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Does inflammation cut to the heart of the matter?","volume":"296","author":"G Taubes","year":"2002","journal-title":"Science"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00420-016-1119-5","article-title":"Inflammatory markers and exposure to airborne particles among workers in a Swedish pulp and paper mill","volume":"89","author":"H Westberg","year":"2016","journal-title":"Int Arch Occup Environ Health"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174167","article-title":"Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice","volume":"12","author":"SS Poulsen","year":"2017","journal-title":"PLoS ONE"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0167-4838(96)00227-0","article-title":"Acute inflammation, acute phase serum amyloid A and cholesterol metabolism in the mouse","volume":"1339","author":"E Lindhorst","year":"1997","journal-title":"Biochim Biophys Acta"},{"issue":"11\u201312","key":"ref76","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.2119\/molmed.2011.00186","article-title":"Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"17","author":"Z Dong","year":"2011","journal-title":"Mol Med"},{"issue":"11","key":"ref77","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1021\/nn101781v","article-title":"Mechanical properties of monolayer graphene oxide","volume":"4","author":"JW Suk","year":"2010","journal-title":"ACS Nano"},{"issue":"49","key":"ref78","doi-asserted-by":"crossref","first-page":"18099","DOI":"10.1021\/jp075799g","article-title":"Computational Studies of the Structure, Behavior upon Heating, and Mechanical Properties of Graphite Oxide","volume":"111","author":"JT Paci","year":"2007","journal-title":"J Phys Chem C"},{"issue":"7","key":"ref79","article-title":"Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation","volume":"13","author":"L Mao","year":"2016","journal-title":"Part Fibre Toxicol"},{"issue":"5","key":"ref80","first-page":"586","article-title":"Characterization of exposure to carbon nanotubes in an industrial setting","volume":"59","author":"AS Fonseca","year":"2015","journal-title":"Ann Occup Hyg"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T07:32:00Z","timestamp":1569396720000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178355"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":80,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178355","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]}}}