic lateral sclerosis","volume":"106","author":"K Houi","year":"2002","journal-title":"Acta Neurol Scand"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/cyto.2002.2005","article-title":"Transforming growth factor-Beta 1 (tgf-Beta 1) in patients with amyotrophic lateral sclerosis","volume":"20","author":"J Ilzecka","year":"2002","journal-title":"Cytokine"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2174\/156652411794474356","article-title":"Transforming growth factor-beta signaling in motor neuron diseases","volume":"11","author":"M Katsuno","year":"2011","journal-title":"Curr Mol Med"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.celrep.2015.03.053","article-title":"Astrocyte-derived TGF-beta1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells","volume":"11","author":"F Endo","year":"2015","journal-title":"Cell Rep"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"e0138425","DOI":"10.1371\/journal.pone.0138425","article-title":"Transforming Growth Factor Beta (TGF-beta) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression","volume":"10","author":"Y Si","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"AW Joe","year":"2010","journal-title":"Nature cell biology"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ncb2014","article-title":"Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle","volume":"12","author":"A Uezumi","year":"2010","journal-title":"Nature cell biology"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.057463","article-title":"Connective tissue fibroblasts and Tcf4 regulate myogenesis","volume":"138","author":"SJ Mathew","year":"2011","journal-title":"Development"},{"issue":"17","key":"ref41","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1242\/dev.064162","article-title":"Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration","volume":"138","author":"MM Murphy","year":"2011","journal-title":"Development"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00441-015-2343-0","article-title":"Connective tissue cells expressing fibro\/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis","volume":"364","author":"O Contreras","year":"2016","journal-title":"Cell Tissue Res"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/stem.1082","article-title":"Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration","volume":"30","author":"DR Lemos","year":"2012","journal-title":"Stem cells"},{"issue":"Pt 21","key":"ref44","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1242\/jcs.086629","article-title":"Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle","volume":"124","author":"A Uezumi","year":"2011","journal-title":"J Cell Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fphys.2014.00068","article-title":"Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle","volume":"5","author":"A Uezumi","year":"2014","journal-title":"Front Physiol"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cell.2013.02.053","article-title":"Type 2 innate signals stimulate fibro\/adipogenic progenitors to facilitate muscle regeneration","volume":"153","author":"JE Heredia","year":"2013","journal-title":"Cell"},{"issue":"7632","key":"ref47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nature20160","article-title":"Intronic polyadenylation of PDGFRalpha in resident stem cells attenuates muscle fibrosis","volume":"540","author":"AA Mueller","year":"2016","journal-title":"Nature"},{"issue":"24","key":"ref48","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1093\/hmg\/ddt352","article-title":"Reducing CTGF\/CCN2 slows down mdx muscle dystrophy and improves cell therapy","volume":"22","author":"MG Morales","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"CJ Mann","year":"2011","journal-title":"Skeletal muscle"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00454.2004","article-title":"Inflammatory processes in muscle injury and repair","volume":"288","author":"JG Tidball","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2044-5040-4-6","article-title":"Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis","volume":"4","author":"D Cabrera","year":"2014","journal-title":"Skeletal muscle"},{"key":"ref52","article-title":"Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)","author":"JM Van Dyke","year":"2016","journal-title":"Exp Neurol"},{"issue":"1\u20132","key":"ref53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.nbd.2005.01.010","article-title":"Transforming growth factor-beta 2 causes an acute improvement in the motor performance of transgenic ALS mice","volume":"19","author":"WA Day","year":"2005","journal-title":"Neurobiol Dis"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2044-5040-1-19","article-title":"Role of TGF-beta signaling in inherited and acquired myopathies","volume":"1","author":"TN Burks","year":"2011","journal-title":"Skeletal muscle"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/japplphysiol.01091.2007","article-title":"Transforming growth factor-beta and myostatin signaling in skeletal muscle","volume":"104","author":"HD Kollias","year":"2008","journal-title":"J Appl Physiol"},{"issue":"19","key":"ref56","doi-asserted-by":"crossref","first-page":"18871","DOI":"10.1074\/jbc.M410762200","article-title":"Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1","volume":"280","author":"SL Dallas","year":"2005","journal-title":"J Biol Chem"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/1523-1747.ep12318465","article-title":"Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis","volume":"105","author":"A Igarashi","year":"1995","journal-title":"J Invest Dermatol"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/1523-1747.ep12345771","article-title":"Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders","volume":"106","author":"A Igarashi","year":"1996","journal-title":"J Invest Dermatol"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1523-1755.1998.00820.x","article-title":"Expression of connective tissue growth factor in human renal fibrosis","volume":"53","author":"Y Ito","year":"1998","journal-title":"Kidney Int"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.LAB.0000017365.18894.D3","article-title":"Effects and regulation of connective tissue growth factor on hepatic stellate cells","volume":"82","author":"V Paradis","year":"2002","journal-title":"Lab Invest"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/path.2952","article-title":"CTGF\/CCN-2 overexpression can directly induce features of skeletal muscle dystrophy","volume":"225","author":"G Morales","year":"2011","journal-title":"J Pathol"},{"issue":"17","key":"ref62","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1111\/febs.12370","article-title":"Tissue-resident mesenchymal stem\/progenitor cells in skeletal muscle: collaborators or saboteurs?","volume":"280","author":"RN Judson","year":"2013","journal-title":"The FEBS journal"},{"issue":"7","key":"ref63","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nm.3869","article-title":"Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro\/adipogenic progenitors","volume":"21","author":"DR Lemos","year":"2015","journal-title":"Nature medicine"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ng1922","article-title":"PDGF signaling specificity is mediated through multiple immediate early genes","volume":"39","author":"J Schmahl","year":"2007","journal-title":"Nat Genet"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ng1306","article-title":"Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis","volume":"36","author":"WV Chen","year":"2004","journal-title":"Nat Genet"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.devcel.2008.12.003","article-title":"Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis","volume":"16","author":"LE Olson","year":"2009","journal-title":"Dev Cell"},{"issue":"8","key":"ref67","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.2848","article-title":"Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury","volume":"18","author":"S Dulauroy","year":"2012","journal-title":"Nature medicine"},{"issue":"10","key":"ref68","doi-asserted-by":"crossref","first-page":"e48040","DOI":"10.1371\/journal.pone.0048040","article-title":"Transforming growth factor Beta 3 is required for excisional wound repair in vivo","volume":"7","author":"M Le","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1242\/dmm.013326","article-title":"TGF-beta3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats","volume":"7","author":"Z Chang","year":"2014","journal-title":"Dis Model Mech"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0177649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T22:28:20Z","timestamp":1589754500000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0177649"}},"subtitle":[],"editor":[{"given":"Atsushi","family":"Asakura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":69,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0177649","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}