{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:28:39Z","timestamp":1780082919942,"version":"3.54.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81460424"],"award-info":[{"award-number":["No. 81460424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scholarship Award for Excellent Doctoral Student Grant of Yunnan Province","award":["2014."],"award-info":[{"award-number":["2014."]}]},{"name":"the Foundation of Leading Talent Program of Health and Family Planning Commission of Yunnan Province","award":["No. L-201205"],"award-info":[{"award-number":["No. L-201205"]}]},{"name":"the Foundation of Medical Discipline Leaders Program of Health and Family Planning Commission of Yunnan Province","award":["No. D-201668"],"award-info":[{"award-number":["No. D-201668"]}]},{"name":"the Foundation of the Institute of Gastroenterology, Research Institutions attached to the Health and Family Planning Commission of Yunnan Province","award":["2014NS122"],"award-info":[{"award-number":["2014NS122"]}]},{"name":"the Foundation of the Institute of Breast Surgery, Research Institutions attached to the Health and Family Planning Commission of Yunnan Province","award":["2014NS022"],"award-info":[{"award-number":["2014NS022"]}]},{"name":"the Joint Special Research Funds of Kunming Medical University","award":["2014FZ035"],"award-info":[{"award-number":["2014FZ035"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178218","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T17:41:36Z","timestamp":1496425296000},"page":"e0178218","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["TNF-\u03b1 -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China"],"prefix":"10.1371","volume":"12","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-an","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-ning","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-2392","authenticated-orcid":true,"given":"Yunlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"issue":"1","key":"ref1","first-page":"7","article-title":"Cancer statistics, 2016","volume":"66","author":"RL Siegel","year":"2016","journal-title":"CA: a cancer journal for clinicians"},{"issue":"2","key":"ref2","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"W Chen","year":"2016","journal-title":"CA: a cancer journal for clinicians"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/humu.22262","article-title":"Cancer risks for MLH1 and MSH2 mutation carriers","volume":"34","author":"JG Dowty","year":"2013","journal-title":"Human mutation"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/cncr.25440","article-title":"Cancer: more of polygenic disease and less of multiple mutations? A quantitative viewpoint","volume":"117","author":"A Bredberg","year":"2011","journal-title":"Cancer"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13304-016-0359-y","article-title":"Worldwide burden of colorectal cancer: a review","volume":"68","author":"P Favoriti","year":"2016","journal-title":"Updates Surg"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrm2858","article-title":"Genomic instability\u2014an evolving hallmark of cancer","volume":"11","author":"S Negrini","year":"2010","journal-title":"Nature reviews Molecular cell biology"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"e85187","DOI":"10.1371\/journal.pone.0085187","article-title":"Tumor necrosis factor-a polymorphisms and colorectal cancer risk: a meta-analysis","volume":"9","author":"L Min","year":"2014","journal-title":"PloS one"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.suronc.2016.05.018","article-title":"Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer","volume":"25","author":"SM Ronnekleiv-Kelly","year":"2016","journal-title":"Surgical oncology"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/138161213804581981","article-title":"Colorectal cancer microenvironment: among nutrition, gut microbiota, inflammation and epigenetics","volume":"19","author":"P Garagnani","year":"2013","journal-title":"Current pharmaceutical design"},{"issue":"14","key":"ref10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.21037\/atm.2016.05.54","article-title":"The significance of tumor-associated immune response in molecular taxonomy, prognosis and therapy of colorectal cancer patients","volume":"4","author":"A Nearchou","year":"2016","journal-title":"Annals of translational medicine"},{"issue":"26","key":"ref11","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1056\/NEJM199606273342607","article-title":"The tumor necrosis factor ligand and receptor families","volume":"334","author":"F Bazzoni","year":"1996","journal-title":"The New England journal of medicine"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","article-title":"IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages","volume":"160","author":"DV Jovanovic","year":"1998","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1470-2045(03)01196-3","article-title":"Tumour necrosis factor alpha: a potential target for the therapy of solid tumours","volume":"4","author":"PW Szlosarek","year":"2003","journal-title":"The Lancet Oncology"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13402-011-0027-7","article-title":"Tumor necrosis factor-alpha is associated with positive lymph node status in patients with recurrence of colorectal cancer-indications for anti-TNF-alpha agents in cancer treatment","volume":"34","author":"M Grimm","year":"2011","journal-title":"Cellular oncology (Dordrecht)"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1634\/theoncologist.11-4-397","article-title":"TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility","volume":"11","author":"R van