{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:28Z","timestamp":1792167748598,"version":"4.4.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0177998","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:34:54Z","timestamp":1495733694000},"page":"e0177998","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats"],"prefix":"10.1371","volume":"12","author":[{"given":"Laura","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bravo-Osuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Lax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Arranz-Romera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Maneu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Esteban-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"Puebla-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Herrero-Vanrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-5710","authenticated-orcid":true,"given":"Nicol\u00e1s","family":"Cuenca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"issue":"6256","key":"ref1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/343364a0","article-title":"A point mutation of the rhodopsin gene in one form of retinitis pigmentosa","volume":"343","author":"TP Dryja","year":"1990","journal-title":"Nature"},{"key":"ref2","article-title":"'RetinoGenetics': a comprehensive mutation database for genes related to inherited retinal degeneration","volume":"2014","author":"X Ran","year":"2014","journal-title":"Database (Oxford)"},{"issue":"20","key":"ref3","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1021\/bi00186a011","article-title":"Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa","volume":"33","author":"S Kaushal","year":"1994","journal-title":"Biochemistry"},{"issue":"9549","key":"ref4","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"DT Hartong","year":"2006","journal-title":"Lancet"},{"issue":"37","key":"ref5","doi-asserted-by":"crossref","first-page":"34150","DOI":"10.1074\/jbc.M204955200","article-title":"A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system","volume":"277","author":"ME Illing","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"RE Marc","year":"2003","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.exer.2005.03.006","article-title":"Retinal remodeling during retinal degeneration","volume":"81","author":"BW Jones","year":"2005","journal-title":"Exp Eye Res"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10384-012-0147-2","article-title":"Retinal remodeling","volume":"56","author":"BW Jones","year":"2012","journal-title":"Jpn J Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","article-title":"Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases","volume":"43","author":"N Cuenca","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-014-0186-3","article-title":"Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects","volume":"11","author":"A Noailles","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"11\u201312","key":"ref11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1139\/o94-066","article-title":"Apoptosis, retinitis pigmentosa, and degeneration","volume":"72","author":"P Wong","year":"1994","journal-title":"Biochem Cell Biol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1073\/pnas.91.3.974","article-title":"Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa","volume":"91","author":"C Portera-Cailliau","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1350-9462(98)00009-3","article-title":"Apoptotic cell death in retinal degenerations","volume":"17","author":"CE Reme","year":"1998","journal-title":"Prog Retin Eye Res"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1167\/iovs.05-0248","article-title":"Activation of multiple pathways during photoreceptor apoptosis in the rd mouse","volume":"46","author":"F Doonan","year":"2005","journal-title":"Investigative ophthalmology & visual science"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"13875","DOI":"10.3390\/molecules200813875","article-title":"Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration","volume":"20","author":"L Fernandez-Sanchez","year":"2015","journal-title":"Molecules"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12035-008-8045-9","article-title":"Photoreceptor cell death mechanisms in inherited retinal degeneration","volume":"38","author":"J Sancho-Pelluz","year":"2008","journal-title":"Mol Neurobiol"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"e22181","DOI":"10.1371\/journal.pone.0022181","article-title":"Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats","volume":"6","author":"J Kaur","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"e112142","DOI":"10.1371\/journal.pone.0112142","article-title":"Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration","volume":"9","author":"B Arango-Gonzalez","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroscience.2004.04.042","article-title":"Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina","volume":"127","author":"N Cuenca","year":"2004","journal-title":"Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-1-4419-1399-9_60","article-title":"Functional changes in inner retinal neurons in animal models of photoreceptor degeneration","volume":"664","author":"T Puthussery","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2009.12.025","article-title":"Late histological and functional changes in the P23H rat retina after photoreceptor loss","volume":"38","author":"B Kolomiets","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref22","article-title":"Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina","author":"D Garcia-Ayuso","year":"2010","journal-title":"Exp Eye Res"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1167\/iovs.13-12120","article-title":"Impairment of intrinsically photosensitive retinal ganglion cells associated with late stages of retinal degeneration","volume":"54","author":"G Esquiva","year":"2013","journal-title":"Investigative ophthalmology & visual science"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1167\/iovs.15-16808","article-title":"Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a","volume":"56","author":"D