{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:00:41Z","timestamp":1777748441786,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/25177-0"],"award-info":[{"award-number":["2013\/25177-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305245\/2015-5"],"award-info":[{"award-number":["305245\/2015-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0177967","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T18:29:30Z","timestamp":1495477770000},"page":"e0177967","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The gingival vein as a minimally traumatic site for multiple blood sampling in guinea pigs and hamsters"],"prefix":"10.1371","volume":"12","author":[{"given":"Mariana Valotta","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Oliveira","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia Zaccanini","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia Gomes de Moura","family":"Mattaraia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-3757","authenticated-orcid":true,"given":"Marcelo Larami","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,22]]},"reference":[{"key":"ref1","article-title":"Normativas do Concea para produ\u00e7\u00e3o, manuten\u00e7\u00e3o ou utiliza\u00e7\u00e3o de animais em atividades de ensino ou pesquisa cient\u00edfica","year":"2015"},{"key":"ref2","article-title":"Guide for the care and Use of Laboratory Animals","year":"2011"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.provac.2011.10.003","article-title":"Improving animal welfare and reducing animal use for human vaccine potency testing: state of the science and future directions","volume":"5","author":"W Casey","year":"2011","journal-title":"Procedia in Vaccinology"},{"key":"ref4","unstructured":"Russell WMS, Burch RL (1958). The Principles of Humane Experimental Technique."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jat.727","article-title":"A good practice guide to the administration of substances and removal of blood, including routes and volumes","volume":"21","author":"KH Diehl","year":"2001","journal-title":"J Appl Toxicol"},{"key":"ref6","article-title":"Harkness and Wagner&apos;s Biology and Medicine of Rabbits and Rodents","author":"JE Harkness","year":"2010"},{"key":"ref7","first-page":"680","article-title":"Effects of weekly blood collection in C57BL\/6 mice","volume":"50","author":"BM Raabe","year":"2011","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"ref8","first-page":"324","article-title":"The guinea pig as a model of infectious diseases","volume":"58","author":"DJ Padilla-Carlin","year":"2008","journal-title":"Comparative Medicine"},{"key":"ref9","article-title":"Manual for Quality Control of Diphtheria, Tetanus and Pertussis Vaccines","year":"2013"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc12e02s02","article-title":"Hamster model of leptospirosis","author":"DA Haake","year":"2006","journal-title":"Curr Protoc Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00585873","article-title":"Blood-gas analyses of hibernating hamsters and dormice","volume":"366","author":"G Kreienb\u00fchl","year":"1976","journal-title":"Pfl\u00fcgers Archiv-European Journal of Physiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"R476","DOI":"10.1152\/ajpregu.2000.278.2.R476","article-title":"Metabolic control of food intake and estrous cycles in Syrian hamsters. I. Plasma insulin and leptin","volume":"278","author":"JE Schneider","year":"2000","journal-title":"American Journal of Physiology-Regulatory Integrative and Comparative Physiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1874210601004010037","article-title":"Experimental animal models in periodontology: a review","volume":"4","author":"X Struillou","year":"2010","journal-title":"Open Dent J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.3390\/v4123754","article-title":"Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers","volume":"4","author":"V Wahl-Jensen","year":"2012","journal-title":"Viruses"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.antiviral.2012.06.002","article-title":"The Syrian hamster model of hantavirus pulmonary syndrome","volume":"95","author":"D Safronetz","year":"2012","journal-title":"Antiviral Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"504215","DOI":"10.1155\/2012\/504215","article-title":"Hamster and murine models of severe destructive Lyme arthritis","volume":"2012","author":"E Munson","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"ref17","first-page":"904","article-title":"Farmacopeia