Horssen","year":"2006","journal-title":"Oncologist"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","article-title":"TNF-alpha\/NF-kappaB\/Snail pathway in cancer cell migration and invasion","volume":"102","author":"Y Wu","year":"2010","journal-title":"British journal of cancer"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10555-006-9005-3","article-title":"TNF-alpha in promotion and progression of cancer","volume":"25","author":"F Balkwill","year":"2006","journal-title":"Cancer metastasis reviews"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrc1803","article-title":"Host genetics influence tumour metastasis","volume":"6","author":"K Hunter","year":"2006","journal-title":"Nature reviews Cancer"},{"issue":"Database issue","key":"ref19","doi-asserted-by":"crossref","first-page":"D1308","DOI":"10.1093\/nar\/gkr798","article-title":"SNPedia: a wiki supporting personal genome annotation, interpretation and analysis","volume":"40","author":"M Cariaso","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ibd.21681","article-title":"Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation","volume":"18","author":"M Garrity-Park","year":"2012","journal-title":"Inflammatory bowel diseases"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1053\/j.gastro.2003.08.042","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"126","author":"CF Zambon","year":"2004","journal-title":"Gastroenterology"},{"issue":"48","key":"ref22","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.3748\/wjg.v19.i48.9461","article-title":"TNF-alpha-308 polymorphism and risk of digestive system cancers: a meta-analysis","volume":"19","author":"XF Guo","year":"2013","journal-title":"World journal of gastroenterology"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1097\/MCG.0000000000000261","article-title":"Tumor Necrosis Factor-Alpha Gene Polymorphism Associated With Development of Hepatitis B Virus\u2013associated Hepatocellular Carcinoma","volume":"49","author":"Y-J Jin","year":"2015","journal-title":"Journal of Clinical Gastroenterology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"10244","DOI":"10.1038\/srep10244","article-title":"Tumour Necrosis Factor-alpha Gene Polymorphism Is Associated with Metastasis in Patients with Triple Negative Breast Cancer","volume":"5","author":"HH Li","year":"2015","journal-title":"Scientific reports"},{"issue":"45","key":"ref25","doi-asserted-by":"crossref","first-page":"e1955","DOI":"10.1097\/MD.0000000000001955","article-title":"TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy","volume":"94","author":"H Zhang","year":"2015","journal-title":"Medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11006","DOI":"10.1038\/srep11006","article-title":"Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans","volume":"5","author":"YJ Jeon","year":"2015","journal-title":"Scientific reports"},{"issue":"9927","key":"ref27","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","article-title":"Colorectal cancer","volume":"383","author":"H Brenner","year":"2014","journal-title":"Lancet"},{"key":"ref28","first-page":"3","article-title":"Genomic structure, induction, and production of TNF-alpha","volume":"56","author":"DR Spriggs","year":"1992","journal-title":"Immunology series"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.fsi.2016.06.033","article-title":"TNF-alpha is involved in apoptosis triggered by grass carp reovirus infection in vitro","volume":"55","author":"J Lu","year":"2016","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1158\/0008-5472.CAN-12-2038","article-title":"Targeting truncated retinoid X receptor-alpha by CF31 induces TNF-alpha-dependent apoptosis","volume":"73","author":"GH Wang","year":"2013","journal-title":"Cancer Res"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/labinvest.2015.34","article-title":"Galactose protects hepatocytes against TNF-alpha-induced apoptosis by promoting activation of the NF-kappaB signaling pathway in acute liver failure","volume":"95","author":"Y Liu","year":"2015","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.4049\/jimmunol.1302240","article-title":"The combination of type I IFN, TNF-alpha, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus","volume":"193","author":"DS Lim","year":"2014","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cyto.2014.10.016","article-title":"Involvement of the TNF-alpha\/TGF-beta\/IDO axis in IVIg-induced immune tolerance","volume":"71","author":"L Loubaki","year":"2015","journal-title":"Cytokine"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.humimm.2014.08.197","article-title":"TNF-alpha promoter single nucleotide polymorphisms and haplotypes associate with susceptibility of immune thrombocytopenia in Chinese adults","volume":"75","author":"N Wang","year":"2014","journal-title":"Hum Immunol"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00432-008-0393-3","article-title":"Suppression of FasL expression in tumor cells and preventing TNF-induced apoptosis was better for immune cells survival","volume":"134","author":"G Xu","year":"2008","journal-title":"Journal of cancer research and clinical oncology"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"e26718","DOI":"10.1371\/journal.pone.0026718","article-title":"TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence","volume":"6","author":"CV Hojilla","year":"2011","journal-title":"PloS one"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation","volume":"94","author":"AG Wilson","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:03:18Z","timestamp":1692828198000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178218"}},"subtitle":[],"editor":[{"given":"Aamir","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178218","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}