Garcia-Ayuso","year":"2015","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref25","first-page":"1706","article-title":"Tool from ancient pharmacopoeia prevents vision loss","volume":"12","author":"JH Boatright","year":"2006","journal-title":"Molecular vision"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e24245","DOI":"10.1371\/journal.pone.0024245","article-title":"Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment","volume":"6","author":"D Mantopoulos","year":"2011","journal-title":"PloS one"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuroscience.2013.08.053","article-title":"Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose","volume":"253","author":"JM Gaspar","year":"2013","journal-title":"Neuroscience"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1471-4159.2010.07092.x","article-title":"Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration","volume":"116","author":"BC Oveson","year":"2011","journal-title":"J Neurochem"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1167\/iovs.11-7496","article-title":"Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23","volume":"52","author":"L Fernandez-Sanchez","year":"2011","journal-title":"H rats. Investigative ophthalmology & visual science"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1167\/iovs.07-1012","article-title":"Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30","volume":"49","author":"MJ Phillips","year":"2008","journal-title":"Investigative ophthalmology & visual science"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1167\/iovs.11-8544","article-title":"TUDCA slows retinal degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice","volume":"53","author":"AV Drack","year":"2012","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/978-3-319-17121-0_57","article-title":"Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice","volume":"854","author":"EC Lawson","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12177-009-9030-x","article-title":"Bile acids in treatment of ocular disease","volume":"2","author":"JH Boatright","year":"2009","journal-title":"J Ocul Biol Dis Infor"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1167\/iovs.12-9851","article-title":"Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis","volume":"53","author":"T Zhang","year":"2012","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/978-1-4614-3209-8_99","article-title":"Pathophysilogical mechanism and treatment strategies for Leber congenital amaurosis","volume":"801","author":"Y Fu","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"e0137826","DOI":"10.1371\/journal.pone.0137826","article-title":"Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration","volume":"10","author":"V Gomez-Vicente","year":"2015","journal-title":"PLoS One"},{"issue":"16","key":"ref37","doi-asserted-by":"crossref","first-page":"10671","DOI":"10.1073\/pnas.162362299","article-title":"Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease","volume":"99","author":"CD Keene","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3727\/096020198389960","article-title":"Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease","volume":"11","author":"WM Duan","year":"2002","journal-title":"Cell Transplant"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12035-012-8295-4","article-title":"Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease","volume":"46","author":"M Castro-Caldas","year":"2012","journal-title":"Mol Neurobiol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s00018-009-8746-x","article-title":"Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells","volume":"66","author":"RJ Viana","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref41","article-title":"Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis","author":"AE Elia","year":"2015","journal-title":"Eur J Neurol"},{"issue":"15","key":"ref42","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.1128\/JVI.01165-15","article-title":"Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease","volume":"89","author":"LM Cortez","year":"2015","journal-title":"J Virol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"R Gaudana","year":"2010","journal-title":"AAPS J"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrd4363","article-title":"Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies","volume":"13","author":"S Mitragotri","year":"2014","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0169-409X(01)00200-9","article-title":"Biodegradable microspheres for vitreoretinal drug delivery","volume":"52","author":"R Herrero-Vanrell","year":"2001","journal-title":"Advanced drug delivery reviews"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.preteyeres.2004.02.003","article-title":"Drug delivery systems for vitreoretinal diseases","volume":"23","author":"T Yasukawa","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"ref47","first-page":"1783","article-title":"Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma","volume":"13","author":"C Jiang","year":"2007","journal-title":"Molecular vision"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2011.06.023","article-title":"Retinal ganglion cells survival in a glaucoma model by GDNF\/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure","volume":"156","author":"P Checa-Casalengua","year":"2011","journal-title":"J Control Release"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2013.01.007","article-title":"Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation","volume":"167","author":"SR Chennamaneni","year":"2013","journal-title":"J Control Release"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.preteyeres.2014.04.002","article-title":"The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies","volume":"42","author":"R Herrero-Vanrell","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2015.05.279","article-title":"Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology","volume":"211","author":"V Andres-Guerrero","year":"2015","journal-title":"J Control Release"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1023\/A:1015841715384","article-title":"Controlled delivery systems for proteins