Brasileira","year":"2010"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1258\/002367798780599866","article-title":"Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guinea pig, ferret and mink","volume":"32","author":"A Hem","year":"1998","journal-title":"Lab Anim"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cvex.2008.03.008","article-title":"An overview of restraint and blood collection techniques in exotic pet practice","volume":"11","author":"SM Dyer","year":"2008","journal-title":"Vet Clin North Am Exot Anim Pract"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1258\/002367793781082449","article-title":"Cannulation of the lateral saphenous vein\u2014a rapid method to gain access to the venous circulation in anaesthetized guinea pigs","volume":"27","author":"R Nau","year":"1993","journal-title":"Lab Anim"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cvex.2004.02.006","article-title":"Guinea pig and chinchilla care and husbandry","volume":"7","author":"TM Donnelly","year":"2004","journal-title":"Vet Clin North Am Exot Anim Pract"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/laban0609-211","article-title":"Efficiency and safety of a technique for drawing blood from the hamster cranial vena cava","volume":"38","author":"MG Picazo","year":"2009","journal-title":"Lab Anim (NY)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1258\/la.2008.007073","article-title":"Blood collection from the sublingual vein in mice and hamsters: a suitable alternative to retrobulbar technique that provides large volumes and minimizes tissue damage","volume":"43","author":"M Heimann","year":"2009","journal-title":"Lab Anim"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0107s73","article-title":"Blood collection","author":"J Donovan","year":"2006","journal-title":"Curr Protoc Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/laban.787","article-title":"Blood collection in the guinea pig (<italic>Cavia porcellus<\/italic>)","volume":"44","author":"WR Williams","year":"2015","journal-title":"Lab Anim (NY)"},{"key":"ref26","first-page":"56","article-title":"Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of guinea pigs","volume":"47","author":"V Dang","year":"2008","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1098-2337(1984)10:4<285::AID-AB2480100402>3.0.CO;2-8","article-title":"Short-term effects of residence on the testosterone responses to fighting in alpha-male guinea-pigs","volume":"10","author":"N Sachser","year":"1984","journal-title":"Aggressive Behavior"},{"key":"ref28","first-page":"70","article-title":"Repetitive blood sampling from guinea pigs (<italic>Cavia porcellus<\/italic>)","volume":"33","author":"LP Bullock","year":"1983","journal-title":"Lab Anim Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.jepm.2009.04.002","article-title":"Blood collection techniques in exotic small mammals","volume":"18","author":"JO Joslin","year":"2009","journal-title":"Journal of Exotic Pet Medicine"},{"key":"ref30","first-page":"e51982","article-title":"Non-terminal blood sampling techniques in guinea pigs","author":"MM Birck","year":"2014","journal-title":"J Vis Exp"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7883\/yoken.JJID.2002.27","article-title":"Minimally invasive method for collection of blood from guinea pigs","volume":"55","author":"M Keino","year":"2002","journal-title":"Jpn J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jn\/100.1.37","article-title":"Interrelationship of dietary magnesium and potassium in the guinea pig","volume":"100","author":"ND Grace","year":"1970","journal-title":"J Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jps.2600720841","article-title":"Simplified method for intravenous dosing and serial blood sampling of unanesthetized guinea pig","volume":"72","author":"D Hochman","year":"1983","journal-title":"J Pharm Sci"},{"key":"ref34","first-page":"57","article-title":"The laboratory rabbit, guinea pig, hamster, and other rodents","author":"IM Washington","year":"2012"},{"key":"ref35","unstructured":"National Centre for the Replacement Refinement &amp; Reduction of Animals in Research (NC3Rs) (2017). Retro-orbital <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.nc3rs.org.uk\/hamster-retro-orbital-non-surgicalterminal\" xlink:type=\"simple\">https:\/\/www.nc3rs.org.uk\/hamster-retro-orbital-non-surgicalterminal<\/ext-link>"},{"key":"ref36","first-page":"109","article-title":"Gingival vein punction: a new simple technique for drug administration or blood sampling in rats and mice","volume":"36","author":"DT Oliveira","year":"2009","journal-title":"Scand J Lab Anim Sci"},{"key":"ref37","unstructured":"Santoro ML, Mattaraia VGM. Estudo histol\u00f3gico comparativo da vasculatura gengival dos dentes incisivos inferiores de ratos, cobaias e hamsters; 2014; Porto Alegre-RS, Brazil."