{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:38:53Z","timestamp":1780051133916,"version":"3.53.1"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background\/Objectives<\/jats:title>\n<jats:p>Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Several patients\u00b4 or procedure related risk factors for post-ERCP pancreatitis (PEP) have been suggested. The aim of this study was to validate the risk factors for PEP in a high-volume center.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>All patients undergoing first time ERCP at a tertiary referral center between December 2010 and October 2013 were retrospectively included. PEP was defined according to the Atlanta Classification.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>404 patients were included in the final analysis. The risk to develop PEP was increased in patients after inadvertent cannulation of the pancreatic duct (odds ratio 7.468 (2.792\u201319.975); p&lt;0.001), which occurred in 37.4% of the patients. Inadvertent cannulation occurred significantly more frequently in patients with difficult cannulation of the papilla duodeni major (odds ratio 7.3; p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Inadvertent cannulation of the pancreatic duct is a procedure related risk factor for PEP. Measurements on preventing inadvertent cannulation of the pancreatic duct should be established and studies on prophylactic measurements should focus particularly on patients with inadvertent cannulation of the pancreatic duct.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0177874","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T19:09:01Z","timestamp":1495134541000},"page":"e0177874","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification of risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis in a high volume center"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-2523","authenticated-orcid":true,"given":"Veit","family":"Phillip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Haf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Alg\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"issue":"8","key":"pone.0177874.ref001","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1111\/j.1572-0241.2007.01279.x","article-title":"Incidence rates of post-ERCP complications: a systematic survey of prospective studies","volume":"102","author":"A Andriulli","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"pone.0177874.ref002","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/MEG.0b013e3283583c6f","article-title":"Quality assessment of endoscopic retrograde cholangiopancreatography: results of a running nationwide Austrian benchmarking project after 5 years of implementation","volume":"24","author":"C Kapral","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"pone.0177874.ref003","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gie.2014.06.045","article-title":"Incidence, severity, and mortality of post-ERCP pancreatitis: a systematic review by using randomized, controlled trials","volume":"81","author":"B Kochar","year":"2015","journal-title":"Gastrointest Endosc"},{"issue":"3","key":"pone.0177874.ref004","first-page":"327","article-title":"Endoscopic sphincterotomy-induced pancreatitis: increased risk associated with nondilated bile ducts and sphincter of Oddi dysfunction","volume":"89","author":"YK Chen","year":"1994","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"pone.0177874.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5107(98)70121-X","article-title":"Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study","volume":"48","author":"S Loperfido","year":"1998","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"pone.0177874.ref006","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00042737-199805000-00012","article-title":"Post-ERCP pancreatitis and hyperamylasaemia: the role of operative and patient factors","volume":"10","author":"RJ Dickinson","year":"1998","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"10","key":"pone.0177874.ref007","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1055\/s-2003-42614","article-title":"Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: a meta-analysis","volume":"35","author":"E Masci","year":"2003","journal-title":"Endoscopy"},{"issue":"4","key":"pone.0177874.ref008","first-page":"1068","article-title":"Complications of endoscopic sphincterotomy. 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