based on poly(lactic\/glycolic acid) microspheres","volume":"8","author":"S Cohen","year":"1991","journal-title":"Pharm Res"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0142-9612(90)90018-L","article-title":"Macromolecules released from polymers: diffusion into unstirred fluids","volume":"11","author":"ML Radomsky","year":"1990","journal-title":"Biomaterials"},{"issue":"14","key":"ref54","first-page":"3251","article-title":"Encapsulated Tudca Plga Microspheres For The Treatment Of Retinitis Pigmentosa","volume":"52","author":"R Herrero-Vanrell","year":"2011","journal-title":"Investigative ophthalmology & visual science"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier","volume":"3","author":"HK Makadia","year":"2011","journal-title":"Polymers (Basel)"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1517\/17425247.2010.498817","article-title":"Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis","volume":"7","author":"F Paganelli","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.exer.2015.10.012","article-title":"Long time remodeling during retinal degeneration evaluated by optical coherence tomography, immunocytochemistry and fundus autofluorescence","volume":"150","author":"I Pinilla","year":"2016","journal-title":"Exp Eye Res"},{"issue":"8","key":"ref58","doi-asserted-by":"crossref","first-page":"e43074","DOI":"10.1371\/journal.pone.0043074","article-title":"Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats","volume":"7","author":"L Fernandez-Sanchez","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"ref59","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1167\/iovs.03-0072","article-title":"Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6","volume":"44","author":"H Zhang","year":"2003","journal-title":"Investigative ophthalmology & visual science"},{"issue":"12","key":"ref60","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1089\/hum.2012.067","article-title":"Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa","volume":"23","author":"L Fernandez-Sanchez","year":"2012","journal-title":"Hum Gene Ther"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0896-6273(00)00159-8","article-title":"RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function","volume":"28","author":"F Schmitz","year":"2000","journal-title":"Neuron"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2006.01.111","article-title":"Distribution of vesicular glutamate transporters in rat and human retina","volume":"1082","author":"J Gong","year":"2006","journal-title":"Brain Res"},{"issue":"9","key":"ref63","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1167\/iovs.14-14421","article-title":"Loss of outer retinal neurons and circuitry alterations in the DBA\/2J mouse","volume":"55","author":"L Fernandez-Sanchez","year":"2014","journal-title":"Investigative ophthalmology & visual science"},{"issue":"10","key":"ref64","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/cne.23751","article-title":"Expression and cellular localization of the voltage-gated calcium channel alpha2delta3 in the rodent retina","volume":"523","author":"L Perez de Sevilla Muller","year":"2015","journal-title":"J Comp Neurol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-079X.2010.00827.x","article-title":"Circadian dysfunction in P23H rhodopsin transgenic rats: effects of exogenous melatonin","volume":"50","author":"P Lax","year":"2011","journal-title":"J Pineal Res"},{"issue":"1\u20132","key":"ref66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2006.10.036","article-title":"Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres","volume":"334","author":"S Mao","year":"2007","journal-title":"Int J Pharm"},{"issue":"3","key":"ref67","first-page":"665","article-title":"Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus","volume":"38","author":"AA Veloso Jr.","year":"1997","journal-title":"Investigative ophthalmology & visual science"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3109\/02713689508995797","article-title":"Biodegradation and tissue reaction to intravitreous biodegradable poly(D,L-lactic-co-glycolic)acid microspheres","volume":"14","author":"GG Giordano","year":"1995","journal-title":"Current eye research"},{"issue":"3","key":"ref69","first-page":"175","article-title":"Clearance of sodium fluorescein incorporated into microspheres from the vitreous after intravitreal injection","volume":"22","author":"B Khoobehi","year":"1991","journal-title":"Ophthalmic surgery"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2147\/IJN.S64100","article-title":"Safety evaluation of poly(lactic-co-glycolic acid)\/poly(lactic-acid) microspheres through intravitreal injection in rabbits","volume":"9","author":"X Rong","year":"2014","journal-title":"International journal of nanomedicine"},{"issue":"Pt B","key":"ref71","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejpb.2015.01.026","article-title":"Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration","volume":"95","author":"G Abrego","year":"2015","journal-title":"European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV"},{"issue":"10","key":"ref72","first-page":"3200","article-title":"P23H rhodopsin transgenic rat: correlation of retinal function with histopathology","volume":"41","author":"S Machida","year":"2000","journal-title":"Investigative ophthalmology & visual science"},{"issue":"1\u20132","key":"ref73","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2005.02.055","article-title":"Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation","volume":"382","author":"I Pinilla","year":"2005","journal-title":"Neurosci Lett"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"B Chang","year":"2002","journal-title":"Vision Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0177998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:27:02Z","timestamp":1719224822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0177998"}},"subtitle":[],"editor":[{"given":"Alfred S.","family":"Lewin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":74,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0177998","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]}}}