{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:09:23Z","timestamp":1768547363546,"version":"3.49.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI 001065"],"award-info":[{"award-number":["AI 001065"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178000","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T13:40:53Z","timestamp":1496151653000},"page":"e0178000","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prediabetes is associated with the modulation of antigen-specific Th1\/Tc1 and Th17\/Tc17 responses in latent Mycobacterium tuberculosis infection"],"prefix":"10.1371","volume":"12","author":[{"given":"Nathella Pavan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadar","family":"Moideen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrakumar","family":"Dolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kumaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-8042","authenticated-orcid":true,"given":"Subash","family":"Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"AG Tabak","year":"2013","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"DR Whiting","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11892-009-0032-7","article-title":"Pathophysiology of prediabetes","volume":"9","author":"MA Abdul-Ghani","year":"2009","journal-title":"Curr Diab Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1464-5491.2007.02068.x","article-title":"Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990\u20132000","volume":"24","author":"NG Forouhi","year":"2007","journal-title":"Diabet Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2337\/dc07-9920","article-title":"Impaired fasting glucose and impaired glucose tolerance: implications for care","volume":"30","author":"DM Nathan","year":"2007","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1371\/journal.pmed.0050152","article-title":"Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies","volume":"5","author":"CY Jeon","year":"2008","journal-title":"PLoS Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5588\/ijtld.15.0457","article-title":"Increased risk of latent tuberculous infection among persons with pre-diabetes and diabetes mellitus","volume":"20","author":"RL Hensel","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e0153590","DOI":"10.1371\/journal.pone.0153590","article-title":"Glucose Metabolism Disorder Is Associated with Pulmonary Tuberculosis in Individuals with Respiratory Symptoms from Brazil","volume":"11","author":"JL Almeida-Junior","year":"2016","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e112108","DOI":"10.1371\/journal.pone.0112108","article-title":"Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis","volume":"9","author":"NP Kumar","year":"2014","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e41367","DOI":"10.1371\/journal.pone.0041367","article-title":"Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India","volume":"7","author":"V Viswanathan","year":"2012","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"A O'Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"AM Cooper","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652407780598557","article-title":"Th2 cytokines in susceptibility to tuberculosis","volume":"7","author":"GA Rook","year":"2007","journal-title":"Curr Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.4049\/jimmunol.181.7.4955","article-title":"Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice","volume":"181","author":"EK Forbes","year":"2008","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.4049\/jimmunol.1101122","article-title":"Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load","volume":"187","author":"CL Day","year":"2011","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nm.2299","article-title":"Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease","volume":"17","author":"A Harari","year":"2011","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12274","article-title":"T cells and adaptive immunity to Mycobacterium tuberculosis in humans","volume":"264","author":"LD Jasenosky","year":"2015","journal-title":"Immunol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/eji.201545973","article-title":"Coincident diabetes mellitus modulates Th1-, Th2-, and Th17-cell responses in latent tuberculosis in an IL-10- and TGF-beta-dependent manner","volume":"46","author":"NP Kumar","year":"2016","journal-title":"Eur J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/infdis\/jiv484","article-title":"Impaired Cytokine but Enhanced Cytotoxic Marker Expression in Mycobacterium tuberculosis-Induced CD8+ T Cells in Individuals With Type 2 Diabetes and Latent Mycobacterium tuberculosis Infection","volume":"213","author":"NP Kumar","year":"2016","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/infdis\/jiu329","article-title":"Diminished systemic and antigen-specific type 1, type 17, and other proinflammatory cytokines in diabetic and prediabetic individuals with latent Mycobacterium tuberculosis infection","volume":"210","author":"NP Kumar","year":"2014","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1004099","DOI":"10.1371\/journal.ppat.1004099","article-title":"Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection","volume":"10","author":"R Gopal","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00281-015-0490-8","article-title":"CD8 T cells and Mycobacterium tuberculosis infection","volume":"37","author":"PL Lin","year":"2015","journal-title":"Semin Immunopathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/imm.12421","article-title":"Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosis","volume":"144","author":"NP Kumar","year":"2015","journal-title":"Immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T05:17:37Z","timestamp":1540271857000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178000"}},"subtitle":[],"editor":[{"given":"Francesco","family":"Dieli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178000","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}