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Forskrift om beskjempelse av lakselus i akvakulturanlegg. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/lovdata.no\/dokument\/SF\/forskrift\" xlink:type=\"simple\">http:\/\/lovdata.no\/dokument\/SF\/forskrift<\/ext-link>"},{"key":"ref8","unstructured":"Mattilsynet. Retningslinje Midlertidig reduksjon av godkjent lokalitetsbiomasse p\u00e5 grunn av vesentlige overskridelser av lusegrensen. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mattilsynet.no\/fisk_og_akvakultur\/fiskehelse\/fiske_og_skjellsykdommer\/lakselus\/kriteriene_for_redusert_produksjon_ved_langvarige_lakselusproblemer.23109\" xlink:type=\"simple\">http:\/\/www.mattilsynet.no\/fisk_og_akvakultur\/fiskehelse\/fiske_og_skjellsykdommer\/lakselus\/kriteriene_for_redusert_produksjon_ved_langvarige_lakselusproblemer.23109<\/ext-link>."},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/ps.482","article-title":"Analysis and management of resistance to chemotherapeutants in salmon lice, <italic>Lepeophtheirus salmonis<\/italic> (Copepoda: Caligidae)","volume":"58","author":"I Denholm","year":"2002","journal-title":"Pest Manag Sci"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pt.2014.12.006","article-title":"Drug resistance in sea lice: a threat to salmonid aquaculture","volume":"31","author":"SM Aaen","year":"2015","journal-title":"Trends in Parasitology"},{"key":"ref11","article-title":"The biochemical mode of action of pesticides","author":"JR Corbett","year":"1974"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00204-011-0726-x","article-title":"Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances","volume":"86","author":"DM Soderlund","year":"2012","journal-title":"Arch Toxicol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"e0124220","DOI":"10.1371\/journal.pone.0124220","article-title":"Mechanism behind Resistance against the Organophosphate Azamethiphos in Salmon Lice (<italic>Lepeophtheirus salmonis<\/italic>)","volume":"10","author":"K Kaur","year":"2015","journal-title":"PLoS ONE"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"e0149006","DOI":"10.1371\/journal.pone.0149006","article-title":"Surveillance of the Sensitivity towards Antiparasitic Bath-Treatments in the Salmon Louse (<italic>Lepeophtheirus salmonis<\/italic>)","volume":"11","author":"PA Jansen","year":"2016","journal-title":"PLoS ONE"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"e0149264","DOI":"10.1371\/journal.pone.0149264","article-title":"Phe362Tyr in AChE: A Major Factor Responsible for Azamethiphos Resistance in <italic>Lepeophtheirus salmonis<\/italic> in Norway","volume":"11","author":"K Kaur","year":"2016","journal-title":"PLoS ONE"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ps.1057","article-title":"Monooxygenase mediated pyrethroid detoxification in sea lice (<italic>Lepeophtheirus salmonis<\/italic>)","volume":"61","author":"S Sevatdal","year":"2005","journal-title":"Pest Manag Sci"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3354\/dao065129","article-title":"Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice <italic>Lepeophtheirus salmonis<\/italic> (Crustacea: Copepoda)","volume":"65","author":"A Fallang","year":"2005","journal-title":"Dis Aquat Org"},{"key":"ref18","unstructured":"Nilsen F, Espedal PG. Method for detection of pyrethroid resistance in crustaceans and oligonucleotide sequences useful in detection of pyrethroid resistance. 2013. Patent application CA2920588A1, Priority date 2013-08-06."},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.parint.2009.08.009","article-title":"Establishment and characterisation of salmon louse (<italic>Lepeophtheirus salmonis<\/italic> (Kr\u00f8yer 1837)) laboratory strains","volume":"58","author":"LA Hamre","year":"2009","journal-title":"Parasitol Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0044-8486(02)00339-3","article-title":"Determination of reduced sensitivity in sea lice (<italic>Lepeophtheirus salmonis<\/italic> Kr\u00f8yer) against the pyrethroid deltamethrin using bioassays and probit modelling","volume":"218","author":"S Sevatdal","year":"2003","journal-title":"Aquaculture"},{"key":"ref21","article-title":"Principles of Population Genetics","author":"DL Hartl","year":"2006"},{"key":"ref22","first-page":"365","article-title":"Practical Statistics for Medicinal Research","author":"DG Altman","year":"1992"},{"key":"ref23","article-title":"The Surveillance Programme for Resistance to Chemotherapeutants in Salmon Lice (<italic>Lepeophtheirus salmonis<\/italic>) in Norway 2015","author":"RN Gr\u00f8ntvedt","year":"2016"},{"key":"ref24","unstructured":"Anon. Status for norske laksebestander i 2016. Rapport fra Vitenskapelig r\u00e5d for lakseforvaltning nr 9. 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.vitenskapsradet.no\/Nyheter\/Nyhetsartikkel\/ArticleId\/4091\/Status-for-norske-laksebestander-i-2016-1\" xlink:type=\"simple\">http:\/\/www.vitenskapsradet.no\/Nyheter\/Nyhetsartikkel\/ArticleId\/4091\/Status-for-norske-laksebestander-i-2016-1<\/ext-link>"},{"issue":"1564","key":"ref25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1098\/rspb.2004.3027","article-title":"Transmission dynamics of parasitic sea lice from farm to wild salmon","volume":"272","author":"M Krkosek","year":"2005","journal-title":"Proc Biol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.chemosphere.2014.07.087","article-title":"Is acetylcholinesterase a biomarker of susceptibility in <italic>Daphnia magna<\/italic> (Crustacea, Cladocera) after deltamethrin exposure?","volume":"120","author":"H Toumi","year":"2015","journal-title":"Chemosphere"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chemosphere.2011.09.022","article-title":"Combined effects of deltamethrin, temperature and salinity on oxidative stress biomarkers and acetylcholinesterase activity in the black tiger shrimp (<italic>Penaeus monodon<\/italic>)","volume":"86","author":"HT Tu","year":"2012","journal-title":"Chemosphere"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cbi.2008.05.040","article-title":"Is acetylcholinesterase a pertinent biomarker to detect exposure of pyrethroids? 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