},{"key":"ref38","first-page":"432","article-title":"Handbook of Laboratory Animal Management and Welfare","author":"S Wolfensohn","year":"2003"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1160\/TH04-02-0120","article-title":"Platelet dysfunction during <italic>Bothrops jararaca<\/italic> snake envenomation in rabbits","volume":"92","author":"ML Santoro","year":"2004","journal-title":"Thromb Haemost"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/path.1700900124","article-title":"The identification of platelets and platelet antigens in histological sections","volume":"90","author":"KC Carstairs","year":"1965","journal-title":"J Pathol Bacteriol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/laban.911","article-title":"Blood profiles in unanesthetized and anesthetized guinea pigs (<italic>Cavia porcellus<\/italic>)","volume":"45","author":"WR Williams","year":"2016","journal-title":"Lab Anim (NY)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0049-3848(86)90290-2","article-title":"Anesthetics and anticoagulants used in the preparation of rat platelet-rich plasma alter rat platelet aggregation","volume":"42","author":"SD Dwyer","year":"1986","journal-title":"Thromb Res"},{"key":"ref43","first-page":"304","article-title":"Laboratory Animal Anaesthesia","author":"P Flecknell","year":"2009"},{"key":"ref44","unstructured":"FELASA Working Group on Pain and Distress:, Baumans V, Brain PF, Brugere H, Clausing P, Jeneskog T, et al. (1994). Pain and distress in laboratory rodents and lagomorphs. Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Pain and Distress accepted by the FELASA Board of Management November 1992. Lab Anim 28: 97\u2013112."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e0161941","DOI":"10.1371\/journal.pone.0161941","article-title":"Evaluation of using behavioural changes to assess post-operative pain in the guinea pig (<italic>Cavia porcellus<\/italic>)","volume":"11","author":"Y Ellen","year":"2016","journal-title":"PLoS One"},{"key":"ref46","first-page":"293","article-title":"Clinical and clinicopathological assessment of serial phlebotomy in the Sprague Dawley rat","volume":"47","author":"RL Scipioni","year":"1997","journal-title":"Lab Anim Sci"},{"key":"ref47","first-page":"1206","article-title":"Schalm&apos;s veterinary hematology","author":"DJ Weiss","year":"2010"},{"key":"ref48","first-page":"185","article-title":"The Golden Hamster: its biology and use in medical research","author":"RG Desai","year":"1968"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1152\/ajplegacy.1961.200.5.1018","article-title":"Age changes in blood of the golden hamster","volume":"200","author":"EL House","year":"1961","journal-title":"Am J Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3181\/00379727-60-15173","article-title":"Changes in erythrocytes of hamsters following castration, splenectomy, and subsequent liver, iron and testosterone injections","volume":"60","author":"KF Stein","year":"1945","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.80.3.189","article-title":"Hematological findings in the golden gamster (<italic>Cricetus auratus<\/italic>)","volume":"80","author":"MO Stewart","year":"1944","journal-title":"J Exp Med"},{"key":"ref52","first-page":"81","article-title":"Effects of weekly blood collection in male and female cynomolgus macaques (<italic>Macaca fascicularis<\/italic>)","volume":"53","author":"CR Adams","year":"2014","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"ref53","first-page":"322","article-title":"Blood collection by gingival puncture on hamsters reduces animal number in leptospirosis virulence tests","volume":"33","author":"C Barbosa da Silva","year":"2016","journal-title":"ALTEX"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0177967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T18:58:58Z","timestamp":1750273138000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0177967"}},"subtitle":[],"editor":[{"given":"Sanjay B","family":"Jadhao","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,22]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0177967","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,22]]}}}